Alan E. Gross
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View article: A Comparison of a Solid Organ Transplant Population‐Specific Antibiogram With the Hospital‐Wide Antibiogram
A Comparison of a Solid Organ Transplant Population‐Specific Antibiogram With the Hospital‐Wide Antibiogram Open
Background Solid organ transplant (SOT) recipients are vulnerable to infections with multidrug‐resistant organisms, and they often do not receive adequate empiric antimicrobials for serious Gram‐negative infections. Knowledge of difference…
View article: Pharmacodynamic insights to support pneumonia treatment in a patient co-infected with two carbapenem-resistant bacteria
Pharmacodynamic insights to support pneumonia treatment in a patient co-infected with two carbapenem-resistant bacteria Open
Identifying optimal antibiotic therapy for patients infected with extensively resistant bacteria is challenging, particularly when there are multiple organisms at the infection site. Personalized time-kill assays (TKAs) can be used to test…
View article: The impact of pharmacist-led education and prospective audit and feedback on antibiotic dose optimization within medical intensive care units in Thailand: a retrospective study
The impact of pharmacist-led education and prospective audit and feedback on antibiotic dose optimization within medical intensive care units in Thailand: a retrospective study Open
Pharmacist-led education and prospective audit and feedback on antibiotic dose optimization can improve appropriate antibiotic dosing and therapeutic drug monitoring with a high acceptance rate. We suggest implementing this strategy in oth…
View article: P-1656. Different Drugs for Different Bugs? A Comparison of a Solid Organ Transplant Population-specific Antibiogram with the Hospital-wide Antibiogram
P-1656. Different Drugs for Different Bugs? A Comparison of a Solid Organ Transplant Population-specific Antibiogram with the Hospital-wide Antibiogram Open
Background Solid organ transplant (SOT) recipients are vulnerable to infections with multi-drug resistant organisms. Studies have shown that SOT patients often do not receive adequate empiric antimicrobials for serious Gram-negative infect…
View article: 311. Defining the magnitude of desirability of outcome ranking (DOOR) differences in effectiveness of Ceftazidime-Avibactam (CZA) versus Ceftolozane-Tazobactam (C/T) for multidrug-resistant (MDR) <i>Pseudomonas aeruginosa</i> infections in the United States (CACTUS)
311. Defining the magnitude of desirability of outcome ranking (DOOR) differences in effectiveness of Ceftazidime-Avibactam (CZA) versus Ceftolozane-Tazobactam (C/T) for multidrug-resistant (MDR) <i>Pseudomonas aeruginosa</i> infections in the United States (CACTUS) Open
Background CACTUS is a retrospective, matched, multicenter study comparing the efficacy of C/T and CZA for the treatment of bacteremia or pneumonia due to MDR P. aeruginosa. We previously demonstrated that treatment with C/T resulted in hi…
View article: 312. Impact of Patient Subgroups on the Efficacy of Ceftazidime-Avibactam (CZA) versus Ceftolozane-Tazobactam (C/T) for Multidrug-resistant (MDR) <i>Pseudomonas aeruginosa</i> infections in the United States (CACTUS)
312. Impact of Patient Subgroups on the Efficacy of Ceftazidime-Avibactam (CZA) versus Ceftolozane-Tazobactam (C/T) for Multidrug-resistant (MDR) <i>Pseudomonas aeruginosa</i> infections in the United States (CACTUS) Open
Background CACTUS is a retrospective, matched, multicenter study comparing the efficacy of C/T and CZA for treatment of bacteremia or pneumonia due to MDR P. aeruginosa. We found that treatment with C/T resulted in higher rates of clinical…
View article: Lessons learned from a diagnostic stewardship intervention in response to a blood culture bottle supply shock
Lessons learned from a diagnostic stewardship intervention in response to a blood culture bottle supply shock Open
Faced with a national blood culture bottle shortage, our institution formed a multidisciplinary stewardship team and implemented policy changes. This reduced orders by 60%, potentially saving $145,000 monthly, while maintaining stable in-h…
View article: A Multicenter Retrospective Study Evaluating Intravenous to Oral Antibiotic Stepdown for Uncomplicated Streptococcal Bacteremia
