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View article: Staphylococcal internalization into osteoblasts: a partially conserved mechanism across the genus
Staphylococcal internalization into osteoblasts: a partially conserved mechanism across the genus Open
Staphylococcus aureus , recognized as a major human pathogen, is associated with severe infections such as bacteremia, endocarditis, skin and soft tissue infections, and bone and joint infections. Virulence mechanisms, including biofilm fo…
View article: Responses of grapevine cells to physiological doses of ethanol, including induced resistance to heat stress
Responses of grapevine cells to physiological doses of ethanol, including induced resistance to heat stress Open
Grapevine is naturally exposed to stresses like heat, drought, and hypoxia. A recent study found very low oxygen levels inside grape berries, linked to ethanol content. Other studies have established a link between ethanol and tolerance to…
View article: Staphylococcal Internalization into Osteoblasts: A Partially Conserved Mechanism Across the Genus
Staphylococcal Internalization into Osteoblasts: A Partially Conserved Mechanism Across the Genus Open
Staphylococcus aureus, considered as a major human pathogen, is associated with severe infections such as bacteremia, endocarditis, skin and soft tissue infections, and bone and joint infections. Virulence mechanisms, such as biofilm forma…
View article: Staphylococcus aureus can use an alternative pathway to be internalized by osteoblasts in absence of β1 integrins
Staphylococcus aureus can use an alternative pathway to be internalized by osteoblasts in absence of β1 integrins Open
Staphylococcus aureus main internalization mechanism in osteoblasts relies on a tripartite interaction between bacterial fibronectin-binding proteins, extracellular matrix soluble fibronectin, and osteoblasts' β1 integrins. Caveolins, and …
View article: <i>Staphylococcus aureus</i>can use an alternative pathway to be internalized by osteoblasts in absence of β1 integrins
<i>Staphylococcus aureus</i>can use an alternative pathway to be internalized by osteoblasts in absence of β1 integrins Open
Staphylococcus aureus main internalization mechanism in osteoblasts relies on a tripartite interaction between bacterial fibronectin-binding proteins, extracellular matrix soluble fibronectin, and osteoblasts’ β1 integrins. Caveolins, and …
View article: Transcriptome Architecture of Osteoblastic Cells Infected With Staphylococcus aureus Reveals Strong Inflammatory Responses and Signatures of Metabolic and Epigenetic Dysregulation
Transcriptome Architecture of Osteoblastic Cells Infected With Staphylococcus aureus Reveals Strong Inflammatory Responses and Signatures of Metabolic and Epigenetic Dysregulation Open
Staphylococcus aureus is an opportunistic pathogen that causes a range of devastating diseases including chronic osteomyelitis, which partially relies on the internalization and persistence of S. aureus in osteoblasts. The identification o…
View article: Differential Early in vivo Dynamics and Functionality of Recruited Polymorphonuclear Neutrophils After Infection by Planktonic or Biofilm Staphylococcus aureus
Differential Early in vivo Dynamics and Functionality of Recruited Polymorphonuclear Neutrophils After Infection by Planktonic or Biofilm Staphylococcus aureus Open
Staphylococcus aureus is a human pathogen known for its capacity to shift between the planktonic and biofilm lifestyles. In vivo , the antimicrobial immune response is characterized by the recruitment of inflammatory phagocytes, namely pol…
View article: Bone and Joint Infection Involving Corynebacterium spp.: From Clinical Features to Pathophysiological Pathways
Bone and Joint Infection Involving Corynebacterium spp.: From Clinical Features to Pathophysiological Pathways Open
Introduction: Corynebacteria represent often-neglected etiological agents of post-traumatic and/or post-operative bone and joint infection (BJI). We describe here clinical characteristics and bacteriological determinants of this condition.…
View article: Investigation of a Staphylococcus argenteus Strain Involved in a Chronic Prosthetic-Joint Infection
Investigation of a Staphylococcus argenteus Strain Involved in a Chronic Prosthetic-Joint Infection Open
Staphylococcus argenteus is an emerging species responsible for infections comparable to those induced by Staphylococcus aureus. It has been involved in few chronic or persistent infections so far. In this study, we described a case of a p…
View article: Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type C
Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type C Open
Niemann–Pick disease type C (NPC) is a rare lysosomal storage disease caused by mutations in either the NPC1 or NPC2 genes. Mutations in the NPC1 gene lead to the majority of clinical cases (95%); however, the function of NPC1 remains unkn…
View article: Identification and Characterization of Staphylococcus delphini Internalization Pathway in Nonprofessional Phagocytic Cells
Identification and Characterization of Staphylococcus delphini Internalization Pathway in Nonprofessional Phagocytic Cells Open
The intracellular lifestyle of bacteria is widely acknowledged to be an important mechanism in chronic and recurring infection. Among the Staphylococcus genus, only Staphylococcus aureus and Staphylococcus pseudintermedius have been clearl…
View article: Staphylococcus aureus Small Colony Variants (SCVs): News From a Chronic Prosthetic Joint Infection
Staphylococcus aureus Small Colony Variants (SCVs): News From a Chronic Prosthetic Joint Infection Open
Small colony variants (SCV) of Staphylococcus aureus have been reported as implicated in chronic infections. Here, we investigated the genomic and transcriptomic changes involved in the evolution from a wild-type to a SCV from in a patient…
View article: Interaction Between Staphylococcal Biofilm and Bone: How Does the Presence of Biofilm Promote Prosthesis Loosening?
