Alan Kavšek
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View article: Repurposing of aging‐preventive pharmaceuticals to delay Alzheimer's disease progression.
Repurposing of aging‐preventive pharmaceuticals to delay Alzheimer's disease progression. Open
Background Aging is the main risk factor for Alzheimer’s disease (AD). Several approved drugs currently used to treat conditions such as high blood pressure and diabetes may also influence the aging process, holding significant potential t…
View article: Repurposing drugs that slow down aging for the prevention of Alzheimer’s disease
Repurposing drugs that slow down aging for the prevention of Alzheimer’s disease Open
Background High age is the biggest risk factor for Alzheimer’s disease (AD). Approved drugs that slow down the aging process have the potential to be repurposed for the primary prevention of AD. The aim of our project was to use a reverse …
View article: A human progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans
A human progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans Open
Alterations in the nuclear envelope are linked to a variety of rare diseases termed laminopathies. A single amino acid substitution at position 12 (A12T) of the human nuclear envelope protein BAF (Barrier to Autointegration Factor) causes …
View article: A progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in <i>C. elegans</i>
A progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in <i>C. elegans</i> Open
Alterations in the nuclear envelope are linked to a variety of rare diseases termed laminopathies. These include both tissue specific and systemic diseases. A single amino acid substitution in human barrier to autointegration factor (BAF) …
View article: Primary cilia promote the differentiation of human neurons through the WNT signaling pathway
Primary cilia promote the differentiation of human neurons through the WNT signaling pathway Open
Background Primary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell’s immediate environment: signal reception and transduction to/from the ciliated cell. Deregulation of cilia…
View article: Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in <i>Saccharomyces cerevisiae</i>
Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in <i>Saccharomyces cerevisiae</i> Open
In 10–15% of cancers, telomere length is maintained by a telomerase-independent, recombination-mediated pathway called alternative lengthening of telomeres (ALT). ALT mechanisms were first seen, and have been best studied, in telomerase-nu…