Alan Fenwick
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View article: The associations between Schistosoma mansoni infection, pre-treatment symptoms, praziquantel side effects, and treatment efficacy in Ugandan school-aged children
The associations between Schistosoma mansoni infection, pre-treatment symptoms, praziquantel side effects, and treatment efficacy in Ugandan school-aged children Open
Background Over 240 million people have schistosomiasis. Mass drug administration (MDA) with the anthelmintic praziquantel is the cornerstone of control. Treatment side effects are commonly observed and may be associated with dying worms. …
View article: The associations between<i>Schistosoma mansoni</i>infection, pre-treatment symptoms, praziquantel side effects, and treatment efficacy in Ugandan school-aged children
The associations between<i>Schistosoma mansoni</i>infection, pre-treatment symptoms, praziquantel side effects, and treatment efficacy in Ugandan school-aged children Open
Background Over 240 million people have schistosomiasis. Mass drug administration (MDA) with the anthelmintic praziquantel is the cornerstone of control. Treatment side effects are commonly observed and potentially associated with worms dy…
View article: A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs–monitoring of therapeutic drug efficacy as a case study
A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs–monitoring of therapeutic drug efficacy as a case study Open
Background Soil-transmitted helminth (STH) control programs currently lack evidence-based recommendations for cost-efficient survey designs for monitoring and evaluation. Here, we present a framework to provide evidence-based recommendatio…
View article: A general framework to support cost-efficient fecal egg count method and study design choices for large-scale STH deworming programs – monitoring of therapeutic drug efficacy as a case study
A general framework to support cost-efficient fecal egg count method and study design choices for large-scale STH deworming programs – monitoring of therapeutic drug efficacy as a case study Open
Background Soil-transmitted helminth (STH) control programs currently lack evidence-based recommendations for cost-efficient survey designs for monitoring and evaluation. Here, we present a framework to provide evidence-based recommendatio…
View article: Impact of a 5-Year Mass Drug Administration Programme for Soil-Transmitted Helminthiases on the Spatial Distribution of Childhood Anaemia in Burundi from 2007 to 2011
Impact of a 5-Year Mass Drug Administration Programme for Soil-Transmitted Helminthiases on the Spatial Distribution of Childhood Anaemia in Burundi from 2007 to 2011 Open
Background: Childhood anaemia affects 1.8 billion people globally. Little is known about the long-term impact of mass drug administration (MDA) for the control of soil-transmitted helminthiases (STH) on the spatiotemporal variation of anae…
View article: A systematic literature review of schistosomiasis in urban and peri-urban settings
A systematic literature review of schistosomiasis in urban and peri-urban settings Open
Background Schistosomiasis is a parasitic disease caused by trematode worms of the genus Schistosoma and belongs to the neglected tropical diseases. The disease has been reported in 78 countries, with around 290.8 million people in need of…
View article: The new COVID-19 poor and the neglected tropical diseases resurgence
The new COVID-19 poor and the neglected tropical diseases resurgence Open
More than 100 million people are facing a return to extreme poverty because of coronavirus disease 2019 (COVID-19), while new estimates suggest that threenations—India, Nigeria, and the Democratic Republic of the Congo—may suffer the great…
View article: The history of the neglected tropical disease movement
The history of the neglected tropical disease movement Open
The history of the neglected tropical disease movement is seen through the lens of authors who worked during the last 4 decades in different roles and in different settings, from Western-based laboratories to clinical roles in endemic coun…
View article: Correction: Female genital schistosomiasis and HIV/AIDS: Reversing the neglect of girls and women
Correction: Female genital schistosomiasis and HIV/AIDS: Reversing the neglect of girls and women Open
[This corrects the article DOI: 10.1371/journal.pntd.0007025.].
