Alan Hsu
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View article: Reconstructing Galaxy Cluster Mass Maps using Score-based Generative Modeling
Reconstructing Galaxy Cluster Mass Maps using Score-based Generative Modeling Open
We present a novel approach to reconstruct gas and dark matter projected density maps of galaxy clusters using score-based generative modeling. Our diffusion model takes in mock SZ and X-ray images as conditional inputs, and generates real…
View article: Algal bioactives: Unlocking future frontiers in respiratory therapeutics
Algal bioactives: Unlocking future frontiers in respiratory therapeutics Open
View article: Crucial role for iron metabolism in mediating influenza A virus infection and associated disease
Crucial role for iron metabolism in mediating influenza A virus infection and associated disease Open
Rationale and Objectives Iron availability and metabolism are important in the pathogenesis of bacterial infections. More recently, links have been reported between iron and the severity of viral infections. In this study, we characterize …
View article: Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease
Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease Open
View article: Endoplasmic reticulum stress enhances the expression of TLR3-induced TSLP by airway epithelium
Endoplasmic reticulum stress enhances the expression of TLR3-induced TSLP by airway epithelium Open
TSLP is an epithelial-derived cytokine and a key regulator in the pathogenesis of severe uncontrolled asthma. We demonstrate a novel mechanism by which endoplasmic reticulum stress signaling upregulates airway epithelial TSLP mRNA expressi…
View article: TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase
TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase Open
View article: Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor
Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor Open
The emergence of novel betacoronaviruses has posed significant financial and human health burdens, necessitating the development of appropriate tools to combat future outbreaks. In this study, we have characterized a human cell line, IGROV…
View article: Chronic exposure to low-level lipopolysaccharide dampens influenza-mediated inflammatory response via A20 and PPAR network
Chronic exposure to low-level lipopolysaccharide dampens influenza-mediated inflammatory response via A20 and PPAR network Open
Influenza A virus (IAV) infection leads to severe inflammation, and while epithelial-driven inflammatory responses occur via activation of NF-κB, the factors that modulate inflammation, particularly the negative regulators are less well-de…
View article: Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor
Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor Open
The emergence of novel betacoronaviruses has posed significant financial and human health burdens, necessitating the development of appropriate tools to combat future outbreaks. In this study, we have characterized a human cell line, IGROV…
View article: A Game of Infection – Song of Respiratory Viruses and Interferons
A Game of Infection – Song of Respiratory Viruses and Interferons Open
Humanity has experienced four major pandemics since the twentieth century, with the 1918 Spanish flu, the 2002 severe acute respiratory syndrome (SARS), the 2009 swine flu, and the 2019 coronavirus disease (COVID)-19 pandemics having the m…
View article: Proteomic Analysis Reveals a Novel Therapeutic Strategy Using Fludarabine for Steroid-Resistant Asthma Exacerbation
Proteomic Analysis Reveals a Novel Therapeutic Strategy Using Fludarabine for Steroid-Resistant Asthma Exacerbation Open
Virus-induced asthma exacerbation is a health burden worldwide and lacks effective treatment. To better understand the disease pathogenesis and find novel therapeutic targets, we established a mouse model of steroid (dexamethasone (DEX)) r…
View article: Airway Microbiome and Serum Metabolomics Analysis Identify Differential Candidate Biomarkers in Allergic Rhinitis
Airway Microbiome and Serum Metabolomics Analysis Identify Differential Candidate Biomarkers in Allergic Rhinitis Open
Allergic rhinitis (AR) is a common heterogeneous chronic disease with a high prevalence and a complex pathogenesis influenced by numerous factors, involving a combination of genetic and environmental factors. To gain insight into the patho…
View article: Sputum Metabolomic Profiling Reveals Metabolic Pathways and Signatures Associated With Inflammatory Phenotypes in Patients With Asthma
Sputum Metabolomic Profiling Reveals Metabolic Pathways and Signatures Associated With Inflammatory Phenotypes in Patients With Asthma Open
Different inflammatory asthma phenotypes have specific metabolic profiles in induced sputum. The potential metabolic signatures may identify therapeutic targets in different inflammatory asthma phenotypes.