A Multicenter Retrospective Study Evaluating Intravenous to Oral Antibiotic Stepdown for Uncomplicated Streptococcal Bacteremia Open
Background The purpose of this study was to compare the efficacy and safety of intravenous (IV) versus oral (PO) stepdown therapy for uncomplicated streptococcal bacteremia. Methods This multicenter, retrospective study included adult pati…
View article: Barriers and facilitators to guideline concordant dental antibiotic prescribing in the United States: A qualitative study of the National Dental <scp>PBRN</scp>
Barriers and facilitators to guideline concordant dental antibiotic prescribing in the United States: A qualitative study of the National Dental <span>PBRN</span> Open
Objectives While factors contributing to dental antibiotic overprescribing have previously been described, previous work has lacked any theoretical behavior change framework that could guide future intervention development. The purpose of …
View article: Empirical antimicrobial prescribing for pyelonephritis in patients discharged from 15 US Emergency Departments: an opportunity for improvement
Empirical antimicrobial prescribing for pyelonephritis in patients discharged from 15 US Emergency Departments: an opportunity for improvement Open
Background Urinary tract infections (UTIs) are commonly treated in the emergency department (ED), and unfortunately, resistance to first-line agents is increasing. Objectives To characterize treatment of pyelonephritis in a nationally repr…
View article: Changes in antibiotic prescribing by dentists in the United States, 2012–2019
Changes in antibiotic prescribing by dentists in the United States, 2012–2019 Open
Objectives: Dentists prescribe 10% of all outpatient antibiotics in the United States and are the top specialty prescriber. Data on current antibiotic prescribing trends are scarce. Therefore, we evaluated trends in antibiotic prescribing …
View article: Decreased hospital readmissions after programmatic strengthening of an outpatient parenteral antimicrobial therapy (OPAT) program
Decreased hospital readmissions after programmatic strengthening of an outpatient parenteral antimicrobial therapy (OPAT) program Open
Objective: To determine whether a structured OPAT program supervised by an infectious disease physician and led by an OPAT nurse decreased hospital readmission rates and OPAT-related complications and whether it affected clinical cure. We …
View article: Evaluation of Outpatient Antibiotic Prescribing for Urinary Tract Infection in Pediatric Patients Ages 2 Months to 18 Years
Evaluation of Outpatient Antibiotic Prescribing for Urinary Tract Infection in Pediatric Patients Ages 2 Months to 18 Years Open
OBJECTIVE To characterize the diagnosis and management of urinary tract infection (UTI) in pediatric patients at the University of Illinois Hospital and Health Sciences System (UIH), with an emphasis on antibiotic prescribing; in addition,…
View article: The perfect storm: respiratory viral surges and anti-infective shortages
The perfect storm: respiratory viral surges and anti-infective shortages Open
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View article: Evaluation of the accuracy of a mandatory indication field for outpatient antibiotic prescriptions
Evaluation of the accuracy of a mandatory indication field for outpatient antibiotic prescriptions Open
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View article: Cost evaluation of a nurse coordinated outpatient parenteral antimicrobial therapy (OPAT) program
Cost evaluation of a nurse coordinated outpatient parenteral antimicrobial therapy (OPAT) program Open
A structured, nurse-driven outpatient parenteral antimicrobial therapy (OPAT) program within an academic healthcare system was associated with reduced odds of 60-day unplanned OPAT readmissions and costs after hospital discharge. These fin…
View article: SHEA statement on antibiotic stewardship in hospitals during public health emergencies
SHEA statement on antibiotic stewardship in hospitals during public health emergencies Open
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View article: Reporting behaviors and perceptions toward the National Healthcare Safety Network antimicrobial use (AU) and antimicrobial resistance (AR) modules
Reporting behaviors and perceptions toward the National Healthcare Safety Network antimicrobial use (AU) and antimicrobial resistance (AR) modules Open
