Explanipedia

277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion Open

Sydnye L. Shuttleworth, Michael Bauer, Jessica L Kelliher, Aaron J. Storey, Nicole E. Scharping , et al. · 2025

685 EZH2 inhibition impairs CD8+ CAR-T cell persistence Open

Daniel Fil, Megan R. Reed, Katherine Wallis, Billie Heflin, Sydnye L. Shuttleworth , et al. · 2025

Epigenetic priming promotes tyrosine kinase inhibitor resistance and oncogene amplification Open

Rebecca M. Starble, Eric G. Sun, Rana Gbyli, Jonathan S. D. Radda, Jiuwei Lu , et al. · 2025

In mammalian cells, gene copy number is controlled to maintain gene expression and genome stability. However, a common molecular feature across cancer types is oncogene amplification, increasing the copy number and expression of tumor-prom…

Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG Open

Meenakshi Upreti, Astgik Petrosyan, Matthew E. Thornton, Anahit Hovsepyan, G. Esteban Fernández , et al. · 2025

It has become evident from decades of clinical trials that multimodal therapeutic approaches with focus on cell intrinsic and microenvironmental cues are needed to improve understanding and treat the rare, inoperable, and ultimately fatal …

YY1 relieves p300 autoinhibition to promote histone acetylation in advanced prostate cancer, enhancing the oncogenic signaling of Androgen Receptor Splice Variant 7 Open

Chenxi Xu, Dongyu Wu, Bo Pan, Xiaoxiao Ren, Samuel G. Mackintosh , et al. · 2025

Genetic and epigenetic aberrations often act in concert to establish oncogenic transcriptomic programs in aggressive cancers. For example, the development of castration-resistant prostate cancer (CRPC), an advanced prostate cancer form, is…

BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication Open

Dongxu Li, Zhimin Zhang, Mei Liu, Yu Yao, Yiran Guo , et al. · 2025

Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model Open

Alicja Urbaniak, Billie Heflin, Eric R. Siegel, Megan R. Reed, J. Stephen Nix , et al. · 2025

Monensin ( MON ) is a polyether ionophore antibiotic of natural origin and is an FDA-approved drug for veterinary use. Recent studies have highlighted its potential anti-cancer activity in various in vitro and in vivo models. In this study…

BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication Open

Dongxu Li, Zhimin Zhang, Mei Liu, Yu Yao, Yiran Guo , et al. · 2025

Mono-methylation of histone H4 lysine 20 (H4K20me1) regulates DNA replication, cell cycle progression and DNA damage repair. How exactly H4K20me1 regulates these biological processes remains unclear. Here, we report that an evolutionarily …

EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma Open

Jacob L. Edmondson, Megan R. Reed, Daniel Fil, Billie Heflin, Alyson T. McKinnon , et al. · 2025

Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction Open

Isabelle R. Miousse, Oscar Zuniga, Sarita Garg, Lokesh Akana, Henrique Rodrigues , et al. · 2025

Purpose Approximately one-third of colorectal cancer cases involve the rectum, where radiation therapy is an integral part of the treatment of this disease. However, KRAS mutations are associated with poor clinical outcomes and lower thera…

474 Repositioning monensin: Enhancing anti-cancer activity and immune modulation in breast cancer cells Open

Alicja Urbaniak, Eric R. Siegel, Marta Jędrzejczyk, Greta Klejborowska, Natalia Stępczyńska , et al. · 2025

Objectives/Goals: Monensin is FDA approved for use in veterinary medicine. Recent studies pointed to its potent anticancer activity. Since de novo drug discovery process typically takes 10 to 15 years and requires an investment of approxim…

Staphylococcus aureus Proteins Implicated in the Reduced Virulence of sarA and sarA/agr Mutants in Osteomyelitis Open

Karen E. Beenken, Mara J. Campbell, Stephanie D. Byrum, Rick D. Edmondson, Samuel G. Mackintosh , et al. · 2025

Using a murine osteomyelitis model, we recently demonstrated that Staphylococcus aureus sarA and sarA/agr mutants generated in the USA300 strain LAC are attenuated to a greater extent than an isogenic agr mutant and that this can be attrib…

Dynamic global acetylation remodeling during the yeast heat shock response Open

Rebecca E. Hardman-Kavanaugh, Aaron J. Storey, Tara Stuecker, Stephanie E. Hood, Gregory A. Barrett‐Wilt , et al. · 2025

All organisms experience stress and must rapidly respond to changing conditions. Thus, cells have evolved sophisticated rapid-response mechanisms such as post-translational protein modification to rapidly and reversibly modulate protein ac…

Correction: Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors Open

Sanjay Adhikary, Subrata Roy, Shailesh Budhathoki, S. Chowdhury, Amanda Stillwell , et al. · 2025

