Alan Race
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View article: Use of metabolic imaging to monitor heterogeneity of tumour response following therapeutic mTORC1/2 pathway inhibition
Use of metabolic imaging to monitor heterogeneity of tumour response following therapeutic mTORC1/2 pathway inhibition Open
The PI3K–mTOR–AKT pathway regulates tumour proliferation, gene expression and metabolism, but pathway inhibition induces heterogeneous feedback reactivation, limiting anti-tumour responses. Measuring heterogeneity of pathway inhibition in …
View article: List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta Open
Cancer Research UK Rosetta Grand Challenge consortium list of members
View article: List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta Open
Cancer Research UK Rosetta Grand Challenge consortium list of members
View article: Data from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
Data from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta Open
Summary:Understanding tumor heterogeneity is a major challenge that was recognized as one of the first Cancer Grand Challenges, with a call to provide solutions to visualize tumor heterogeneity. The Rosetta team took on this challenge, exp…
View article: Pushing the limits of cell segmentation models for imaging mass cytometry
Pushing the limits of cell segmentation models for imaging mass cytometry Open
Imaging mass cytometry (IMC) is a relatively new technique for imaging biological tissue at subcellular resolution. In recent years, learning-based segmentation methods have enabled precise quantification of cell type and morphology, but t…
View article: Visualization and data exploration of chromosome conformation capture data using Voronoi diagrams with v3c-viz
Visualization and data exploration of chromosome conformation capture data using Voronoi diagrams with v3c-viz Open
Chromosome conformation capture (3C) sequencing approaches, like Hi-C or micro-C, allow for an unbiased view of chromatin interactions. Most analysis methods rely on so-called interaction matrices, which are derived from counting read pair…
View article: v3c-viz: Visualization and data exploration of chromosome conformation capture data at full resolution using Voronoi diagrams
v3c-viz: Visualization and data exploration of chromosome conformation capture data at full resolution using Voronoi diagrams Open
Chromosome conformation capture (3C) sequencing approaches, like Hi-C or micro-C, allow for an unbiased view of chromatin interactions. Most analysis methods rely on so-called interaction matrices, which are derived from counting read pair…
View article: MALDI mass spectrometry imaging: From constituents in fresh food to ingredients, contaminants and additives in processed food
MALDI mass spectrometry imaging: From constituents in fresh food to ingredients, contaminants and additives in processed food Open
Mass Spectrometry imaging (MS imaging) provides spatial information for a wide range of compound classes in different sample matrices. We used MS imaging to investigate the distribution of components in fresh and processed food, including …
View article: Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution
Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution Open
Gaining insight into the heterogeneity of nanoparticle drug distribution within tumors would improve
\nboth design and clinical translation of nanomedicines. There is little data showing the spatio-temporal
\nbehavior of nanomedicines in t…
View article: MALDI mass spectrometry imaging of fresh and processed food: constituents, ingredients, contaminants and additives
MALDI mass spectrometry imaging of fresh and processed food: constituents, ingredients, contaminants and additives Open
Mass Spectrometry imaging (MS imaging) provides spatial information for a wide range of compound classes in different sample matrices. We used MS imaging to investigate the distribution of components in fresh and processed food, including …
View article: Holistic Characterization of a <i>Salmonella</i> Typhimurium Infection Model Using Integrated Molecular Imaging
Holistic Characterization of a <i>Salmonella</i> Typhimurium Infection Model Using Integrated Molecular Imaging Open
A more complete and holistic view on host-microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, w…
View article: Book Reviews
Book Reviews Open
