Alan F. Wright
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View article: List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta Open
Cancer Research UK Rosetta Grand Challenge consortium list of members
View article: List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta Open
Cancer Research UK Rosetta Grand Challenge consortium list of members
View article: Data from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
Data from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta Open
Summary:Understanding tumor heterogeneity is a major challenge that was recognized as one of the first Cancer Grand Challenges, with a call to provide solutions to visualize tumor heterogeneity. The Rosetta team took on this challenge, exp…
View article: Treatment Strategy With Gene Editing for Late-Onset Retinal Degeneration Caused by a Founder Variant in <i>C1QTNF5</i>
Treatment Strategy With Gene Editing for Late-Onset Retinal Degeneration Caused by a Founder Variant in <i>C1QTNF5</i> Open
Retinal regions providing an ideal treatment window exist across all severity stages of L-ORD.
View article: In vivo measurement of mitochondrial ROS production in mouse models of photoreceptor degeneration
In vivo measurement of mitochondrial ROS production in mouse models of photoreceptor degeneration Open
Retinitis pigmentosa (RP) is a disease characterised by photoreceptor cell death. It can be initiated by mutations in a number of different genes, primarily affecting rods, which will die first, resulting in loss of night vision. The secon…
View article: Assessment of the sensitivity of <sup>2</sup>H MR spectroscopy measurements of [2,3‐<sup>2</sup>H<sub>2</sub>]fumarate metabolism for detecting tumor cell death
Assessment of the sensitivity of <sup>2</sup>H MR spectroscopy measurements of [2,3‐<sup>2</sup>H<sub>2</sub>]fumarate metabolism for detecting tumor cell death Open
Imaging the metabolism of [2,3‐ 2 H 2 ]fumarate to produce malate can be used to detect tumor cell death post‐treatment. Here, we assess the sensitivity of the technique for detecting cell death by lowering the concentration of injected [2…
View article: Supplementary Figure S1 from Carbonic Anhydrase Activity Monitored <i>In Vivo</i> by Hyperpolarized <sup>13</sup>C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Supplementary Figure S1 from Carbonic Anhydrase Activity Monitored <i>In Vivo</i> by Hyperpolarized <sup>13</sup>C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors Open
Supplementary Figure S1. Representative 31P-MRS spectra of EV5 and CA9/1 tumors.
View article: Data from Carbonic Anhydrase Activity Monitored <i>In Vivo</i> by Hyperpolarized <sup>13</sup>C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Data from Carbonic Anhydrase Activity Monitored <i>In Vivo</i> by Hyperpolarized <sup>13</sup>C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors Open
Carbonic anhydrase buffers tissue pH by catalyzing the rapid interconversion of carbon dioxide (CO2) and bicarbonate (HCO3−). We assessed the functional activity of CAIX in two colorectal tumor models, expressing different levels of the en…
View article: Supplementary Figure Legend from Carbonic Anhydrase Activity Monitored <i>In Vivo</i> by Hyperpolarized <sup>13</sup>C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Supplementary Figure Legend from Carbonic Anhydrase Activity Monitored <i>In Vivo</i> by Hyperpolarized <sup>13</sup>C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors Open
Supplementary Figure Legend. Legend for Supplementary Figure S1.
View article: Supplementary Figure S1 from Carbonic Anhydrase Activity Monitored <i>In Vivo</i> by Hyperpolarized <sup>13</sup>C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Supplementary Figure S1 from Carbonic Anhydrase Activity Monitored <i>In Vivo</i> by Hyperpolarized <sup>13</sup>C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors Open
Supplementary Figure S1. Representative 31P-MRS spectra of EV5 and CA9/1 tumors.
View article: Supplementary Figure Legend from Carbonic Anhydrase Activity Monitored <i>In Vivo</i> by Hyperpolarized <sup>13</sup>C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Supplementary Figure Legend from Carbonic Anhydrase Activity Monitored <i>In Vivo</i> by Hyperpolarized <sup>13</sup>C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors Open
Supplementary Figure Legend. Legend for Supplementary Figure S1.