Objectives: To identify characteristics of US health systems and end users that report antimicrobial use and resistance (AUR) data, to determine how NHSN AUR data are used by hospitals and health systems and end users, and to identify barr…
View article: High prevalence of fluoroquinolone‐resistant <scp>UTI</scp> among <scp>US</scp> emergency department patients diagnosed with urinary tract infection, 2018–2020
High prevalence of fluoroquinolone‐resistant <span>UTI</span> among <span>US</span> emergency department patients diagnosed with urinary tract infection, 2018–2020 Open
Background Uropathogen resistance, fluoroquinolone‐resistance (FQR), and extended spectrum beta‐lactamase (ESBL), has been observed to be emerging worldwide with prevalences above recommended thresholds for routine empirical treatment. The…
View article: Perioperative antimicrobial prophylaxis in patients receiving antibiotic therapy
Perioperative antimicrobial prophylaxis in patients receiving antibiotic therapy Open
Objective Antimicrobial prophylaxis is administered perioperatively to prevent surgical site infections. However, in patients who have already received antibiotics for the treatment of active infections prior to surgery, the risks and bene…
View article: Strength of Recommendation and Quality of Evidence for Recommendations in Current Infectious Diseases Society of America Guidelines
Strength of Recommendation and Quality of Evidence for Recommendations in Current Infectious Diseases Society of America Guidelines Open
Background Grading of Recommendations Assessment, Development, and Evaluation (GRADE) is a systematic approach to grading strength of recommendation (SOR) and quality of evidence (QOE) for guideline recommendations. We aimed to assess the …
View article: Implementation and outcomes of a severe acute respiratory coronavirus virus 2 (SARS-CoV-2) monoclonal antibody treatment program at an academic medical center serving a high-risk patient population
Implementation and outcomes of a severe acute respiratory coronavirus virus 2 (SARS-CoV-2) monoclonal antibody treatment program at an academic medical center serving a high-risk patient population Open
Implementation and outcomes of a severe acute respiratory coronavirus virus 2 (SARS-CoV-2) monoclonal antibody treatment program at an academic medical center serving a high-risk patient population - Volume 1 Issue 1
View article: ICE volume 42 issue 1 Cover and Front matter
ICE volume 42 issue 1 Cover and Front matter Open
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View article: Serious antibiotic-related adverse effects following unnecessary dental prophylaxis in the United States
Serious antibiotic-related adverse effects following unnecessary dental prophylaxis in the United States Open
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View article: 600. Decreased Hospital Readmission After Programmatic Strengthening of an Outpatient Parenteral Antimicrobial Therapy (OPAT) Program
600. Decreased Hospital Readmission After Programmatic Strengthening of an Outpatient Parenteral Antimicrobial Therapy (OPAT) Program Open
Background Although it is recommended that an OPAT program should be managed by a formal OPAT team that supports the treating physician, many OPAT programs face challenges in obtaining necessary program staff (i.e nurses or pharmacists) du…
View article: 218. Changes in Dental Antibiotic Prescribing in the United States, 2012–2017
218. Changes in Dental Antibiotic Prescribing in the United States, 2012–2017 Open
Background Data suggest dental antibiotic prescribing is increasing with relatively less documented about prescribing trends in adults and children. Therefore, the aim was to evaluate trends in antibiotic prescribing by US dentists from 20…
View article: 621. Reporting Behaviors and Perceptions Towards the National Healthcare Safety Network Antimicrobial Use (AU) and Antimicrobial Resistance (AR) Options
621. Reporting Behaviors and Perceptions Towards the National Healthcare Safety Network Antimicrobial Use (AU) and Antimicrobial Resistance (AR) Options Open
Background Antibiotic use (AU) and antibiotic resistance (AR; AUR) reporting to National Healthcare Safety Network (NHSN) is suboptimal by US hospitals. The Society of Infectious Diseases Pharmacists (SIDP) and the Society for Healthcare E…