Jione Havea's edited volume Religion and Power is the first in a five-volume series on Theology in the Age of Empire, it offers essential insights in to the matrix of power and religion.The book explores the complexities of power structure…
View article: Religions in Dialogue: From Theocracy to Democracy
Religions in Dialogue: From Theocracy to Democracy Open
Part 1 Setting the dialogical scene: Introduction - Why democracy and why three religions?, Alan Race and Ingrid Shafer Commendation - Religion, common values and dialogue, El Hassan bin Talal The dynamics of dialogue between Jews, Christi…
View article: Two-Phase and Graph-Based Clustering Methods for Accurate and Efficient Segmentation of Large Mass Spectrometry Images
Two-Phase and Graph-Based Clustering Methods for Accurate and Efficient Segmentation of Large Mass Spectrometry Images Open
Clustering is widely used in MSI to segment anatomical features and differentiate tissue types, but existing approaches are both CPU and memory-intensive, limiting their application to small, single data sets. We propose a new approach tha…
View article: Raster-Mode Continuous-Flow Liquid Microjunction Mass Spectrometry Imaging of Proteins in Thin Tissue Sections
Raster-Mode Continuous-Flow Liquid Microjunction Mass Spectrometry Imaging of Proteins in Thin Tissue Sections Open
Mass spectrometry imaging by use of continuous-flow liquid microjunction sampling at discrete locations (array mode) has previously been demonstrated. In this Letter, we demonstrate continuous-flow liquid microjunction mass spectrometry im…
View article: Testing for Multivariate Normality in Mass Spectrometry Imaging Data: A Robust Statistical Approach for Clustering Evaluation and the Generation of Synthetic Mass Spectrometry Imaging Data Sets
Testing for Multivariate Normality in Mass Spectrometry Imaging Data: A Robust Statistical Approach for Clustering Evaluation and the Generation of Synthetic Mass Spectrometry Imaging Data Sets Open
Spatial clustering is a powerful tool in mass spectrometry imaging (MSI) and has been demonstrated to be capable of differentiating tumor types, visualizing intratumor heterogeneity, and segmenting anatomical structures. Several clustering…
View article: SpectralAnalysis: Software for the Masses
SpectralAnalysis: Software for the Masses Open
The amount of data produced by spectral imaging techniques, such as mass spectrometry imaging, is rapidly increasing as technology and instrumentation advances. This, combined with an increasingly multimodal approach to analytical science,…
View article: MALDI Imaging of Liquid Extraction Surface Analysis Sampled Tissue
MALDI Imaging of Liquid Extraction Surface Analysis Sampled Tissue Open
Combined mass spectrometry imaging methods in which two different techniques are executed on the same sample have recently been reported for a number of sample types. Such an approach can be used to examine the sampling effects of the firs…
View article: LESA FAIMS Mass Spectrometry for the Spatial Profiling of Proteins from Tissue
LESA FAIMS Mass Spectrometry for the Spatial Profiling of Proteins from Tissue Open
We have shown previously that coupling of high field asymmetric waveform ion mobility spectrometry (FAIMS), also known as differential ion mobility, with liquid extraction surface analysis (LESA) mass spectrometry of tissue results in sign…
View article: Analysis of urine, oral fluid and fingerprints by liquid extraction surface analysis coupled to high resolution MS and MS/MS – opportunities for forensic and biomedical science
Analysis of urine, oral fluid and fingerprints by liquid extraction surface analysis coupled to high resolution MS and MS/MS – opportunities for forensic and biomedical science Open
Liquid Extraction Surface Analysis (LESA) is a new, high throughput tool for ambient mass spectrometry.
View article: Liquid Extraction Surface Analysis Mass Spectrometry Coupled with Field Asymmetric Waveform Ion Mobility Spectrometry for Analysis of Intact Proteins from Biological Substrates
Liquid Extraction Surface Analysis Mass Spectrometry Coupled with Field Asymmetric Waveform Ion Mobility Spectrometry for Analysis of Intact Proteins from Biological Substrates Open
Previously we have shown that liquid extraction surface analysis (LESA) mass spectrometry is suitable for the analysis of intact proteins from a range of biological substrates. Here we show that LESA mass spectrometry may be coupled with h…