View article: National mapping of soil-transmitted helminth and schistosome infections in Ethiopia
National mapping of soil-transmitted helminth and schistosome infections in Ethiopia Open
Background: An accurate understanding of the geographical distributions of both soil-transmitted helminths (STHs; Ascaris lumbricoides , Trichuris trichiura , and the hookworms Necator americanus and Ancylostoma duodenale ) and schistosome…
View article: National mapping of soil-transmitted helminth and schistosome infections in Ethiopia
National mapping of soil-transmitted helminth and schistosome infections in Ethiopia Open
Background: An accurate understanding of the geographical distributions of both soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris trichiura, and the hookworms (Necator americanus and Ancylostoma duodenale) and schistosomes …
View article: Evaluating the Impact of Biannual School-Based and Community-Wide Treatment on Urogenital Schistosomiasis in Niger
Evaluating the Impact of Biannual School-Based and Community-Wide Treatment on Urogenital Schistosomiasis in Niger Open
Background The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) coordinated a five-year study implemented in several countries, including Niger, to provide an evidence-base for programmatic decisions regarding cos…
View article: National mapping of soil-transmitted helminth and schistosome infections in Ethiopia
National mapping of soil-transmitted helminth and schistosome infections in Ethiopia Open
Background : An accurate understanding of the geographical distributions of both soil-transmitted helminths (STHs; Ascaris lumbricoides , Trichuris trichiura , and the hookworms ( Necator americanus and Ancylostoma duodenale ) and schistos…
View article: Impact of Different Mass Drug Administration Strategies for Gaining and Sustaining Control of Schistosoma mansoni and Schistosoma haematobium Infection in Africa
Impact of Different Mass Drug Administration Strategies for Gaining and Sustaining Control of Schistosoma mansoni and Schistosoma haematobium Infection in Africa Open
This report summarizes the design and outcomes of randomized controlled operational research trials performed by the Bill & Melinda Gates Foundation-funded Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) from 200…
View article: Parasite associations predict infection risk: incorporating co-infections in predictive models for neglected tropical diseases
Parasite associations predict infection risk: incorporating co-infections in predictive models for neglected tropical diseases Open
Background Schistosomiasis and infection by soil-transmitted helminths are some of the world’s most prevalent neglected tropical diseases. Infection by more than one parasite (co-infection) is common and can contribute to clinical morbidit…
View article: National mapping of soil-transmitted helminth and schistosome infections in Ethiopia
National mapping of soil-transmitted helminth and schistosome infections in Ethiopia Open
Background : The geographical distributions of both soil-transmitted helminths (STHs; Ascarislumbricoides , Trichuristrichiura , and the hookworms ( Necatoramericanus and Ancylostomaduodenale ) and schistosomes (SCH; Schistosomamansoni and…
View article: Additional file 1 of Parasite associations predict infection risk: incorporating co-infections in predictive models for neglected tropical diseases
Additional file 1 of Parasite associations predict infection risk: incorporating co-infections in predictive models for neglected tropical diseases Open
Additional file 1. R Code and raw infection/covariate data needed to replicate CRF and GBM analyses.
View article: Mapping Schistosoma mansoni endemicity in Rwanda: a critical assessment of geographical disparities arising from circulating cathodic antigen versus Kato-Katz diagnostics
Mapping Schistosoma mansoni endemicity in Rwanda: a critical assessment of geographical disparities arising from circulating cathodic antigen versus Kato-Katz diagnostics Open
Our findings show that people in Rwanda's Northern, Western and capital regions are at high risk of S. mansoni infection. However, variation in identification of environmental risk factors and delineation of at-risk regions using different…
View article: The association between child Schistosoma spp. infections and morbidity in an irrigated rice region in Mali: A localized study
The association between child Schistosoma spp. infections and morbidity in an irrigated rice region in Mali: A localized study Open
Our research contributes an important micro-geographical assessment of the heavy burden of schistosomiasis and associated morbidity in children who live in the rice irrigation regions. Our literature review found that there has been very l…
View article: Mapping Soil-Transmitted Helminth Parasite Infection in Rwanda: Estimating Endemicity and Identifying At-Risk Populations
Mapping Soil-Transmitted Helminth Parasite Infection in Rwanda: Estimating Endemicity and Identifying At-Risk Populations Open
Soil-transmitted helminth (STH) infections are globally distributed intestinal parasite infections caused by Ascaris lumbricoides, Trichuris trichiura, and hookworms (Ancylostoma duodenale and Necator americanus). STH infection constitutes…
View article: Collateral Benefits of Preventive Chemotherapy — Expanding the War on Neglected Tropical Diseases
Collateral Benefits of Preventive Chemotherapy — Expanding the War on Neglected Tropical Diseases Open
Collateral Benefits of Preventive Chemotherapy Collateral effects of mass drug administration have reduced disease burdens on a scale exceeding the intended impact on seven neglected tropical disea...
View article: Female genital schistosomiasis and HIV/AIDS: Reversing the neglect of girls and women
Female genital schistosomiasis and HIV/AIDS: Reversing the neglect of girls and women Open
Since the 2000s, we have known that female genital schistosomiasis (FGS) is likely the most neglected gynecologic condition and HIV/AIDS cofactor across sub-Saharan Africa.To date, the global health and HIV/AIDS communities have not used t…
View article: Ghana: Accelerating neglected tropical disease control in a setting of economic development
Ghana: Accelerating neglected tropical disease control in a setting of economic development Open
Ghana is exhibiting impressive economic gains that may compare with the growth rates expected in India or China. With economic development, there is an expectation that the prevalence and disease burden of the neglected tropical diseases (…
Accuracy of the WHO praziquantel dose pole for large-scale community treatment of urogenital schistosomiasis in northern Mozambique: Is it time for an update? Open
International Standard Randomized Controlled Trial registry under ISRTC number 14117624.
View article: “Rapid impact” 10 years after: The first “decade” (2006–2016) of integrated neglected tropical disease control
“Rapid impact” 10 years after: The first “decade” (2006–2016) of integrated neglected tropical disease control Open
New data from the Global Burden of Disease (GBD) Study 2016 indicate substantial declines in the prevalence and disease burden (as measured in disability-adjusted life years [DALYs]) of six of the seven neglected tropical diseases (NTDs) t…
View article: Latent class analysis to evaluate performance of point-of-care CCA for low-intensity Schistosoma mansoni infections in Burundi
Latent class analysis to evaluate performance of point-of-care CCA for low-intensity Schistosoma mansoni infections in Burundi Open
Whether measured in the laboratory or the field, CCA outperformed Kato-Katz at the low infection intensities in Burundi. CCA with trace as negative likely missed many infections, whereas CCA with trace as positive overestimated prevalence.…