View article: Data from Carbonic Anhydrase Activity Monitored <i>In Vivo</i> by Hyperpolarized <sup>13</sup>C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Data from Carbonic Anhydrase Activity Monitored <i>In Vivo</i> by Hyperpolarized <sup>13</sup>C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors Open
Carbonic anhydrase buffers tissue pH by catalyzing the rapid interconversion of carbon dioxide (CO2) and bicarbonate (HCO3−). We assessed the functional activity of CAIX in two colorectal tumor models, expressing different levels of the en…
View article: Coastal wetland restoration based on hydrogeomorphic space units &#8212;&#8212;Taking the coastal wetland of Yancheng, Jiangsu as an example
Coastal wetland restoration based on hydrogeomorphic space units ——Taking the coastal wetland of Yancheng, Jiangsu as an example Open
<p>As an important indicator of wetland hydrology, hydrogeomorphic conditions clearly indicate the coupling relationships between hydrology, landscape, and habitat. Aiming at problems of small-scale recovery and lack of systematic gu…
View article: Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits
Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits Open
To efficiently transform genetic associations into drug targets requires evidence that a particular gene, and its encoded protein, contribute causally to a disease. To achieve this, we employ a three-step proteome-by-phenome Mendelian Rand…
View article: Protein genome-wide associations from the paper 'Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits'.
Protein genome-wide associations from the paper 'Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits'. Open
Data in support of the manuscript "Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits".
View article: Lipidomics, Atrial Conduction, and Body Mass Index
Lipidomics, Atrial Conduction, and Body Mass Index Open
Background: Lipids are increasingly involved in cardiovascular risk prediction as potential proarrhythmic influencers. However, knowledge is limited about the specific mechanisms connecting lipid alterations with atrial conduction. Methods…
View article: GLP-1 Receptor Agonists for Type 2 Diabetes and Their Role in Primary Care: An Australian Perspective
GLP-1 Receptor Agonists for Type 2 Diabetes and Their Role in Primary Care: An Australian Perspective Open
The ever-increasing number of drugs available to treat type 2 diabetes and the complexity of patients with this condition present a constant challenge when it comes to identifying the most appropriate treatment approach. The more recent gl…
View article: Proteome-by-phenome Mendelian Randomisation detects 38 proteins with causal roles in human diseases and traits
Proteome-by-phenome Mendelian Randomisation detects 38 proteins with causal roles in human diseases and traits Open
Target identification remains a crucial challenge in drug development. To enable unbiased detection of proteins and pathways that have a causal role in disease pathogenesis or progression, we propose proteome-by-phenome Mendelian Randomisa…
View article: Mortality and Cancer Incidence in Carriers of Balanced Robertsonian Translocations: A National Cohort Study
Mortality and Cancer Incidence in Carriers of Balanced Robertsonian Translocations: A National Cohort Study Open
A balanced robertsonian translocation (rob) results from fusion of 2 acrocentric chromosomes. Carriers are phenotypically normal and are often diagnosed because of recurrent miscarriages, infertility, or aneuploid offspring. Mortality and …
View article: Mortality and cancer incidence in carriers of constitutional t(11;22)(q23;q11) translocations: A prospective study
Mortality and cancer incidence in carriers of constitutional t(11;22)(q23;q11) translocations: A prospective study Open
The constitutional t(11;22)(q23;q11) translocation is the only recurrent non‐Robertsonian translocation known in humans. Carriers are phenotypically normal and are usually referred for cytogenetic testing because of multiple miscarriages, …
View article: Cone Vision Changes in the Enhanced S-Cone Syndrome Caused by<i>NR2E3</i>Gene Mutations
Cone Vision Changes in the Enhanced S-Cone Syndrome Caused by<i>NR2E3</i>Gene Mutations Open
Murine proof-of-concept studies suggest that clinical trials of patients with NR2E3 mutations may be forthcoming. Patterns of S-cone hyperfunction across the field would serve as a means to categorize patients as entry criteria or cohort s…
View article: Unilateral retinitis pigmentosa occurring in an individual with a mutation in the <i>CLRN1</i> gene
Unilateral retinitis pigmentosa occurring in an individual with a mutation in the <i>CLRN1</i> gene Open
This case report depicts the clinical course of a female patient with unilateral retinitis pigmentosa, who first presented at the age of 12 years. Fundus photography at the time revealed unilateral pigmentary retinopathy, which was associa…