Alan C. Moss
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View article: Introduction to the <i>IBD</i> Journal Supplement: “Prevention of IBD: Forecasting and Forestalling Inflammatory Bowel Disease Onset”
Introduction to the <i>IBD</i> Journal Supplement: “Prevention of IBD: Forecasting and Forestalling Inflammatory Bowel Disease Onset” Open
Despite significant therapeutic advances in inflammatory bowel disease (IBD), patients still experience diagnostic delays, suboptimal outcomes, and low remission rates—highlighting the urgent need for new approaches. This IBD journal suppl…
View article: Research priorities for cancers of the oesophagus and stomach: recommendations from a UK and Ireland patient and healthcare professional partnership exercise
Research priorities for cancers of the oesophagus and stomach: recommendations from a UK and Ireland patient and healthcare professional partnership exercise Open
Background Cancers of the oesophagus and stomach are a major cause of morbidity and mortality. Research is crucial to improving outcomes. However, to maximise value and impact, areas of focus should be prioritised in partnership with patie…
View article: Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms
Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms Open
Preclinical human inflammatory bowel disease (IBD) mechanisms is one of 5 focus areas of the Challenges in IBD Research 2024 document, which also includes environmental triggers, novel technologies, precision medicine, and pragmatic clinic…
Challenges in IBD Research 2024: Novel Technologies Open
Novel technology is one of the five focus areas of the Challenges in Inflammatory Bowel Disease (IBD) Research 2024 document. Building off the Challenges in IBD Research 2019 document, the Foundation aims to provide a comprehensive overvie…
View article: Challenges in IBD Research 2024: Precision Medicine
Challenges in IBD Research 2024: Precision Medicine Open
Precision medicine is part of 5 focus areas of the Challenges in IBD Research 2024 research document, which also includes preclinical human IBD mechanisms, environmental triggers, novel technologies, and pragmatic clinical research. Buildi…
Overview to Challenges in IBD 2024–2029 Open
The mission of the Crohn’s & Colitis Foundation is to cure Crohn’s disease and ulcerative colitis and to improve the quality of lives of patients living with these diseases—in other words, to care and cure. To achieve these missions, there…
View article: Challenges in IBD Research 2024: Pragmatic Clinical Research
Challenges in IBD Research 2024: Pragmatic Clinical Research Open
Pragmatic clinical research is 1 of the 5 focus areas of the Challenges in IBD Research 2024, a multidisciplinary effort by scientists, clinicians, patients, and funders to identify priorities for patient-centric research. This summary pro…
Medical management of painful achalasia: a patient-driven systematic review Open
Summary Achalasia is a rare esophageal disorder characterized by abnormal esophageal motility and swallowing difficulties. Pain and/or spasms often persist or recur despite effective relief of the obstruction. A survey by UK charity ‘Achal…
François de Meyer’s Fish Travelogue (1698) Open
This chapter presents and contextualizes the ichthyological information given in a French manuscript travelogue written by a certain François de Meyer, of whom almost nothing is known. This travelogue, which relates the author’s voyage fro…
Low-Dose Interleukin 2 for the Treatment of Moderate to Severe Ulcerative Colitis Open
Ulcerative colitis (UC) represents an inflammatory condition of the human colon believed in part to be mediated by dysregulation of the host immune system including potentially inadequate mucosal regulatory T-cell (Treg) responses.1Chang J…
Supplementary Figures S1-S2 from SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer Open
Supplementary Figures S1-S2 from SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer
Data from SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer Open
Purpose: Specific markers of circulating tumor cells may be informative in managing lung cancer. Because the RE-1 silencing transcription factor (REST/NRSF) is a transcriptional repressor that is inactivated in neuroendocrine lung cancer, …
Data from SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer Open
Purpose: Specific markers of circulating tumor cells may be informative in managing lung cancer. Because the RE-1 silencing transcription factor (REST/NRSF) is a transcriptional repressor that is inactivated in neuroendocrine lung cancer, …
Supplementary Figures S1-S2 from SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer Open
Supplementary Figures S1-S2 from SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer
View article: UEG and EAES rapid guideline: Update systematic review, network meta‐analysis, CINeMA and GRADE assessment, and evidence‐informed European recommendations on surgical management of GERD
UEG and EAES rapid guideline: Update systematic review, network meta‐analysis, CINeMA and GRADE assessment, and evidence‐informed European recommendations on surgical management of GERD Open
Background There are several options for the surgical management of GERD in adults. Previous guidelines and systematic reviews have compared the effects of total fundoplication versus pooled effects of different techniques of partial fundo…
IDENTIFYING BARRIERS TO HEALTH MAINTENANCE IN MEDICALLY-UNDERSERVED PATIENTS WITH IBD: A QUALITATIVE STUDY Open
BACKGROUND Disparities in adherence to health maintenance recommendations have been well-documented in patients with IBD. Solutions to address these issues remain under-described or evaluated. We sought to engage at-risk patients with IBD …
Health Maintenance Consensus for Adults With Inflammatory Bowel Disease Open
Background With the management of inflammatory bowel disease (IBD) becoming increasingly complex, incorporating preventive care health maintenance measures can be challenging. The aim of developing these updated recommendations is to provi…
Exosomes in Intestinal Inflammation Open
Exosomes are 30–150 nm sized vesicles released by a variety of cells, and are found in most physiological compartments (feces, blood, urine, saliva, breast milk). They can contain different cargo, including nucleic acids, proteins and lipi…
View article: Development of Entrustable Professional Activities for Advanced Inflammatory Bowel Disease Fellowship Training in the United States
Development of Entrustable Professional Activities for Advanced Inflammatory Bowel Disease Fellowship Training in the United States Open
Background The level of inflammatory bowel disease (IBD) training in general gastroenterology fellowship is often insufficient to prepare trainees to deliver advanced IBD care in practice. Advanced IBD fellowships have been developed to fi…
Management of Asymptomatic Terminal Ileitis Open
Ileal intubation is often performed during screening colonoscopies. This had led to the recognition of mild ileitis in many asymptomatic patients. The natural history and clinical significance of this finding are not well established, and …
A novel distinctive form of identification for differential diagnosis of irritable bowel syndrome, inflammatory bowel disease, and healthy controls Open
Background\n\t\t\t\t Irritable bowel syndrome (IBS) is a functional disorder affecting around 11% of the world population, which diagnostic is mainly based on clinical parameters. IBS shares many symptoms with other gastrointestinal disord…
Impact of Clinical Pharmacists in Inflammatory Bowel Disease Centers During the COVID-19 Pandemic Open
INTRODUCTION: To characterize the clinical pharmacists' impact on caring for patients with inflammatory bowel disease during COVID-19. METHODS: A clinical pharmacist's encounters between March 17 and April 14, 2020, were audited to determi…
Implications of recurrent SARS-CoV-2 outbreaks for IBD management Open
The initial phases of the global SARS-CoV2 pandemic had significant implications for the management of patients with inflammatory bowel disease (IBD). This impact is likely to be sustained and far-reaching across all models of care. Initia…