Explanipedia

Classifying hypopneas as obstructive or central can enhance transvenous phrenic nerve stimulation therapy patient selection and outcomes Open

Kara Dupuy-McCauley, Alan R. Schwartz, Shahrokh Javaheri, Robin Germany, Scott McKane , et al. · 2025

Registry: ClinicalTrials.gov; Identifier: NCT01816776.

Ascending and Descending Pharyngeal Opening Pressures During Drug‐Induced Sleep Endoscopy: Mechanistic Insights for Sleep Surgeons Open

Linda C. Magaña, Tice R. Harkins, Yatika Dixit, Andrew Wiemken, Brendan T Keenan , et al. · 2025

Objective To assess whether differences exist between ascending pharyngeal opening pressure (PhOP A ) and descending pharyngeal opening pressure (PhOP D ) obtained from positive airway pressure (PAP) titrations during drug‐induced sleep en…

1509 Sleep and Exercise as Exacerbators of Hypoxemia and Their Responses to Supplemental Oxygen at High Altitude Open

Cristian Zhang, Alan R. Schwartz, William Checkley, Luu V. Pham · 2025

Introduction Acute mountain sickness, a potentially life-threatening condition consisting of sleep disturbances, headache, cerebral edema and pulmonary edema, is a complication of travel to high altitude. These complications stem from hypo…

0761 Detailed Three-Year Effects of Proximal Targeted Hypoglossal Nerve Stimulation on Apnea-Hypopnea Index in Moderate to Severe Obstructive Sleep Apnea Open

Alan R. Schwartz, Ofer Jacobowitz, Samuel Mickelson, Mitchell D. Miller, Arie Oliven , et al. · 2025

Introduction Proximal hypoglossal nerve stimulation (pHGNS) has been shown in the THN3 randomized, controlled trial to produce durable three-year improvements in quality of life, oxygenation, and sleep-disordered breathing (Apnea-Hypopnea …

0718 Effects of Proximal Targeted Hypoglossal Nerve Stimulation on Apnea-Hypopnea Index in Moderate to Severe OSA: OSPREY Randomized Controlled Trial Open

Atul Malhotra, Alan R. Schwartz, Richard Bogan, Shaun A. Nguyen, Samuel Mickelson , et al. · 2025

Introduction Clinically significant improvement of the total Apnea-hypopnea index (AHI) in the OSPREY randomized, controlled trial (RCT) of proximal hypoglossal nerve stimulation (pHGNS) was demonstrated for patients receiving active treat…

0614 Metabolic Effects of Acute Sustained Hypoxia in Healthy Volunteers Open

Luu Pham, Alan R. Schwartz, Daisy Duan, Vsevolod Y. Polotsky, Jonathan C. Jun · 2025

Introduction Obstructive sleep apnea (OSA) causes recurrent periods of hypoxia during sleep and is associated with disorders of glucose homeostasis including glucose intolerance and diabetes. In OSA patients, CPAP withdrawal increased gluc…

0723 Hypopnea Classification Impact on Transvenous Phrenic Nerve Stimulation Therapy Patient Selection and Efficacy Open

Kara Dupuy-McCauley, Alan R. Schwartz, Shahrokh Javaheri, Robin Germany, Scott McKane , et al. · 2025

Introduction Despite AASM scoring guidelines encouraging classifying hypopneas as central or obstructive, classification is underutilized in practice. However, without that effort patients may receive an incorrect primary diagnosis and sub…

Role of Glossopharyngeal Nerve Stimulation in Stabilizing the Lateral Pharyngeal Wall and Ventilation in OSA Open

David T. Kent, John Ceremsak, Yike Li, Pratyusha Yalamanchi, Kyle Mannion , et al. · 2025

Flow Profiles Identify Sources of Poor Metered Dose Inhaler Technique Open

Stuart D. King, Rohan D. Milak, Hartmut Schneider, Mudiaga Sowho, Elizabeth C. Katz , et al. · 2024

Background: Inhaled medications are commonly used as therapy for obstructive lung disease (OLD); however, poor technique from pressurized metered dose inhalers (pMDIs) can severely limit drug delivery and therapeutic efficacy. A novel flow…

Ansa cervicalis stimulation effects on upper airway patency: a structure-based analysis Open

Yike Li, Alan R. Schwartz, David L. Zealear, Matthew S. Shotwell, Megan E. Hall , et al. · 2024

Rationale Ansa cervicalis stimulation (ACS) of the infrahyoid muscles has been proposed as a neurostimulation therapy for obstructive sleep apnoea (OSA). ACS stabilises the pharynx by pulling it caudally, but its specific effects on flow l…

