Alan Fappi
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View article: Pollution, climate extremes, and psychosocial stress: emerging environmental risks for cardiovascular disease: a review
Pollution, climate extremes, and psychosocial stress: emerging environmental risks for cardiovascular disease: a review Open
Environmental stressors like pollution, extreme temperatures, and psychosocial stress are increasingly recognized as significant but underappreciated contributors to cardiovascular disease (CVD), including cardiomyopathy. These exposures d…
View article: Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People With Metabolically Abnormal Obesity
Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People With Metabolically Abnormal Obesity Open
Observational studies have shown correlations between intramyocellular lipid (IMCL) content and muscle strength and contractile function in people with metabolically abnormal obesity. However, a clear physiologic mechanism for this associa…
View article: Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People with Metabolically Abnormal Obesity
Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People with Metabolically Abnormal Obesity Open
Observational studies show correlations between intramyocellular lipid (IMCL) content and muscle strength and contractile function in people with “metabolically abnormal” obesity. However, a clear physiologic mechanism for this association…
View article: Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People with Metabolically Abnormal Obesity
Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People with Metabolically Abnormal Obesity Open
Observational studies show correlations between intramyocellular lipid (IMCL) content and muscle strength and contractile function in people with “metabolically abnormal” obesity. However, a clear physiologic mechanism for this association…
View article: Dietary protein intake and obesity-associated cardiometabolic function
Dietary protein intake and obesity-associated cardiometabolic function Open
Purpose of review High-protein intake is commonly recommended to help people manage body weight. However, high-protein intake could have adverse health consequences. Here we review the latest findings concerning the effect of high-protein …
View article: Different physiological mechanisms underlie an adverse cardiovascular disease risk profile in men and women
Different physiological mechanisms underlie an adverse cardiovascular disease risk profile in men and women Open
CVD affect about one-third of the population and are the leading cause of mortality. The prevalence of CVD is closely linked to the prevalence of obesity because obesity is commonly associated with metabolic abnormalities that are importan…
View article: Skeletal Muscle Response to Deflazacort, Dexamethasone and Methylprednisolone
Skeletal Muscle Response to Deflazacort, Dexamethasone and Methylprednisolone Open
Glucocorticoids represent some of the most prescribed drugs that are widely used in the treatment of neuromuscular diseases, but their usage leads to side effects such as muscle atrophy. However, different synthetic glucocorticoids can lea…
View article: Omega-3 multiple effects increasing glucocorticoid-induced muscle atrophy: autophagic, AMPK and UPS mechanisms
Omega-3 multiple effects increasing glucocorticoid-induced muscle atrophy: autophagic, AMPK and UPS mechanisms Open
Muscle atrophy occurs in many conditions, including use of glucocorticoids. N-3 (omega-3) is widely consumed due its healthy properties; however, concomitant use with glucocorticoids can increase its side effects. We evaluated the influenc…