Explanipedia

Noninvasive Vagus Nerve Stimulation Reduces Withdrawal-Related Affective Distress and Improves Functional Outcomes in Alcohol Use Disorder: A Feasibility and Acceptability Pilot Study Open

Ruth Klaming, Katia M. Harlé, Imanuel Lerman, Sonya B. Norman, Irina A. Strigo , et al. · 2025

To our knowledge, this is the first study to explore cervical nVNS as a potential new treatment for AUD-related symptoms. Findings provide support for feasibility of treatment delivery and patient acceptance, and initial evidence that nVNS…

Bayesian deconvolution for computational cognitive modeling of fMRI data Open

Jonathon R. Howlett, Katia M. Harlé, Alan N. Simmons, Charles T. Taylor · 2025

A central goal of cognitive neuroscience is to make inferences about underlying cognitive processes from observable data. However, current fMRI analysis tools cannot directly estimate latent parameters in computational cognitive models fro…

A randomized controlled trial of computerized cognitive training to improve working memory in individuals with elevated repetitive negative thinking: Behavioral and neural outcomes Open

Jessica Bomyea, Morgan M. Caudle, Nathalie Dugas, Raeanne C. Moore, Alan N. Simmons , et al. · 2024

Randomized controlled trial of computerized working memory training for Veterans with PTSD Open

Jessica Bomyea, Morgan M. Caudle, A L Bartolovich, Alan N. Simmons, Amy J. Jak , et al. · 2024

Posttraumatic stress disorder (PTSD) is a common psychiatric condition among Veterans that is associated with deficits across a range of neuropsychological domains including working memory. While gold-standard psychosocial treatments are h…

Enhancing chronic low back pain management: an initial neuroimaging study of a mobile interoceptive attention training Open

Irina A. Strigo, Sergio Garcia Guerra, Salvatore Torrisi, Emily Murphy, Tiffany Toor , et al. · 2024

Introduction Chronic low back pain (cLBP) poses significant challenges, often addressed through avoidance or distraction. Emerging evidence suggests that mind-body interventions, like our novel Mind Your Pain (MyP) smartphone mobile applic…

Biological markers of brain network connectivity and pain sensitivity distinguish low coping from high coping Veterans with persistent post-traumatic headache Open

K Monroe, Dawn M. Schiehser, Aaron W. Parr, Alan N. Simmons, Chelsea C. Hays Weeks , et al. · 2024

Headache is the most common type of pain following mild traumatic brain injury. Roughly half of those with persistent post-traumatic headache (PPTH) also report neck pain which is associated with greater severity and functional impact of h…

Assessing social anhedonia in a transdiagnostic sample: Insights from a computational psychiatry lens. Open

Katia M. Harlé, Danielle N. Dun, Andrea D. Spadoni, Jonathon R. Howlett, Alan N. Simmons · 2024

Non-invasive ventral cervical magnetoneurography as a proxy of in vivo lipopolysaccharide-induced inflammation Open

Yifeng Bu, J. Alton Burks, Kun Yang, Jacob Prince, Amir Borna , et al. · 2024

Change in Resting-State Functional Connectivity Following Working Memory Training in Individuals With Repetitive Negative Thinking Open

Jessica Bomyea, Shirley Feng, Raeanne C. Moore, Alan N. Simmons, Michael L. Thomas · 2024

These data provide evidence that working memory training can modulate neural circuitry at rest in individuals with RNT. Results are consistent with accounts of working memory training effects on large-scale neurocircuitry changes and sugge…

Exploring the effects of fitbit incentive on treatment outcomes in veterans undergoing intensive pain rehabilitation program Open

Tiffany Toor, Sarah A. Palyo, Kathryn Schopmeyer, Alan N. Simmons, Irina A. Strigo · 2024

Motivational context and neurocomputation of stop expectation moderate early attention responses supporting proactive inhibitory control Open

Resh S. Gupta, Alan N. Simmons, Nathalie Dugas, Daniel M. Stout, Katia M. Harlé · 2024

Alterations in attention to cues signaling the need for inhibitory control play a significant role in a wide range of psychopathology. However, the degree to which motivational and attentional factors shape the neurocomputations of proacti…

Identification of group differences in predictive anticipatory biasing of pain during uncertainty: preparing for the worst but hoping for the best Open

Irina A. Strigo, Molly Kadlec, Jennifer Mitchell, Alan N. Simmons · 2024

Pain anticipation during conditions of uncertainty can unveil intrinsic biases, and understanding these biases can guide pain treatment interventions. This study used machine learning and functional magnetic resonance imaging to predict an…

34 Neurocomputational Mechanisms of Social Reward Processing in Combat-Exposed Veterans Open

Alex F. Skupny, Danielle N. Dun, Katia M. Harlé, Alan N. Simmons · 2023

Objective: Combat exposure is associated with higher rates of depressive symptoms, including anhedonia (i.e., a reduced ability to seek and experience rewards) and feelings of social disconnectedness. While these symptoms are commonly docu…

Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium Open

Xi Zhu, Yoojean Kim, Orren Ravid, Xiaofu He, Benjamin Suarez‐Jimenez , et al. · 2023

Amplification of Positivity Treatment for Anxiety and Depression: A Randomized Experimental Therapeutics Trial Targeting Social Reward Sensitivity to Enhance Social Connectedness Open

Charles T. Taylor, Murray B. Stein, Alan N. Simmons, Feng He, Christopher Oveis , et al. · 2023

Teaching people with anxiety or depression strategies to increase positive thoughts, behaviors, and emotions enhances activity in brain regions that govern social reward processing and promotes social connectedness. Social reward sensitivi…

