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View article: Obstetrical use of intravenous immunoglobulin: A single-centre retrospective study
Obstetrical use of intravenous immunoglobulin: A single-centre retrospective study Open
Findings highlight the need for optimized intravenous immunoglobulin use in obstetrics and future research to ensure safety, efficacy, and evidence-based guidance in clinical practice and policy.
View article: A hospital policy of tranexamic acid to reduce transfusion in major non-cardiac surgery: The traction trial
A hospital policy of tranexamic acid to reduce transfusion in major non-cardiac surgery: The traction trial Open
BACKGROUND Whether a hospital policy of tranexamic acid administration for patients undergoing major noncardiac surgery safely reduces red blood cell (RBC) transfusion without increasing thrombotic risk is uncertain. METHODS We conducted a…
View article: Neuraxial analgesia in pregnant individuals with bleeding disorders: a retrospective descriptive study of obstetric anesthesia practices and outcomes
Neuraxial analgesia in pregnant individuals with bleeding disorders: a retrospective descriptive study of obstetric anesthesia practices and outcomes Open
With multidisciplinary planning and evidence-aligned laboratory targets, neuraxial analgesia was offered safely to most pregnant individuals with bleeding disorders within our cohort. Larger multicenter studies and registry initiatives are…
View article: Predictors of platelet count response following intravenous immunoglobulin use for maternal thrombocytopenia
Predictors of platelet count response following intravenous immunoglobulin use for maternal thrombocytopenia Open
IVIG effectively increases PLT counts in pregnant persons with severe thrombocytopenia, especially in those with a nadir PLT < 30 × 109/L, IPF < 16 %, or pre-IVIG PLT < 50 × 109/L. This study highlights the importance of careful patient se…
View article: Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery
Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery Open
Importance Excessive bleeding is a common and prognostically important complication of cardiac surgery. For bleeding related to coagulation factor deficiency, frozen plasma is the most used therapy. Preliminary trials indicate that 4-facto…
View article: Red blood cell utilization in patients with sickle cell disease: A Canadian single‐center experience
Red blood cell utilization in patients with sickle cell disease: A Canadian single‐center experience Open
Background Red blood cell (RBC) utilization in patients with sickle cell disease (SCD) in Canada is poorly defined. This study describes RBC utilization in an SCD cohort at a single Canadian center. Study Design and Methods All adults with…
View article: Privacy‐preserving federated data access and federated learning: Improved data sharing and <scp>AI</scp> model development in transfusion medicine
Privacy‐preserving federated data access and federated learning: Improved data sharing and <span>AI</span> model development in transfusion medicine Open
Background Health data comprise data from different aspects of healthcare including administrative, digital health, and research‐oriented data. Together, health data contribute to and inform healthcare operations, patient care, and researc…
View article: From Theory to Therapy: Evaluating Canadian Hemophilia Treatment Centres' Readiness for Gene Therapy Implementation
From Theory to Therapy: Evaluating Canadian Hemophilia Treatment Centres' Readiness for Gene Therapy Implementation Open
Introduction: Gene therapies (GT) present a transformative promise for persons with hemophilia, potentially offering a long-term solution to improve patient care and experiences. However, in publicly funded systems, GT's promise will fall …
View article: A global analysis of the use of immunoglobulin, shortages in supply, and mitigating measures: A survey of hospital providers (a <scp>BEST</scp> Collaborative study)
A global analysis of the use of immunoglobulin, shortages in supply, and mitigating measures: A survey of hospital providers (a <span>BEST</span> Collaborative study) Open
Background Immunoglobulin (IG) therapy is widely used to treat primary and secondary immune deficiencies and as immunomodulatory agent for various disorders. There is great concern that shortages of IG may rise, potentially affecting medic…
View article: How do we achieve blinding in modern electronic and paper medical records during the conduct of transfusion trials?