Multidimensional phenotyping to distinguish among central (CSA), obstructive (OSA) and co-existing central and obstructive sleep apnea (CSA-OSA) phenotypes in real-world data Open

Jean‐Louis Pépin, Alan R. Schwartz, Rami Khayat, Robin Germany, Scott McKane , et al. · 2024

Our findings imply that not differentiating between central and obstructive hypopneas will underestimate the severity of central sleep disordered breathing abnormalities that mislead therapeutic decisions and might limit improvements in qu…

Physiologic and anatomic determinants of hyoid motion during drug-induced sleep endoscopy Open

Manan H. Parekh, Eric Thuler, Vasiliki Triantafillou, Everett G. Seay, Chandra M. Sehgal , et al. · 2024

Purpose To examine factors accounting for differences in hyoid motion during obstructive breathing events amongst obstructive sleep apnea (OSA) patients. Methods This was a prospective cohort study from June 2022 to October 2022. Patients …

The Whimsical Nature of Airway Obstruction during Drug‐Induced Sleep Endoscopy Open

Tice R. Harkins, Vasiliki Triantafillou, Everett G. Seay, Alan R. Schwartz, Raj C. Dedhia · 2024

A 47‐year‐old male patient diagnosed with severe obstructive sleep apnea (OSA) sought alternatives to positive airway pressure, prompting evaluation with drug‐induced sleep endoscopy (DISE). He underwent a specialized DISE with nasal airfl…

Association Between Soft Tissue Measures From Computed Tomography and Upper Airway Collapsibility on Drug‐Induced Sleep Endoscopy Open

Eric Thuler, Manan H. Parekh, Jules G. Rodin, Everett G. Seay, Andrew Wiemken , et al. · 2024

Objective Positive airway pressure (PAP) titration during drug‐induced sleep endoscopy (DISE) provides objective measures of upper airway collapsibility. While skeletal measurements relate to collapsibility measures on DISE, the influence …

The Prevalence of Sentinel Central Events (SCent) During Drug‐Induced Sleep Endoscopy Open

Julianna Rodin, Manan H. Parekh, Yi Cai, Brendan T Keenan, Eric Thuler , et al. · 2024

Objective With the recent addition of airflow and respiratory effort channels, our group has observed central and mixed apnea events during drug‐induced sleep endoscopy (DISE). We measured the frequency and timing of sentinel central and/o…

Effects of Negative Pressure Ventilation on Lung Volume and Airflow in Drug-Induced Sleep Endoscopy Open

Jason L. Yu, Jack Plageman, Katherine P. Gouldman, Donald L. Bliwise, Alan R. Schwartz · 2023

Airway Collapsibility during Drug‐Induced Sleep Endoscopy Relates with Clinical Features of Obstructive Sleep Apnea Open

Manan H. Parekh, Vasiliki Triantafillou, Brendan T Keenan, Everett G. Seay, Eric Thuler , et al. · 2023

Introduction Increased pharyngeal collapsibility leads to obstructive sleep apnea (OSA). Positive airway pressure titration during drug‐induced sleep endoscopy (DISE‐PAP) provides objective collapsibility metrics, the pharyngeal opening pr…

Atomoxetine and spironolactone combine to reduce obstructive sleep apnea (OSA) severity and blood pressure (BP) in hypertensive patients. Open

Alan R. Schwartz, Laura Herpel, Richard Bogan, Bruce Corser · 2023

Background: Norepinephrine reuptake inhibitors such as atomoxetine (ato) can improve OSA by increasing pharyngeal muscle activity. Mineralocorticoid antagonists such as spironolactone, may potentiate the reduction of OSA severity. W…

The Application of Ultrasound to Quantify Hyoid Motion During Drug‐Induced Sleep Endoscopy Open

Manan H. Parekh, Eric Thuler, Vasiliki Triantafillou, Everett G. Seay, Chandra M. Sehgal , et al. · 2023

Introduction The significance of hyoid dynamics in OSA pathophysiology remains unclear. Drug‐induced sleep endoscopy (DISE) is often used for evaluating patients intolerant to positive airway pressure (PAP) therapy. We performed DISE with …

0444 Racial Differences in Positive Airway Pressure Requirements Amongst Obstructive Sleep Apnea Patients (The RACE-PAP Study) Open

Yi Cai, Manan Parekh, Julianna Rodin, Akshay Tangutur, Jason L. Yu , et al. · 2023

Introduction Prior studies of patients with obstructive sleep apnea (OSA) show racial differences in clinical presentation. When compared with White patients, Black patients present with more severe OSA and greater sleepiness. Racial diffe…

