Alan P. Koretsky
YOU?
Author Swipe
Age-dependent integration of cortical progenitors transplanted at CSF-neurogenic niche interface Open
There has been renewed interest in neural transplantation of cells and tissues for brain repair. Recent studies have demonstrated the ability of transplanted neural precursor cells and in vitro grown organoids to mature and locally integra…
Direct delivery of MRI contrast through skull vessel/marrow pathways into the brain guided by microCT Open
Rationale: The brain remains a challenging organ for drug delivery. Earlier studies demonstrated that transcranial application of small molecular therapeutics and MRI contrast such as manganese ion (Mn2+) could serve as a new method for de…
Review of cocaine-induced brain vascular and cellular function changes measured in vivo with optical imaging Open
These findings on cocaine's effects on the neuro-astroglial-vascular network in the prefrontal cortex highlight the unique capacity of optical imaging to reveal the cellular and vascular mechanisms underlying cocaine's neurotoxic effects o…
View article: 500 MHz Inductive Birdcage RF Coil for Brain MRI: Design, Implementation and Validation
500 MHz Inductive Birdcage RF Coil for Brain MRI: Design, Implementation and Validation Open
This validation is important for future analysis of radiofrequency safety and performance at ultra-high field MRI through the prediction of SAR and $\text{B}_{1}^{+}$ profiles across different human brain models at various positions inside…
View article: Behavioral adaptations after unilateral whisker denervation
Behavioral adaptations after unilateral whisker denervation Open
The rodent whisker system provides an excellent model to study experience dependent plasticity in neural morphology, circuitry, and behavior. Rodents use bilateral whisker sensation to gather information about their environment. Unilateral…
Exploring cortical perivascular space as a biomarker in neurodegenerative diseases through optimized CSF‐only MRI at 7T Open
Background Detecting changes in perivascular spaces (PVS) holds promise as a biomarker for neurodegenerative diseases. These spaces exhibit increased protein accumulation and dilatation in neurodegenerative diseases even preceding symptoma…
Post-Critical Period Transcriptional and Physiological Adaptations of Thalamocortical Connections after Sensory Loss Open
Summary Abstract Figure Graphical Abstract Unilateral whisker denervation activates plasticity mechanisms and circuit adaptations in adults. Single nucleus RNA sequencing and multiplex fluorescence in situ hybridization revealed differenti…
Detection of Nanoliter-Scale Cortical Perivascular Spaces Using Heavily T<sub>2</sub>-weighted MRI at 7T Open
Background There is increasing interest in high-contrast cerebrospinal fluid (CSF) MRI to image perivascular spaces (PVSs). Dilated PVSs, associated with aging, dementia, and various other conditions, have been commonly detected within the…
Age Dependent Integration of Cortical Progenitors Transplanted at the Adult CSF-Brain Interface Open
There has been renewed interest in neural transplantation of cells and tissues for brain repair. Recent studies have demonstrated the ability of transplanted neural precursor cells and in vitro grown organoids to mature and locally integra…
View article: Postmortem MRI of Tissue Frozen at Autopsy
Postmortem MRI of Tissue Frozen at Autopsy Open
Introduction Postmortem MRI provides insight into location of pathology within tissue blocks, enabling efficient targeting of histopathological studies. While postmortem imaging of fixed tissue is gaining popularity, imaging tissue frozen …
High iron in mouse olfactory ensheathing cells at the glia limitans in the olfactory bulb underlies MRI T2* hypointensity Open
Brain iron is important for normal function, and aberrantly high iron is often associated with neuroinflammation and neurodegeneration. Oligodendrocytes are a major source of iron in brain as are iron-laden activated macrophages and microg…
Genetic control of MRI contrast using the manganese transporter Zip14 Open
These are the primary data described in our paper titled "Genetic control of MRI contrast using the manganese transporter Zip14". The MRI data are organized into the following file hierarchy:Injected virus. The filename is structured: 'Cap…
Author response: Early detection of cerebrovascular pathology and protective antiviral immunity by MRI Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Central nervous system…
Cover Image Open
COVER ILLUSTRATION This figure highlights a subject with a colloid cyst (annotated by red lines) among more than 15,000 UK Biobank subjects (the structural images of all the subjects were tiled together to form the background image). This …
Lamina-specific immunohistochemical signatures in the olfactory bulb of healthy, Alzheimer’s and Parkinson’s disease patients Open
Traditional neuroanatomy immunohistology studies involve low-content analyses of a few antibodies of interest, typically applied and compared across sequential tissue sections. The efficiency, consistency, and ultimate insights of these st…
Outlier detection in multimodal <span>MRI</span> identifies rare individual phenotypes among more than 15,000 brains Open
Outliers in neuroimaging represent spurious data or the data of unusual phenotypes that deserve special attention such as clinical follow‐up. Outliers have usually been detected in a supervised or semi‐supervised manner for labeled neuroim…
Optimization of pseudo‐continuous arterial spin labeling using off‐resonance compensation strategies at 7T Open
Purpose The sensitivity of pseudo‐continuous arterial spin labeling (PCASL) to off‐resonance effects (ΔB 0 ) is a major limitation at ultra‐high field (≥7T). The aim of this study was to assess the effectiveness of different PCASL ΔB 0 com…
Early detection of cerebrovascular pathology and protective antiviral immunity by MRI Open
Central nervous system (CNS) infections are a major cause of human morbidity and mortality worldwide. Even patients that survive CNS infections can have lasting neurological dysfunction resulting from immune and pathogen induced pathology.…
Outlier detection in multimodal MRI identifies rare individual phenotypes among 20,000 brains Open
Outliers in neuroimaging represent spurious data or the data of unusual phenotypes that deserve special attention such as clinical follow-up. Outliers have usually been detected in a supervised or semi-supervised manner for labeled neuroim…
A hierarchy of manganese competition and entry in organotypic hippocampal slice cultures Open
Contrast agents improve clinical and basic research MRI. The manganese ion (Mn 2+ ) is an essential, endogenous metal found in cells and it enhances MRI contrast because of its paramagnetic properties. Manganese‐enhanced MRI (MEMRI) has be…
View article: Microvascular Injury in the Brains of Patients with Covid-19
Microvascular Injury in the Brains of Patients with Covid-19 Open
Microvascular Changes in the Brain in Covid-19 High-resolution MRI and histopathological study of the brains of patients who had died from Covid-19 showed punctate hyperintensities and punctate or ...
Circuit-Specific Plasticity of Callosal Inputs Underlies Cortical Takeover Open
Injury induces synaptic, circuit, and systems reorganization. After unilateral amputation or stroke, this functional loss disrupts the interhemispheric interaction between intact and deprived somatomotor cortices to recruit deprived cortex…