Alan Lenarcic
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View article: Next generation connectivity: a review of broadband internet transitions and policy from around the world
Next generation connectivity: a review of broadband internet transitions and policy from around the world Open
This report documents a study by the Berkman Center for Internet and Society at Harvard University to review international experiences with broadband and plans for next generation connectivity. The most prominent initial findings were that…
View article: Genetic Architecture of Skewed X Inactivation in the Laboratory Mouse
Genetic Architecture of Skewed X Inactivation in the Laboratory Mouse Open
X chromosome inactivation (XCI) is the mammalian mechanism of dosage compensation that balances X-linked gene expression between the sexes. Early during female development, each cell of the embryo proper independently inactivates one of it…
View article: A General Bayesian Approach to Analyzing Diallel Crosses of Inbred Strains
A General Bayesian Approach to Analyzing Diallel Crosses of Inbred Strains Open
The classic diallel takes a set of parents and produces offspring from all possible mating pairs. Phenotype values among the offspring can then be related back to their respective parentage. When the parents are diploid, sexed, and inbred,…
View article: Genetics of Adverse Reactions to Haloperidol in a Mouse Diallel: A Drug–Placebo Experiment and Bayesian Causal Analysis
Genetics of Adverse Reactions to Haloperidol in a Mouse Diallel: A Drug–Placebo Experiment and Bayesian Causal Analysis Open
Haloperidol is an efficacious antipsychotic drug that has serious, unpredictable motor side effects that limit its utility and cause noncompliance in many patients. Using a drug–placebo diallel of the eight founder strains of the Collabora…
View article: Developmental Bias in Cleavage-Stage Mouse Blastomeres
Developmental Bias in Cleavage-Stage Mouse Blastomeres Open
The cleavage stage mouse embryo is composed of superficially equivalent blastomeres that will generate both the embryonic inner cell mass (ICM) and the supportive trophectoderm (TE). However, it remains unsettled whether the contribution o…
View article: Algorithmic Bayesian Group Gibbs Selection
Algorithmic Bayesian Group Gibbs Selection Open
Bayesian model selection, with precedents in George and McCulloch (1993) and Abramovich et al. (1998), support credibility measures that relate model uncertainty, but computation can be costly when sparse priors are approximate. We design …
View article: Bayesian Manifold-Constrained-Prior Model for an Experiment to Locate Xce
Bayesian Manifold-Constrained-Prior Model for an Experiment to Locate Xce Open
We propose an analysis for a novel experiment intended to locate the genetic locus Xce (X-chromosome controlling element), which biases the stochastic process of X-inactivation in the mouse. X-inactivation bias is a phenomenon where cells …