0453 3-Year Outcomes of Proximal Hypoglossal Nerve Stimulation in the THN3 Controlled Trial Open

Alan R. Schwartz, Ofer Jacobowitz, Samuel Mickelson, Mitchell D. Miller, Arie Oliven , et al. · 2023

Introduction The THN3 randomized, controlled trial of moderate to severe obstructive sleep apnea (OSA) showed that proximal (“targeted”) hypoglossal nerve stimulation (HGNS) safely improved sleep-disordered breathing (SDB) and quality of l…

0427 Airway Pressures Define Collapsibility of Specific Pharyngeal Sites of Obstruction during Drug-induced Sleep Endoscopy Open

Akshay Tangutur, Everett G. Seay, Eric Thuler, Manan Parekh, Raj C. Dedhia , et al. · 2023

Introduction Obstructive sleep apnea (OSA) is characterized by repetitive episodes of pharyngeal obstruction at one or more collapse sites. Multilevel collapse is a negative predictive factor for PAP-alternative surgical treatments. Pharyn…

0487 The effect of negative pressure ventilation on airflow in obstructive sleep apnea subjects undergoing drug induced sleep endoscopy Open

Jason L. Yu, Jack Plageman, Alan R. Schwartz · 2023

Introduction Drug induced sleep endoscopy (DISE) is used to visually characterize pharyngeal airway collapse in obstructive sleep apnea (OSA) to help determine appropriate patients for OSA surgery. The procedure has grown in complexity wit…

Targeted Hypoglossal Nerve Stimulation for Patients With Obstructive Sleep Apnea Open

Alan R. Schwartz, Ofer Jacobowitz, David W. Eisele, Samuel A. Mickelson, Mitchell B. Miller , et al. · 2023

Importance Evidence is lacking from randomized clinical trials of hypoglossal nerve stimulation in obstructive sleep apnea (OSA). Objective To evaluate the safety and effectiveness of targeted hypoglossal nerve stimulation (THN) of the pro…

Changes in tongue morphology predict responses in pharyngeal patency to selective hypoglossal nerve stimulation Open

Thomaz Fleury Curado, Luu V. Pham, Tamás Ötvös, Tracy Klopfer, Carla Freire , et al. · 2023

Fleury Curado T, Pham L, Otvos T, et al. Changes in tongue morphology predict responses in pharyngeal patency to selective hypoglossal nerve stimulation. J Clin Sleep Med. 2023;19(5):947-955.

Distinguishing central from obstructive hypopneas on a clinical polysomnogram Open

Shahrokh Javaheri, David M. Rapoport, Alan R. Schwartz · 2023

Javaheri S, Rapoport DM, Schwartz AR. Distinguishing central from obstructive hypopneas on a clinical polysomnogram. J Clin Sleep Med. 2023;19(4):823-834.

Quantitative Effects of Ansa Cervicalis Stimulation in Obstructive Sleep Apnea Open

Yike Li, Kelsey Richard, Alan R. Schwartz, David L. Zealear, Christopher J. Lindsell , et al. · 2023

Enhanced <span>drug‐induced</span> sleep endoscopy: Distinguishing central from obstructive apnea Open

Crystal Cheong, Raj C. Dedhia, Everett G. Seay, Sebastian M. Jara, Jorge Mora , et al. · 2022

This case report describes a patient originally diagnosed with obstructive sleep apnea (OSA) who was later found to have central sleep apnea (CSA) during drug-induced sleep endoscopy, which was subsequently confirmed on an in-laboratory sl…

The Accuracy and Reliability of Visually Assessed Pharyngeal Opening Pressures During Drug‐Induced Sleep Endoscopy Open

Jason L. Yu, Eric Thuler, Everett G. Seay, Alan R. Schwartz, Raj C. Dedhia · 2022

Objective To examine the accuracy and interrater reliability of a visually assessed vs airflow‐based measure of pharyngeal collapsibility obtained in patients with obstructive sleep apnea undergoing drug‐induced sleep endoscopy (DISE). Stu…

0765 Enhanced Response to Targeted Hypoglossal Nerve Stimulation in Patients with Normal Sleep Efficiency: A THN3 Post-Hoc Analysis Open

Alan R. Schwartz, Ofer Jacobowitz, Samuel Mickelson, Mitchell D. Miller, Arie Oliven , et al. · 2022

Introduction THN3 was the first reported parallel-arm, randomized controlled trial of hypoglossal nerve stimulation (HGNS), wherein targeted HGNS (THN) was shown to be safe and efficacious at ameliorating sleep disordered breathing in sele…

Alan R. Schwartz YOU? Author Swipe