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View article: Prognostic Impact of Cardiovascular‐Kidney‐Metabolic Overlap Among Patients With Acute Heart Failure: Insights From a Real‐World Multinational Cohort
Prognostic Impact of Cardiovascular‐Kidney‐Metabolic Overlap Among Patients With Acute Heart Failure: Insights From a Real‐World Multinational Cohort Open
Background The prognostic significance of cardiovascular‐kidney‐metabolic (CKM) multimorbidity in acute heart failure (AHF) remains unclear. We evaluated its association with clinical outcomes in a real‐world, multinational cohort of patie…
View article: A polygenic risk score improves the prediction of cardiovascular risk associated with obstructive sleep-apnea
A polygenic risk score improves the prediction of cardiovascular risk associated with obstructive sleep-apnea Open
Introduction Obstructive sleep apnea (OSA) carries increased cardiovascular (CV) risk. However, this risk is not fully captured by the apnea–hypopnea index (AHI). We investigated whether a validated coronary artery disease polygenic risk s…
View article: Familial and genetic relationships of major depressive disorders and adiposity markers in the community
Familial and genetic relationships of major depressive disorders and adiposity markers in the community Open
View article: Periodic limb movements during sleep, restless legs syndrome, and cognitive changes in older adults: a population-based longitudinal study
Periodic limb movements during sleep, restless legs syndrome, and cognitive changes in older adults: a population-based longitudinal study Open
Study Objectives To investigate the associations of periodic limb movements during sleep (PLMS) and restless legs syndrome (RLS) symptoms with longitudinal changes in cognitive performance among older adults. Methods We analyzed data from …
View article: Cohort Profile: Swiss Personalized Health Network Cohort Consortium
Cohort Profile: Swiss Personalized Health Network Cohort Consortium Open
Background Swiss cohort studies provide high-quality longitudinal data, but finding and comparing relevant studies across cohorts has historically been challenging. The Swiss Personalized Health Network Cohort Consortium (SPHN-CC) was esta…
View article: Association between BRINDA-corrected iron metabolism and lung function in the community: the CoLaus|PneumoLaus study
Association between BRINDA-corrected iron metabolism and lung function in the community: the CoLaus|PneumoLaus study Open
View article: Dietary caffeine to assess CYP1A2 activity, tailor clozapine doses, and predict treatment response: genetic, epigenetic and clinical analyses
Dietary caffeine to assess CYP1A2 activity, tailor clozapine doses, and predict treatment response: genetic, epigenetic and clinical analyses Open
Caffeine metabolic ratios (CMR) following monitored caffeine intake are the gold standard to probe cytochrome P450 (CYP) 1A2 activity, which metabolizes antipsychotics like clozapine and olanzapine. Given caffeine’s ubiquity, we tested whe…
View article: Impact of increased resident preparation time on internal medicine rounds in a tertiary teaching hospital: a time-motion study with a before-and-after comparison
Impact of increased resident preparation time on internal medicine rounds in a tertiary teaching hospital: a time-motion study with a before-and-after comparison Open
Objectives To determine whether postponing daily medical rounds to provide additional preparation time for residents reduces round duration and alters time allocation during rounds, with the hypothesis that increased preparation leads to m…
View article: Prediction of 10‐Year Fragility Fractures Using Muscle Health Indicators in Postmenopausal Women: The OsteoLaus Cohort
Prediction of 10‐Year Fragility Fractures Using Muscle Health Indicators in Postmenopausal Women: The OsteoLaus Cohort Open
Background Muscle strength, mass and function have been associated with falls, fractures and mortality, but the results vary between previous studies. We aimed to investigate the predictive ability of muscle strength and mass with 10‐year …
View article: Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids Open
View article: Associations between common genetic variants and income provide insights about the socio-economic health gradient
Associations between common genetic variants and income provide insights about the socio-economic health gradient Open
View article: Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus Cohort
Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus Cohort Open
STUDY AIMS: Sarcopenia is a progressive, age-related loss of muscle mass, strength and function. Given the ageing population and the adverse outcomes associated with sarcopenia, monitoring its epidemiology is particularly important. This s…
View article: Factor associated with and risk of cardiovascular disease in people with uncontrolled hypertension
Factor associated with and risk of cardiovascular disease in people with uncontrolled hypertension Open
We aimed to identify and validate factors related to uncontrolled hypertension. Participants treated with at least one antihypertensive drug from the prospective contemporaneous CoLaus|PsyCoLaus study were enrolled. We investigated the ass…
View article: Large-scale georeferenced neuroimaging and psychometry data link the urban environmental exposome with brain health
Large-scale georeferenced neuroimaging and psychometry data link the urban environmental exposome with brain health Open
