Alan C. Kwan
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The Impact of Social Determinants of Health on Metabolic Dysfunction-Associated Steatotic Liver Disease Among Adults in the United States Open
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease. It has known multifactorial pathophysiology, but the impact of social determinants of health (SDOH) on the…
View article: Impact of Cancer Subtype and Cancer Therapy Exposures on <scp>SARS</scp>‐<scp>CoV</scp>‐2 Outcomes in the Omicron and Subvariant Era
Impact of Cancer Subtype and Cancer Therapy Exposures on <span>SARS</span>‐<span>CoV</span>‐2 Outcomes in the Omicron and Subvariant Era Open
Introduction Amidst highly transmissible SARS‐CoV‐2 variants that continue to circulate in the community, individuals with cancer exhibit variations in immunity and susceptibility for reasons that remain poorly understood. Methods In a lon…
View article: AI-based Hepatic Steatosis Detection and Integrated Hepatic Assessment from Cardiac CT Attenuation Scans Enhances All-cause Mortality Risk Stratification: A Multi-center Study
AI-based Hepatic Steatosis Detection and Integrated Hepatic Assessment from Cardiac CT Attenuation Scans Enhances All-cause Mortality Risk Stratification: A Multi-center Study Open
Summary Background Hepatic steatosis (HS) is a common cardiometabolic risk factor frequently present but under-diagnosed in patients with suspected or known coronary artery disease. We used artificial intelligence (AI) to automatically qua…
View article: Understanding Transient Left Ventricular Ejection Fraction Reduction During Atrial Fibrillation With Artificial Intelligence
Understanding Transient Left Ventricular Ejection Fraction Reduction During Atrial Fibrillation With Artificial Intelligence Open
Background Atrial fibrillation (AF) can cause a reduction in left ventricular ejection fraction (LVEF) that resolves rapidly upon restoration of sinus rhythm. We used artificial intelligence to understand (1) how often transient LVEF reduc…
View article: Automated Deep Learning Phenotyping of Tricuspid Regurgitation in Echocardiography
Automated Deep Learning Phenotyping of Tricuspid Regurgitation in Echocardiography Open
Importance Accurate assessment of tricuspid regurgitation (TR) is necessary for identification and risk stratification. Objective To design a deep learning computer vision workflow for identifying color Doppler echocardiogram videos and ch…
Artificial Intelligence Prediction of Age from Echocardiography as a Marker for Cardiovascular Disease Open
Accurate understanding of biological aging and the impact of environmental stressors is crucial for understanding cardiovascular health and identifying patients at risk for adverse outcomes. Chronological age stands as perhaps the most uni…
Opportunistic Screening of Chronic Liver Disease with Deep-Learning–Enhanced Echocardiography Open
Deep-learning assessment of clinical echocardiography enables opportunistic screening for SLD and cirrhosis. The application of this algorithm can identify patients who may benefit from further diagnostic testing and treatment for CLD. (Fu…
Sex-Divergent Blood Pressure Associations With Multiorgan System Metabolic Stress—Brief Report Open
BACKGROUND: Women experience excess cardiovascular risk compared with men in the setting of similar metabolic disease burden. We aimed to examine sex differences in the vascular response to various forms of metabolic stress. METHODS: We co…
Advances in the diagnosis of colorectal cancer: the application of molecular biomarkers and imaging techniques: a literature review Open
Background: Following neoplasms of the lung and breast, colorectal cancer (CRC) is the third most frequent malignancy globally. Screening for CRC at the age of 50 years is strongly encouraged for prompt earlier diagnosis owing to prognoses…
Using deep learning to predict cardiovascular magnetic resonance findings from echocardiography videos Open
Background Echocardiography is the most common modality for assessing cardiac structure and function. While cardiac magnetic resonance (CMR) imaging is less accessible, CMR can provide unique tissue characterization including late gadolini…
View article: Patient-Specific Myocardial Infarction Risk Thresholds From AI-Enabled Coronary Plaque Analysis
Patient-Specific Myocardial Infarction Risk Thresholds From AI-Enabled Coronary Plaque Analysis Open