Interaction Between Staphylococcal Biofilm and Bone: How Does the Presence of Biofilm Promote Prosthesis Loosening? Open
With the aging of population, the number of indications for total joint replacement is continuously increasing. However, prosthesis loosening can happen and is related to two major mechanisms: (1) aseptic loosening due to prosthesis microm…
View article: Evaluation of the ability of linezolid and tedizolid to eradicate intraosteoblastic and biofilm-embedded <i>Staphylococcus aureus</i> in the bone and joint infection setting
Evaluation of the ability of linezolid and tedizolid to eradicate intraosteoblastic and biofilm-embedded <i>Staphylococcus aureus</i> in the bone and joint infection setting Open
Linezolid and tedizolid alone are not optimal candidates to target bacterial phenotypes associated with chronic forms of BJI. Despite weak intracellular activity, they both reduce infection-related cytotoxicity, suggesting a role in modula…
View article: Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation
Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation Open
Background: Autosomal dominant optic atrophy (ADOA) is usually caused by mutations in the essential gene, OPA1. This encodes a ubiquitous protein involved in mitochondrial dynamics, hence tissue specificity is not understood. Dysregulated …
View article: Understanding the Virulence of Staphylococcus pseudintermedius: A Major Role of Pore-Forming Toxins
Understanding the Virulence of Staphylococcus pseudintermedius: A Major Role of Pore-Forming Toxins Open
Staphylococcus pseudintermedius is responsible for severe and necrotizing infections in humans and dogs. Contrary to S. aureus, the pathophysiological mechanisms involved in this virulence are incompletely understood. We previously showed …
View article: Staphylococcal Adhesion and Host Cell Invasion: Fibronectin-Binding and Other Mechanisms
Staphylococcal Adhesion and Host Cell Invasion: Fibronectin-Binding and Other Mechanisms Open
Opportunistic bacteria from the genus Staphylococcus can cause life-threatening infections such as pneumonia, endocarditis, bone and joint infections, and sepsis. This pathogenicity is closely related to their capacity to bind directly to …
View article: Acute nutritional stress during pregnancy affects placental efficiency, fetal growth and adult glucose homeostasis
Acute nutritional stress during pregnancy affects placental efficiency, fetal growth and adult glucose homeostasis Open
Exposure to maternal malnutrition impairs postnatal health. Acute nutritional stress is less clearly implicated in intrauterine programming. We studied the effects of stressing pregnant mothers on perinatal growth and adult glucose homeost…
View article: Correction: Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse?
Correction: Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse? Open
[This corrects the article DOI: 10.1371/journal.pone.0130631.].
View article: Dysregulated mitophagy and mitochondrial organization in optic atrophy due to <i>OPA1</i> mutations
Dysregulated mitophagy and mitochondrial organization in optic atrophy due to <i>OPA1</i> mutations Open
We demonstrated increased mitophagy and excessive mitochondrial fragmentation in primary human cultures associated with DOA plus due to biallelic OPA1 mutations. We previously found that increased mitophagy (mitochondrial recycling) was as…
View article: Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children
Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children Open
One in 400 people has a maternally inherited mutation in mtDNA potentially causing incurable disease. In so-called heteroplasmic disease, mutant and normal mtDNA co-exist in the cells of carrier women. Disease severity depends on the propo…
View article: The m.13051G>A mitochondrial DNA mutation results in variable neurology and activated mitophagy
The m.13051G>A mitochondrial DNA mutation results in variable neurology and activated mitophagy Open
Maternally-inherited mitochondrial DNA (mtDNA) mutations cause symptoms of Leber’s hereditary optic neuropathy (LHON) in~ 1 in 30,000 individuals. Most of the affected individuals lack respiratory chain defects and there is no proven proph…
View article: Mitochondrial content is central to nuclear gene expression: Profound implications for human health
Mitochondrial content is central to nuclear gene expression: Profound implications for human health Open
We review a recent paper in Genome Research by Guantes et al. showing that nuclear gene expression is influenced by the bioenergetic status of the mitochondria. The amount of energy that mitochondria make available for gene expression vari…
View article: Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse?
Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse? Open
These findings reinforce the pathophysiological links between maternal diet and conceptus mitochondria, potentially contributing to metabolic programming. The quiet embryo hypothesis proposes that pre-implantation embryo survival is best s…