View article: Impact of Different CKD Definitions on Long-Term Renal Function and Mortality in a Population-Based Cohort Study
Impact of Different CKD Definitions on Long-Term Renal Function and Mortality in a Population-Based Cohort Study Open
View article: EBNA-1 and VCA-p18 immunoglobulin markers link Epstein-Barr virus immune response and brain’s myelin content to fatigue in a community-dwelling cohort
EBNA-1 and VCA-p18 immunoglobulin markers link Epstein-Barr virus immune response and brain’s myelin content to fatigue in a community-dwelling cohort Open
View article: Prevalence of actionable pharmacogenetic variants and high‐risk drug prescriptions: A Swiss hospital‐based cohort study
Prevalence of actionable pharmacogenetic variants and high‐risk drug prescriptions: A Swiss hospital‐based cohort study Open
Drug type and dosing recommendation have been designed and optimized based on average response in the general population. Yet, there is significant inter‐individual variability in drug response, which results in treatment inefficacy or adv…
View article: Correlates of chronic pain onset and recovery in the <scp>CoLaus</scp> cohort
Correlates of chronic pain onset and recovery in the <span>CoLaus</span> cohort Open
Background Only few previous cohort studies examined simultaneously predictors of chronic pain (CP) onset and recovery. Furthermore, these studies used various sociodemographic and pain‐related characteristics, without standardized measure…
View article: Integrative Modeling of Accelerometry-Derived Sleep, Physical Activity, and Circadian Rhythm Domains With Current or Remitted Major Depression
Integrative Modeling of Accelerometry-Derived Sleep, Physical Activity, and Circadian Rhythm Domains With Current or Remitted Major Depression Open
Importance Accelerometry has been increasingly used as an objective index of sleep, physical activity, and circadian rhythms in people with mood disorders. However, most prior research has focused on sleep or physical activity alone withou…
View article: Sleep disturbances and incident risk of major depressive disorder in a population-based cohort
Sleep disturbances and incident risk of major depressive disorder in a population-based cohort Open
View article: Self-reported caffeine consumption miss-matched consumption measured by plasma levels of caffeine and its metabolites: results from two population-based studies
Self-reported caffeine consumption miss-matched consumption measured by plasma levels of caffeine and its metabolites: results from two population-based studies Open
Importance and objective Self-reported caffeine consumption has been widely used in research while it may be subject to bias. We sought to investigate the associations between self-reported caffeine consumption and plasma levels of caffein…
View article: Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits Open
View article: Adherence to 2020 ESC recommendations on physical activity in a population with different cardiovascular risk levels: A prospective population-based study from the CoLaus/PsyCoLaus study
Adherence to 2020 ESC recommendations on physical activity in a population with different cardiovascular risk levels: A prospective population-based study from the CoLaus/PsyCoLaus study Open
View article: The neurobiology of life course socioeconomic conditions and associated cognitive performance in middle to late adulthood
The neurobiology of life course socioeconomic conditions and associated cognitive performance in middle to late adulthood Open
Despite major advances, our understanding of the neurobiology of life course socioeconomic conditions is still scarce. This study aimed to provide insight into the pathways linking socioeconomic exposures – household income, last-known occ…
View article: Lateral medullary vascular compression manifesting as paroxysmal hypertension
Lateral medullary vascular compression manifesting as paroxysmal hypertension Open
View article: Spatial analysis of 10-year predicted risk and incident atherosclerotic cardiovascular disease: the CoLaus cohort
Spatial analysis of 10-year predicted risk and incident atherosclerotic cardiovascular disease: the CoLaus cohort Open
View article: NFAT5 and SLC4A10 loci associate with plasma osmolality
NFAT5 and SLC4A10 loci associate with plasma osmolality Open
Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide association study me…
View article: Blood pressure status, trajectories and cardiovascular disease: the CoLaus|PsyCoLaus prospective study
Blood pressure status, trajectories and cardiovascular disease: the CoLaus|PsyCoLaus prospective study Open
Background High blood pressure (BP) is a major risk factor for cardiovascular disease (CVD). Adequate treatment of high BP should reduce the risk of CVD, but this association has seldom been assessed in a general population setting. Method…
View article: Effect of dairy consumption on cognition in older adults: A population-based cohort study
Effect of dairy consumption on cognition in older adults: A population-based cohort study Open
View article: Associations between common genetic variants and income provide insights about the socioeconomic health gradient
Associations between common genetic variants and income provide insights about the socioeconomic health gradient Open
We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient (N=668,288). We found 162 genomic loci associated with a common…