Alan Herschtal
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View article: Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes Open
Among patients with type 2 diabetes and atherosclerotic cardiovascular disease, tirzepatide was noninferior to dulaglutide with respect to a composite of death from cardiovascular causes, myocardial infarction, or stroke. (Funded by Eli Li…
Poisson Beta Regression for Count Data With an Application to Hospital Length of Stay Data Open
There has been growing awareness recently that conventional models for count data, such as the Negative Binomial model and zero inflated models, often yield poor fit and sub‐optimal performance when applied to real‐world count data problem…
Randomized Trial of Postoperative Radiation Therapy After Wide Excision of Neurotropic Melanoma of the Head and Neck (RTN2 Trial 01.09) Open
Background Cutaneous neurotropic melanoma (NM) of the head and neck (H&N) is prone to local relapse, possibly due to difficulties widely excising the tumor. This trial assessed radiation therapy (RT) to the primary site after local excisio…
View article: Advancing randomized controlled trial methodologies: The place of innovative trial design in eating disorders research
Advancing randomized controlled trial methodologies: The place of innovative trial design in eating disorders research Open
Randomized controlled trials can be used to generate evidence on the efficacy and safety of new treatments in eating disorders research. Many of the trials previously conducted in this area have been deemed to be of low quality, in part du…
Optimising radiation therapy delivery for cancer patients using daily image guidance to maximise cure and reduce normal tissue side effects Open
Cancer patients treated with radiotherapy are generally treated with a large number of small daily doses of radiation to the tumour region. The displacement of the tumour relative to its expected position each day prior to treatment can be…
Pop‐up screening nested within routine community activities unmasks an addressed cardiovascular risk: A pilot study (Gippsland Healthy Heart Study) Open
Objective To evaluate the benefits of a pop‐up health screening for cardiovascular risk factors (CVRF) in the Gippsland region, and to assess the acceptability of the screening and to determine whether such a process results in attendance …
View article: Adverse respiratory outcomes following conventional long‐course radiotherapy for non‐small‐cell lung cancer in patients with pre‐existing pulmonary fibrosis: A comparative retrospective study
Adverse respiratory outcomes following conventional long‐course radiotherapy for non‐small‐cell lung cancer in patients with pre‐existing pulmonary fibrosis: A comparative retrospective study Open
Introduction There is some evidence to suggest that patients with underlying pulmonary fibrosis (PF) have increased risk of adverse respiratory and survival outcomes, when treated with conventional, long‐course radiotherapy (RT) for non‐sm…
A Retrospective Evaluation of Risk of Peripartum Cardiac Dysfunction in Survivors of Childhood, Adolescent and Young Adult Malignancies Open
Long-term survivors of childhood, adolescent and young adult (AYA) malignancies with past exposure to potentially cardiotoxic treatments are at risk of peripartum cardiac dysfunction. Incidence and risk factors for peripartum cardiac dysfu…
View article: <sup>64</sup>Cu-SARTATE PET Imaging of Patients with Neuroendocrine Tumors Demonstrates High Tumor Uptake and Retention, Potentially Allowing Prospective Dosimetry for Peptide Receptor Radionuclide Therapy
<sup>64</sup>Cu-SARTATE PET Imaging of Patients with Neuroendocrine Tumors Demonstrates High Tumor Uptake and Retention, Potentially Allowing Prospective Dosimetry for Peptide Receptor Radionuclide Therapy Open
Imaging of somatostatin receptor expression is an established technique for staging of neuroendocrine neoplasia and determining the suitability of patients for peptide receptor radionuclide therapy. PET/CT using 68Ga-labeled somatostatin a…
A prospective randomized multicentre study of the impact of gallium‐68 prostate‐specific membrane antigen (PSMA) PET/CT imaging for staging high‐risk prostate cancer prior to curative‐intent surgery or radiotherapy (proPSMA study): clinical trial protocol Open
Background Accurate staging of patients with prostate cancer ( PC a) is important for therapeutic decision‐making. Relapse after surgery or radiotherapy of curative intent is not uncommon and, in part, represents a failure of staging with …
Surveillance imaging with FDG-PET/CT in the post-operative follow-up of stage 3 melanoma Open
As early detection of recurrent melanoma maximizes treatment options, patients usually undergo post-operative imaging surveillance, increasingly with FDG-PET/CT (PET). To assess this, we evaluated stage 3 melanoma patients who underwent pr…
The enhanced recovery after surgery (ERAS) Greenie Board: a Navy‐inspired quality improvement tool Open
Summary The United States Navy uses a visual feedback system for pilots, named ‘the Greenie Board’, to improve flight manoeuvres on aircraft carriers. Given that increased compliance with enhanced recovery after surgery protocols reduces p…
Outcomes of Australian patients receiving non‐funded anti‐PD‐1 immune checkpoint inhibitors for non‐melanoma cancers Open
Aim To characterize the outcomes of patients with nonmelanoma solid tumors receiving anti‐PD‐1 immunotherapy not funded by the Australian Pharmaceutical Benefits Scheme. Methods Medical records of patients with metastatic nonmelanoma tumor…
Unilateral radiotherapy treatment for p16/human papillomavirus–positive squamous cell carcinoma of unknown primary in the head and neck Open
Objectives/Hypothesis The outcomes of unilateral radiotherapy treatment for patients with p16/HPV‐positive squamous cell carcinomas of unknown primary (SCCUP) affecting cervical lymph nodes are under‐reported. Compared to radiating large v…
Variations of Surveillance Practice for Patients with Bone Sarcoma: A Survey of Australian Sarcoma Clinicians Open
Introduction . After treatment, bone sarcoma patients carry a high chance of relapse and late effects from multimodal therapy. We hypothesize that significant variation in surveillance practice exists between pediatric medical oncology (PO…
Subcutaneous Lidocaine Infusion for Pain in Patients with Cancer Open
Subcutaneous lidocaine infusions may be used safely in cancer pain management and is effective in some patients.
Excision margins and sentinel lymph node status as prognostic factors in thick melanoma of the head and neck: A retrospective analysis Open
Background Recommended margins for thick cutaneous melanoma (Breslow thickness >4 mm; T4) have decreased over recent decades. Optimal margins and the role of sentinel node biopsy (SNB) in thick head and neck melanoma remain controversial. …