View article: A Mouse Upper Respiratory Tract Coronavirus Infection Model with OC43 Defines Toll-Like Receptor 2/6 Mediated Innate Immune Protection
A Mouse Upper Respiratory Tract Coronavirus Infection Model with OC43 Defines Toll-Like Receptor 2/6 Mediated Innate Immune Protection Open
View article: A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis
A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis Open
Inhibition of cigarette smoke–induced microRNA-21 suppresses chronic obstructive pulmonary disease through effects on a SATB1/S100A9/NF-κB axis.
View article: Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization
Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization Open
View article: <scp>ACE2</scp> expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma
<span>ACE2</span> expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma Open
Background and objective COVID‐19 is complicated by acute lung injury, and death in some individuals. It is caused by SARS‐CoV‐2 that requires the ACE2 receptor and serine proteases to enter AEC. We determined what factors are associated w…
View article: The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders
The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders Open
Inflammation is the result of a complex network of cellular and molecular interactions and mechanisms that facilitate immune protection against intrinsic and extrinsic stimuli, particularly pathogens, to maintain homeostasis and promote ti…
View article: Design, synthesis and biological evaluation of novel pyxinol derivatives with anti-heart failure activity
Design, synthesis and biological evaluation of novel pyxinol derivatives with anti-heart failure activity Open
View article: SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors <i>in vitro</i>
SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors <i>in vitro</i> Open
Summary SARS-CoV-2 infection causes an inflammatory cytokine storm and acute lung injury. Currently there are no effective antiviral and/or anti-inflammatory therapies. Here we demonstrate that 2019 SARS-CoV-2 spike protein subunit 1 (CoV2…
View article: Human coronaviruses 229E and OC43 replicate and induce distinct antiviral responses in differentiated primary human bronchial epithelial cells
Human coronaviruses 229E and OC43 replicate and induce distinct antiviral responses in differentiated primary human bronchial epithelial cells Open
The recurrent emergence of novel, pathogenic coronaviruses (CoVs) severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1; 2002), Middle East respiratory syndrome (MERS)-CoV (2012), and most recently SARS-CoV-2 (2019) has highlighted t…
View article: TLR7 promotes smoke-induced lung damage through the activity of mast cell tryptase
TLR7 promotes smoke-induced lung damage through the activity of mast cell tryptase Open
The authors have withdrawn this preprint due to erroneous posting.
View article: TLR7 promotes smoke-induced lung damage through the activity of mast cell tryptase
TLR7 promotes smoke-induced lung damage through the activity of mast cell tryptase Open
Toll-like receptor (TLR)7 is known for eliciting immunity against single-stranded RNA viruses. TLR7 was increased in both human and cigarette smoke (CS)-induced experimental chronic obstructive pulmonary disease (COPD). Severity of CS-indu…
View article: ACE2 Expression is elevated in Airway Epithelial Cells from aged and male donors but reduced in asthma
ACE2 Expression is elevated in Airway Epithelial Cells from aged and male donors but reduced in asthma Open
Rationale COVID-19 is complicated by acute lung injury, and death in some individuals. It is caused by SARS-CoV-2 that requires the ACE2 receptor and serine proteases to enter airway epithelial cells (AECs). Objective To determine what fac…
View article: Green synthesis and antibacterial potential of artemisia vulgaris extract in silver nanoparticles against wound bacteria
Green synthesis and antibacterial potential of artemisia vulgaris extract in silver nanoparticles against wound bacteria Open
Background: Artemisia vulgaris (A. vulgaris), a well-known Chinese traditional herb, is a potential agent for wound healing. The herb is reported for its antibacterial properties and is commonly used to control bleeding in women. In our pr…
View article: Molecular mechanisms of action of naringenin in chronic airway diseases
Molecular mechanisms of action of naringenin in chronic airway diseases Open
View article: Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics
Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics Open
Gastric ulcer (GU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Finding a natural drug with a gastroprotective effect is needed. Ocotillol, the derivate of ocotillol-type saponins in the Pa…
View article: Ginsenoside Rg3 ameliorates acute exacerbation of COPD by suppressing neutrophil migration
Ginsenoside Rg3 ameliorates acute exacerbation of COPD by suppressing neutrophil migration Open
Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) is an irreversible inflammatory airways disease responsible for global health burden, involved with a complex condition of immunological change. Exacerbation-mediated neu…
View article: Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases
Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases Open
View article: Nasal epithelial cells to assess in vitro immune responses to respiratory virus infection in pregnant women with asthma
Nasal epithelial cells to assess in vitro immune responses to respiratory virus infection in pregnant women with asthma Open