Alan W. Leung
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View article: Procollagen IIA mediates positive feedback control of the mouse cardiogenic transcriptional network
Procollagen IIA mediates positive feedback control of the mouse cardiogenic transcriptional network Open
Cardiogenesis relies on the integrated interplay between cardiac transcription factors and signaling pathways. Here, we uncover a role for type IIA procollagen (IIA), an extracellular matrix (ECM) protein encoded by an alternatively splice…
View article: Differentiation of Human Pluripotent Stem Cells Into Definitive Endoderm Cells in Various Flexible Three-Dimensional Cell Culture Systems: Possibilities and Limitations
Differentiation of Human Pluripotent Stem Cells Into Definitive Endoderm Cells in Various Flexible Three-Dimensional Cell Culture Systems: Possibilities and Limitations Open
The generation of human stem cell-derived spheroids and organoids represents a major step in solving numerous medical, pharmacological, and biological challenges. Due to the advantages of three-dimensional (3D) cell culture systems and the…
View article: Pre-Border Gene Foxb1 Regulates the Differentiation Timing and Autonomic Neuronal Potential of Human Neural Crest Cells
Pre-Border Gene Foxb1 Regulates the Differentiation Timing and Autonomic Neuronal Potential of Human Neural Crest Cells Open
SUMMARY What are the factors that are induced during the transitory phases from pluripotent stem cells to lineage specified cells, how are they regulated, and what are their functional contributions are fundamental questions for basic deve…
View article: WNT/β-CATENIN modulates the axial identity of ES derived human neural crest
WNT/β-CATENIN modulates the axial identity of ES derived human neural crest Open
The WNT/β-CATENIN pathway is critical for neural crest (NC) formation. However, the effects of the magnitude of the signal remains poorly defined. Here we evaluate the consequences of WNT magnitude variation in a robust model of human NC f…
View article: WNT/β-CATENIN modulates the axial identity of ES derived human neural crest
WNT/β-CATENIN modulates the axial identity of ES derived human neural crest Open
WNT/β-CATENIN signaling is critical for neural crest (NC) formation, yet magnitude effects of the signal remain ill-defined. Using a robust model of human NC formation based on human pluripotent stem cells (hPSCs), we expose that the WNT s…
View article: Mutations in Hnrnpa1 cause congenital heart defects
Mutations in Hnrnpa1 cause congenital heart defects Open
Incomplete penetrance of congenital heart defects (CHDs) was observed in a mouse model. We hypothesized that the contribution of a major genetic locus modulates the manifestation of the CHDs. After genome-wide linkage mapping, fine mapping…
View article: Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia
Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia Open
Neocortical basal radial glia (bRG) and cerebellar Bergmann glia (BG) are basal progenitors derived from ventricular apical radial glia (aRG) that selectively lose their apical processes. bRG and BG have been implicated in the expansion an…
View article: Author response: Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia
Author response: Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neocortical basal radial glia…
View article: WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate
WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate Open
Neural crest (NC) cells arise early in vertebrate development, migrate extensively and contribute to a diverse array of ectodermal and mesenchymal derivatives. Previous models of NC formation suggested derivation from neuralized ectoderm, …