Alan H. Jobe
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View article: Intrauterine infection causes neuroinflammation and a selective loss of immature neurons in preterm non-human primate (NHP) fetuses 3227
Intrauterine infection causes neuroinflammation and a selective loss of immature neurons in preterm non-human primate (NHP) fetuses 3227 Open
Description Epidemiological data strongly links fetal exposure to chorioamnionitis with adverse infant neurological outcomes, but mechanisms are unknown. We developed a NHP model of chorioamnionitis resulting in fetal inflammation without …
View article: Adopting a consensus on the dose of antenatal steroids used by obstetric and neonatal services in Singapore in anticipation of imminent preterm birth
Adopting a consensus on the dose of antenatal steroids used by obstetric and neonatal services in Singapore in anticipation of imminent preterm birth Open
In Singapore, glucocorticoids are administered to pregnant women at risk of imminent preterm delivery. The primary desired benefit is maturation of the preterm fetal lung. The commonly used antenatal steroid regimen in Singapore, two doses…
View article: Reflections on the introduction of surfactant therapy for neonates with respiratory distress
Reflections on the introduction of surfactant therapy for neonates with respiratory distress Open
When pulmonary surfactant was first detected in the 1950s by Pattle and Clements, many thousands of infants perished each year due to a respiratory illness termed hyaline membrane disease. Hyaline membranes are formed by plasma leaking thr…
View article: IL-1 and TNF mediates IL-6 signaling at the maternal-fetal interface during intrauterine inflammation
IL-1 and TNF mediates IL-6 signaling at the maternal-fetal interface during intrauterine inflammation Open
Introduction IL6 signaling plays an important role in triggering labor and IL6 is an established biomarker of intrauterine infection/inflammation (IUI) driven preterm labor (PTL). The biology of IL6 during IUI at the maternal-fetal interfa…
View article: Dr. Tetsuro Fujiwara—My Memories from the Early Days of Dr. Fujiwara’s Research
Dr. Tetsuro Fujiwara—My Memories from the Early Days of Dr. Fujiwara’s Research Open
This brief commentary honors Dr. Tesuro Fujiwara, the first person to treat infants with respiratory distress syndrome by instilling surfactant into their trachea. In the 1960s, mortality from RDS, which could only be treated with oxygen, …
View article: Effects of multiple pro-inflammatory stimuli in utero on the ileum of extremely premature ovine fetuses
Effects of multiple pro-inflammatory stimuli in utero on the ileum of extremely premature ovine fetuses Open
Introduction Chorioamnionitis is common in preterm birth and associated with a higher risk of intestinal inflammation and necrotizing enterocolitis. The intestinal inflammation influences the enteric nervous system development. We hypothes…
View article: Preterm ovine respiratory epithelial cell responses to mechanical ventilation, lipopolysaccharide, and interleukin-13
Preterm ovine respiratory epithelial cell responses to mechanical ventilation, lipopolysaccharide, and interleukin-13 Open
Preterm lamb respiratory epithelial cells can be extracted from the trachea and bronchi and frozen, and the preterm cells can respond in culture to stimulation with LPS or IL-13. Brief mechanical ventilation changes the distribution and ce…
View article: Minimal <scp>physiologically‐based</scp> hybrid model of pharmacokinetics in pregnant women: Application to antenatal corticosteroids
Minimal <span>physiologically‐based</span> hybrid model of pharmacokinetics in pregnant women: Application to antenatal corticosteroids Open
Minimal physiologically‐based pharmacokinetic (mPBPK) models are an alternative to full physiologically‐based pharmacokinetic (PBPK) models as they offer reduced complexity while maintaining the physiological interpretation of key model co…
View article: Incidence of and Neurodevelopmental Outcomes After Late-Onset Meningitis Among Children Born Extremely Preterm
Incidence of and Neurodevelopmental Outcomes After Late-Onset Meningitis Among Children Born Extremely Preterm Open
Importance Late-onset meningitis (LOM) has been associated with adverse neurodevelopmental outcomes in children born extremely preterm. Objective To report the incidence of LOM during birth hospitalization and neurodevelopmental outcomes a…
View article: Antenatal corticosteroids in Singapore: a clinical and scientific assessment
Antenatal corticosteroids in Singapore: a clinical and scientific assessment Open
Preterm birth (PTB; delivery prior to 37 weeks’ gestation) is the leading cause of early childhood death in Singapore today. Approximately 9% of Singaporean babies are born preterm; the PTB rate is likely to increase given the increased us…
View article: Single nucleotide polymorphisms in surfactant protein <scp>A1</scp> are not associated with a lack of responsiveness to antenatal steroid therapy in a pregnant sheep model
Single nucleotide polymorphisms in surfactant protein <span>A1</span> are not associated with a lack of responsiveness to antenatal steroid therapy in a pregnant sheep model Open
Treatment with antenatal steroids (ANS) is standard practice for reducing the risk of respiratory distress in the preterm infant. Despite clear overall benefits when appropriately administered, many fetuses fail to derive benefit from ANS …
View article: Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques
Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques Open
Accurate estimate of fetal maturity could provide individualized guidance for delivery of complicated pregnancies. However, current methods are invasive, have low accuracy, and are limited to fetal lung maturation. To identify diagnostic g…
View article: Single-nucleus RNA-seq reveals disrupted cell maturation by chorioamnionitis in the preterm cerebellum of nonhuman primates
Single-nucleus RNA-seq reveals disrupted cell maturation by chorioamnionitis in the preterm cerebellum of nonhuman primates Open
Preterm birth is often associated with chorioamnionitis and increased risk of neurodevelopmental disorders. Preterm birth also leads to cerebellar underdevelopment but the mechanisms of disrupted cerebellar development in preterm infants a…
View article: The Journal of Pediatrics Turns 90! A Perspective on Progress, Opportunities, and Challenges
The Journal of Pediatrics Turns 90! A Perspective on Progress, Opportunities, and Challenges Open
This volume represents the 90th anniversary of The Journal of Pediatrics. In this commentary, current editors offer perspectives on the accomplishments, citing a few of the many seminal, high-impact articles published in The Journal over t…
View article: One percent of the clinical dose used for antenatal steroid therapy is sufficient to induce lung maturation when administered directly to the preterm ovine fetus
One percent of the clinical dose used for antenatal steroid therapy is sufficient to induce lung maturation when administered directly to the preterm ovine fetus Open
Antenatal steroids (ANSs) are routinely administered to women judged to be at imminent risk of preterm delivery. Their principal benefit is precocious functional maturation of the preterm fetal lung. Current dosing regimens expose the moth…
View article: Chorioamnionitis Causes Kidney Inflammation, Podocyte Damage, and Pro-fibrotic Changes in Fetal Lambs
Chorioamnionitis Causes Kidney Inflammation, Podocyte Damage, and Pro-fibrotic Changes in Fetal Lambs Open
Background Perinatal complications, such as prematurity and intrauterine growth restriction, are associated with increased risk of chronic kidney disease. Although often associated with reduced nephron endowment, there is also evidence of …
View article: Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates
Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates Open
Perinatal inflammatory stress is associated with early life morbidity and lifelong consequences for pulmonary health. Chorioamnionitis, an inflammatory condition affecting the placenta and fluid surrounding the developing fetus, affects 25…
View article: Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells
Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells Open
Atrial natriuretic peptide (ANP) and its receptors natriuretic peptide receptor (NPR)-A and NPR-C are all highly expressed in alveolar epithelial type II cells (AEC2s) in the late-gestation ovine fetal lung and are dramatically decreased p…