Neural activity and network analysis for understanding reasoning using the matrix reasoning task Open

Morgan M. Caudle, Andrea D. Spadoni, Dawn M. Schiehser, Alan N. Simmons, Jessica Bomyea · 2023

Unsupervised learning for prognostic validity in patients with chronic pain in transdisciplinary pain care Open

Irina A. Strigo, Alan N. Simmons, Jameson Giebler, Jan M. Schilling, Tobias Moeller‐Bertram · 2023

State-specific alterations in the neural computations underlying inhibitory control in women remitted from bulimia nervosa Open

Laura A. Berner, Katia M. Harlé, Alan N. Simmons, Angela J. Yu, Martin P. Paulus , et al. · 2023

How Obstructed Action Efficacy Impacts Reward-Based Decision Making in Adolescent Depression: An fMRI Study Open

Katia M. Harlé, Tiffany C. Ho, Colm G. Connolly, Alan N. Simmons, Tony T. Yang · 2023

Adolescents with depression tend to exhibit less flexible behavioral orientation in the face of blocked action efficacy, and abnormalities in neural systems critical to regulating negative affect during reward-based decision making. This r…

Editorial: Understanding emotions using brain imaging and stimulation techniques Open

Alan N. Simmons, Irina A. Strigo · 2023

EDITORIAL article Front. Hum. Neurosci., 31 January 2023Sec. Brain Imaging and Stimulation Volume 17 - 2023 | https://doi.org/10.3389/fnhum.2023.1130140

Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group Open

Nynke A. Groenewold, Janna Marie Bas‐Hoogendam, Alyssa R. Amod, Max A. Laansma, Laura S. van Velzen , et al. · 2023

Multimodal Imaging-Based Classification of PTSD Using Data-Driven Computational Approaches: A Multisite Big Data Study from the ENIGMA-PGC PTSD Consortium Open

Xi Zhu, Yoojean Kim, Orren Ravid, Xiaofu He, Benjamin Suarez‐Jimenez , et al. · 2022

Background Current clinical assessments of Posttraumatic stress disorder (PTSD) rely solely on subjective symptoms and experiences reported by the patient, rather than objective biomarkers of the illness. Recent advances in data-driven com…

Distal neuropathic pain in HIV is associated with functional connectivity patterns in default mode and salience networks Open

Chelsea C. Hays Weeks, Alan N. Simmons, Irina A. Strigo, Sara Timtim, Ronald J. Ellis , et al. · 2022

HIV-associated distal neuropathic pain (DNP) is one of the most prevalent, disabling, and treatment-resistant complications of HIV, but its biological underpinnings are incompletely understood. While data specific to mechanisms underlying …

HIV peripheral neuropathy‐related degeneration of white matter tracts to sensorimotor cortex Open

Sara Timtim, Alan N. Simmons, Chelsea C. Hays, Irina A. Strigo, Scott F. Sorg , et al. · 2022

Human immunodeficiency virus-associated distal sensory polyneuropathy (HIV-DSP) affects up to 50% of people with HIV and is associated with depression, unemployment, and generally worsened quality of life. Previous work on the cortical mec…

Correction to: Deriving psychiatric symptom-based biomarkers from multivariate relationships between psychophysiological and biochemical measures Open

Daniel M. Stout, Alan N. Simmons, Caroline M. Nievergelt, Arpi Minassian, Nilima Biswas , et al. · 2022

A prospective investigation of youth alcohol experimentation and reward responsivity in the ABCD study Open

April C. May, Joanna Jacobus, Alan N. Simmons, Susan F. Tapert · 2022

Rationale Greater risk-taking behaviors, such as alcohol experimentation, are associated with different patterns of brain functioning in regions implicated in reward (nucleus accumbens, NA) and cognitive control (inferior frontal gyrus, IF…

Non-invasive cervical vagus nerve stimulation effects on reaction time and valence image anticipation response Open

Imanuel Lerman, Ruth Klaming, Andrea D. Spadoni, Dewleen G. Baker, Alan N. Simmons · 2022

nVNS was linked to reduced reaction time during the anticipation task. In tandem, nVNS consistently enhanced responsivity to negatively valenced images and diminished responsivity to positively valenced images, suggesting specific nVNS dri…

Toward Composite Pain Biomarkers of Neuropathic Pain—Focus on Peripheral Neuropathic Pain Open

Monica M. Diaz, Jacob Caylor, Irina A. Strigo, Imanuel Lerman, Brook L. Henry , et al. · 2022

Chronic pain affects ~10–20% of the U.S. population with an estimated annual cost of $600 billion, the most significant economic cost of any disease to-date. Neuropathic pain is a type of chronic pain that is particularly difficult to mana…

Toward Composite Pain Biomarkers of Neuropathic Pain—Focus on Peripheral Neuropathic Pain Open

Monica M. Diaz, Jacob Caylor, Irina A. Strigo, Imanuel Lerman, Brook L. Henry , et al. · 2022

Chronic pain affects ~10–20% of the U.S. population with an estimated annual cost of $600 billion, the most significant economic cost of any disease to-date. Neuropathic pain is a type of chronic pain that is particularly difficult to mana…

Understanding Pain and Trauma Symptoms in Veterans From Resting-State Connectivity: Unsupervised Modeling Open

Irina A. Strigo, Andrea D. Spadoni, Alan N. Simmons · 2022

Trauma and posttraumatic stress are highly comorbid with chronic pain and are often antecedents to developing chronic pain conditions. Pain and trauma are associated with greater utilization of medical services, greater use of psychiatric …

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