Alan J. Young
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View article: Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays
Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays Open
Scrapie is diagnosed antemortem in sheep by detecting misfolded isoforms of prion protein (PrP(Sc)) in lymphoid follicles of the rectal mucosa and nictitating membranes. Assay sensitivity is limited if (a) the biopsy is collected early dur…