Alan Halim
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View article: miR-10b as a Clinical Marker and a Therapeutic Target for Metastatic Breast Cancer
miR-10b as a Clinical Marker and a Therapeutic Target for Metastatic Breast Cancer Open
Despite advances in cancer detection and treatment, metastatic breast cancer continues to carry a poor prognosis due to the lack of diagnostic and therapeutic resources that are specific to the metastatic process. MicroRNA-10b (miR-10b) is…
View article: Inhibition of miR-10b treats metastatic breast cancer by targeting stem cell-like properties
Inhibition of miR-10b treats metastatic breast cancer by targeting stem cell-like properties Open
Despite advances in breast cancer screening and treatment, prognosis for metastatic disease remains dismal at 30% five-year survival. This is due, in large, to the failure of current therapeutics to target properties unique to metastatic c…
View article: Case report: MicroRNA-10b as a therapeutic target in feline metastatic mammary carcinoma and its implications for human clinical trials
Case report: MicroRNA-10b as a therapeutic target in feline metastatic mammary carcinoma and its implications for human clinical trials Open
Ninety percent of deaths from cancer are caused by metastasis. miRNAs are critical players in biological processes such as proliferation, metastasis, apoptosis, and self-renewal. We and others have previously demonstrated that miRNA-10b pr…
View article: Omniparticle Contrast Agent for Multimodal Imaging: Synthesis and Characterization in an Animal Model
Omniparticle Contrast Agent for Multimodal Imaging: Synthesis and Characterization in an Animal Model Open
View article: LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1
LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1 Open
View article: LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1
LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1 Open
Cholesterol is a critical component of membranes and a precursor for hormones and other signaling molecules. Previously, we showed that unlike astrocytes, glioblastoma cells do not downregulate cholesterol synthesis when plated at high den…
View article: p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling
p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling Open
View article: Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma
Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma Open
A hallmark of cellular transformation is the evasion of contact-dependent inhibition of growth. To find new therapeutic targets for glioblastoma, we looked for pathways that are inhibited by high cell density in astrocytes but not in gliom…