How do we achieve blinding in modern electronic and paper medical records during the conduct of transfusion trials? Open
Background Regulatory aspects of transfusion medicine add complexity in blinded transfusion trials when considering various electronic record keeping software and blood administration processes. The aim of this study is to explore strategi…
View article: Intraoperative Blood Management Strategies for Patients Undergoing Noncardiac Surgery
Intraoperative Blood Management Strategies for Patients Undergoing Noncardiac Surgery Open
Importance There is marked variability in red blood cell (RBC) transfusion during the intraoperative period. The development and implementation of existing clinical practice guidelines have been ineffective in reducing this variability. Ob…
View article: Management strategies in persons with inherited haemophilia requiring antithrombotic therapy: A scoping review
Management strategies in persons with inherited haemophilia requiring antithrombotic therapy: A scoping review Open
Background Thromboembolic events are increasingly reported in the aging haemophilia population. The purpose of this study was to understand current practices and identify knowledge and research gaps in the management of persons with haemop…
View article: Point-of-care haemoglobin accuracy and transfusion outcomes in non-cardiac surgery at a Canadian tertiary academic hospital: protocol for the PREMISE observational study
Point-of-care haemoglobin accuracy and transfusion outcomes in non-cardiac surgery at a Canadian tertiary academic hospital: protocol for the PREMISE observational study Open
Introduction Transfusions in surgery can be life-saving interventions, but inappropriate transfusions may lack clinical benefit and cause harm. Transfusion decision-making in surgery is complex and frequently informed by haemoglobin (Hgb) …
View article: Neuraxial Analgesia in Pregnant Individuals with Bleeding Disorders: A Comprehensive Examination of Obstetric Anesthesia Practices and Outcomes
Neuraxial Analgesia in Pregnant Individuals with Bleeding Disorders: A Comprehensive Examination of Obstetric Anesthesia Practices and Outcomes Open
Introduction: Neuraxial analgesia in obstetric anesthesia offers multiple advantages when compared with general anesthesia, including better pain relief and patient satisfaction, reduced opioid-related side effects, and decreased maternal …
View article: PB0686 Clinical Decisions and Factors Influencing the Management of Persons with Hemophilia Requiring Antithrombotic Therapy: A Qualitative Study
PB0686 Clinical Decisions and Factors Influencing the Management of Persons with Hemophilia Requiring Antithrombotic Therapy: A Qualitative Study Open
Background:The global population is growing; those over 65 years are the leading demographic.People with bleeding disorders (PWBD) are living longer than ever and experiencing diseases of ageing with specific management challenges.Little h…
View article: Red blood cell transfusion in sickle cell disease
Red blood cell transfusion in sickle cell disease Open
Most patients with sickle cell disease will require RBC transfusions. At a Canadian centre, 60% of patients received 1 or more RBC transfusions per year, with a subset receiving more than 100 RBC units per year.[1][1] Transfusion can impro…
View article: Bleeding disorders and postpartum hemorrhage by mode of delivery: a retrospective cohort study
Bleeding disorders and postpartum hemorrhage by mode of delivery: a retrospective cohort study Open
In our cohort, high rates of PPH remained an important complication for pregnant persons with bleeding disorders. There was no significant difference in PPH based on modes of delivery. The small sample size likely limited the power of our …
View article: Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial Open
In the version of this Article initially published, a versioning error led to a mistake in the third paragraph of the Discussion.In the text now reading "In our dataset, the most extreme and sustained increase in SARS-CoV-2 cases associate…
View article: Cost-effectiveness of eltrombopag vs intravenous immunoglobulin for the perioperative management of immune thrombocytopenia
Cost-effectiveness of eltrombopag vs intravenous immunoglobulin for the perioperative management of immune thrombocytopenia Open
Eltrombopag has been shown to be noninferior to intravenous immunoglobulin (IVIG) for improving perioperative platelet counts in patients with immune thrombocytopenia (ITP) in a randomized trial; thus, cost is an important factor for treat…
View article: Blood transfusion and the risk for infections in kidney transplant patients
Blood transfusion and the risk for infections in kidney transplant patients Open
Background Receipt of a red blood cell transfusion (RBCT) post-kidney transplantation may alter immunity which could predispose to subsequent infection. Methods We carried out a single-center, retrospective cohort study of 1,258 adult kidn…
View article: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial Open
The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear. Although most randomized controlled trials have shown negative results, uncontrolled studies have suggested that the antibody content could influence p…
View article: New onset of acute heavy menstrual bleeding in a 34-year-old woman
New onset of acute heavy menstrual bleeding in a 34-year-old woman Open
A 34-year-old woman presented to the emergency department with a 1-day history of heavy menstrual bleeding. She described needing to use thick pads or diapers that required changing hourly because of the heavy flow of blood. One month prev…
View article: Convalescent plasma for hospitalized patients with COVID-19 and the effect of plasma antibodies: a randomized controlled, open-label trial
Convalescent plasma for hospitalized patients with COVID-19 and the effect of plasma antibodies: a randomized controlled, open-label trial Open
The efficacy of convalescent plasma for COVID-19 is unclear. While most randomized controlled trials have shown negative results, uncontrolled studies have suggested that the antibody content may influence patient outcomes. We conducted an…
View article: A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing Intraoperative Red Blood Cell Transfusion Strategies
A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing Intraoperative Red Blood Cell Transfusion Strategies Open
Objective: The objective of this work was to carry out a meta-analysis of RCTs comparing intraoperative RBC transfusion strategies to determine their impact on postoperative morbidity, mortality, and blood product use. Summary of Backgroun…