Correction for ‘Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors’ by Sanjay Adhikary et al. , RSC Med. Chem. , 2025, 16 , 1105–1130, https://doi.org/10.1039/d4m…

Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion Open

Sydnye L. Shuttleworth, Monika Bauer, Jessica L Kelliher, Aaron J. Storey, Nicole E. Scharping , et al. · 2025

Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors Open

Sanjay Adhikary, Subrata Roy, Shailesh Budhathoki, S. Chowdhury, Amanda Stillwell , et al. · 2024

Several fused-thiazole derivatives have been studied for antimelanoma properties. Lead compounds are effective tumor growth inhibitors in mice, which are potent β- and γ-actin cytoskeleton inhibitors with a probable mechanism of β-PARVIN i…

538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response Open

Jacob L Edmondson, Megan R. Reed, Daniel Fil, Billie Heflin, Nathan L. Avaritt , et al. · 2024

1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells Open

Megan R. Reed, Daniel Fil, Billie Heflin, Jacob L Edmondson, Brian Koss , et al. · 2024

319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion Open

Sydnye L. Shuttleworth, Michael Bauer, Jessica L Kelliher, Aaron J. Storey, Jacob L Edmondson , et al. · 2024

TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons Open

Shuai Zhao, Jiuwei Lu, Bo Pan, Huitao Fan, Stephanie D. Byrum , et al. · 2024

383 Beyond Antibiotics: Monensin and its Derivatives as Promising Anti-Breast Cancer Agents Open

Alicja Urbaniak, Marta Jędrzejczyk, Greta Klejborowska, Natalia Stępczyńska, Adam Huczyński , et al. · 2024

OBJECTIVES/GOALS: Although the approval of immune checkpoint inhibitors (ICIs) revolutionized the treatment of metastatic breast cancer (BC), yet about 30% remain unresponsive. Since the potency of ICIs depends on the efficient presentatio…

Synthesis and Anti‐Melanoma Activity of Acryloyl Pyridinone Analogues Open

Alicja Urbaniak, Chandramohan Bathula, Jyoti Chauhan, Prateek Rai, Joshua Thammathong , et al. · 2023

A major challenge for clinical management of melanoma is the prevention and treatment of metastatic disease. Drug discovery efforts over the last 10 years have resulted in several drugs that improve the prognosis of metastatic melanoma; ho…

TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons Open

Shuai Zhao, Jiuwei Lu, Bo Pan, Huitao Fan, Stephanie D. Byrum , et al. · 2023

Trimethylation of histone H3 lysine 9 (H3K9me3) is crucial for the regulation of gene repression and heterochromatin formation, cell-fate determination and organismal development¹. H3K9me3 also provides an essential mechanism fo…

536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma Open

Jacob L Edmondson, Megan R. Reed, Daniel Fil, Billie Heflin, Alan J. Tackett , et al. · 2023

Background Unleashing the immune anti-tumor response through immune checkpoint blockade (ICB) therapy has been successful in combating solid-tumor malignancies, including metastatic melanoma. When successful, the anti-tumor response is pot…

304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors Open

Sydnye L. Shuttleworth, Aaron J. Storey, Michael Bauer, Jessica L Kelliher, Lora J. Rogers , et al. · 2023

Background Adoptive T cell therapies are widely considered to be the next frontier in cancer immunotherapy treatment but are currently only effective at treating cancers that do not form solid tumors. Tumor-infiltrating lymphocytes (TILs) …

Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma Open

Lauren C. Morehead, Brian Koss, Daniel Fil, Billie Heflin, Sarita Garg , et al. · 2023

Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model Open

Lauren C. Morehead, Sarita Garg, Katherine Wallis, Camila Simões, Eric R. Siegel , et al. · 2023

Dietary methionine restriction (MR), defined as a reduction of methionine intake by around 80%, has been shown to reproducibly decrease tumor growth and synergize with cancer therapies. In this study, we combined DMR with immune checkpoint…

Characterization of methionine dependence in melanoma cells Open

Sarita Garg, Lauren C. Morehead, Jordan T. Bird, Stefan Graw, Allen Gies , et al. · 2023

Dietary methionine restriction is associated with a reduction in tumor growth in preclinical studies and an increase in lifespan in animal models.

Monensin and its Derivatives Exhibit Anti-Melanoma Activity In Vitro Open

Alicja Urbaniak, Marta Jędrzejczyk, Greta Klejborowska, Natalia Stępczyńska, Adam Huczyński , et al. · 2023

Oncogenic signaling-mediated regulation of chromatin during tumorigenesis Open

Jahangir Alam, Md Nazmul Huda, Alan J. Tackett, Sayem Miah · 2023

Alan J. Tackett YOU? Author Swipe