Alan L. Munn
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View article: Unmasking the tumorigenic potential of cellular prion protein in cancer progression
Unmasking the tumorigenic potential of cellular prion protein in cancer progression Open
The cellular prion protein (PrPC), altered forms of which are associated with neurological prion disorders, is overexpressed in gastric, breast, prostate, and colorectal cancer. Its overexpression affects cell proliferation, migration, and…
View article: Bacterial ghosts: A breakthrough approach to cancer vaccination
Bacterial ghosts: A breakthrough approach to cancer vaccination Open
Cancer is a devastating disease worldwide with high mortality rates and is a foremost concern for society. Immunotherapy has emerged as a promising strategy for treating cancer, harnessing the power of immune system to recognize and kill t…
View article: New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review)
New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review) Open
Therapeutic approaches that increase the efficacy and safety of cancer treatments and improve disease outcomes have been developed worldwide. Immunotherapy uses the body's immune system to inhibit cancerous growth in tissues and organs. Va…
View article: WHEN CLITIC SYSTEMS COLLIDE, ANIMACY, FOR THE MOST PART, BEATS GENDER
WHEN CLITIC SYSTEMS COLLIDE, ANIMACY, FOR THE MOST PART, BEATS GENDER Open
In this paper we present elicitation results from an experiment on the acquisition of 3rd person object clitics by children of Paraguayan parents living in Buenos Aires and their mothers. These children are immersed in a situation of conta…
View article: Conserved bacterial de novo guanine biosynthesis pathway enables microbial survival and colonization in the environmental niche of the urinary tract
Conserved bacterial de novo guanine biosynthesis pathway enables microbial survival and colonization in the environmental niche of the urinary tract Open
In bacteria, guaA encodes guanosine monophosphate synthetase that confers an ability to biosynthesize guanine nucleotides de novo. This enables bacterial colonization in different environments and, while guaA is widely distributed among Ba…
View article: Anti-prion and α-Synuclein Aggregation Inhibitory Sterols from the Sponge <i>Lamellodysidea</i> cf. <i>chlorea</i>
Anti-prion and α-Synuclein Aggregation Inhibitory Sterols from the Sponge <i>Lamellodysidea</i> cf. <i>chlorea</i> Open
In a study aimed at identifying new anti-prion compounds we screened a library of 500 Australian marine invertebrate derived extracts using a yeast-based anti-prion assay. This resulted in an extract from the subtropical sponge Lamellodysi…
View article: Yeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals—Illustrated with Four Actin Cytoskeleton Proteins
Yeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals—Illustrated with Four Actin Cytoskeleton Proteins Open
The budding yeast Saccharomyces cerevisiae has an actin cytoskeleton that comprises a set of protein components analogous to those found in the actin cytoskeletons of higher eukaryotes. Furthermore, the actin cytoskeletons of S. cerevisiae…
View article: Anti-prion Butenolides and Diphenylpropanones from the Australian Ascidian <i>Polycarpa procera</i>
Anti-prion Butenolides and Diphenylpropanones from the Australian Ascidian <i>Polycarpa procera</i> Open
A library of 500 Australian marine invertebrate extracts was screened for anti-prion activity using a yeast-based assay, and this resulted in an extract from the ascidian Polycarpa procera showing potent activity. Purification of this extr…
View article: <scp>EGFR</scp> and Prion protein promote signaling via <scp>FOXO</scp>3a‐<scp>KLF</scp>5 resulting in clinical resistance to platinum agents in colorectal cancer
<span>EGFR</span> and Prion protein promote signaling via <span>FOXO</span>3a‐<span>KLF</span>5 resulting in clinical resistance to platinum agents in colorectal cancer Open
Epidermal growth factor receptor ( EGFR ) supports colorectal cancer progression via oncogenic signaling. Anti‐ EGFR therapy is being investigated as a clinical option for colorectal cancer, and an observed interaction between EGFR and Pri…
View article: Yeast-based screening of natural product extracts results in the identification of prion inhibitors from a marine sponge
Yeast-based screening of natural product extracts results in the identification of prion inhibitors from a marine sponge Open
One of the major medical challenges of the twenty-first century is the treatment of incurable and fatal neurodegenerative disorders caused by misfolded prion proteins. Since the discovery of these diseases a number of studies have been con…
View article: Prion protein scrapie and the normal cellular prion protein
Prion protein scrapie and the normal cellular prion protein Open
Prions are infectious proteins and over the past few decades, some prions have become renowned for their causative role in several neurodegenerative diseases in animals and humans. Since their discovery, the mechanisms and mode of transmis…