BACKGROUND: Plaque quantification from coronary computed tomography angiography has emerged as a valuable predictor of cardiovascular risk. Deep learning can provide automated quantification of coronary plaque from computed tomography angi…
View article: Impact of epicardial fat on coronary vascular function, cardiac morphology, and cardiac function in women with suspected INOCA
Impact of epicardial fat on coronary vascular function, cardiac morphology, and cardiac function in women with suspected INOCA Open
Aims Epicardial fat is a metabolically active adipose tissue depot situated between the myocardium and visceral pericardium that covers ∼80% of the heart surface. While epicardial fat has been associated with the development of atheroscler…
Clinical and genetic associations of asymmetric apical and septal left ventricular hypertrophy Open
Aims Increased left ventricular mass has been associated with adverse cardiovascular outcomes including incident cardiomyopathy and atrial fibrillation. Such associations have been studied in relation to total left ventricular hypertrophy,…
Deep Learning Phenotyping of Tricuspid Regurgitation for Automated High Throughput Assessment of Transthoracic Echocardiography Open
Background and Aims Diagnosis of tricuspid regurgitation (TR) requires careful expert evaluation. This study developed an automated deep learning pipeline for assessing TR from transthoracic echocardiography. Methods An automated deep lear…
Opportunistic Screening of Chronic Liver Disease with Deep Learning Enhanced Echocardiography Open
Importance Chronic liver disease affects more than 1.5 billion adults worldwide, however the majority of cases are asymptomatic and undiagnosed. Echocardiography is broadly performed and visualizes the liver; but this information is not le…
View article: Alternating <scp>low‐rank</scp> tensor reconstruction for improved multiparametric mapping with cardiovascular <scp>MR</scp> Multitasking
Alternating <span>low‐rank</span> tensor reconstruction for improved multiparametric mapping with cardiovascular <span>MR</span> Multitasking Open
Purpose To develop a novel low‐rank tensor reconstruction approach leveraging the complete acquired data set to improve precision and repeatability of multiparametric mapping within the cardiovascular MR Multitasking framework. Methods A n…
Multi-Organ System Metabolic Stress and Sex-Divergent Vascular Associations Open
Introduction Women experience excess cardiovascular risk compared to men in the setting of similar metabolic disease burden. This consistent finding could be related to sex differences in the vascular response to various forms of metabolic…
View article: Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes
Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes Open
OBJECTIVE To investigate whether the sex disparities in type 2 diabetes–associated cardiovascular disease (CVD) risks may be related to early-onset hypertension that could benefit from intensive blood pressure (BP) control. RESEARCH DESIGN…
View article: Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes Mellitus
Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes Mellitus Open
Objective. To investigate whether the sex disparities in type 2 diabetes associated cardiovascular disease (CVD) risks may be related to early-onset hypertension that could benefit from intensive blood pressure (BP) control.Research Design…
View article: Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes Mellitus
Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes Mellitus Open
Objective. To investigate whether the sex disparities in type 2 diabetes associated cardiovascular disease (CVD) risks may be related to early-onset hypertension that could benefit from intensive blood pressure (BP) control.Research Design…
Using Deep learning to Predict Cardiovascular Magnetic Resonance Findings from Echocardiography Videos Open
Background Echocardiography is the most common modality for assessing cardiac structure and function. While cardiac magnetic resonance (CMR) imaging is less accessible, CMR can provide unique tissue characterization including late gadolini…
Point of Care Ultrasound for Diagnosis and Management in Heart Failure: A Targeted Literature Review Open
Background: Cardiac point of care ultrasound (POCUS) has shown increasing utility as a tool for diagnosing and managing heart failure (HF). Within cardiology, volume assessment leveraging visualization of the inferior (IVC) is a central as…