Alana L. Whitcombe
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View article: Longitudinal surveillance of group A streptococcal pharyngitis and impetigo in remote Western Australian school children informs acute rheumatic fever prevention
Longitudinal surveillance of group A streptococcal pharyngitis and impetigo in remote Western Australian school children informs acute rheumatic fever prevention Open
The prevalence of impetigo and pharyngitis – which are both superficial group A streptococcus (GAS) infections that precede acute rheumatic fever – is poorly defined. Guidelines recommend the early diagnosis of both infections to prevent A…
View article: Antibody responses against bacterial glycans affinity mature and diversify in germinal centers
Antibody responses against bacterial glycans affinity mature and diversify in germinal centers Open
Summary Anti-carbohydrate antibodies (Abs) play crucial roles in pathogen control, but their generation remains poorly understood. By studying responses to Streptococcus pyogenes in humans, we reveal that the glycan-targeted response shift…
View article: Characterization of an IL-8 cleavage inhibition assay to determine the functionality of anti-SpyCEP antibodies in human sera
Characterization of an IL-8 cleavage inhibition assay to determine the functionality of anti-SpyCEP antibodies in human sera Open
Exposure to Group A Streptococcus leads to a broad spectrum of disease and sequelae, as the bacterium employs a wide range of virulence factors to facilitate colonization of the host, propagation and onward transmission, disrupting both in…
View article: Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections
Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections Open
Knowledge gaps regarding human immunity to Streptococcus pyogenes have impeded vaccine development. To address these gaps and evaluate vaccine candidates, we established a human challenge model of S. pyogenes pharyngitis. Here, we analyse …
View article: <i>Streptococcus pyogenes</i>pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections
<i>Streptococcus pyogenes</i>pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections Open
Knowledge gaps regarding human immunity to Streptococcus pyogenes have impeded vaccine development. To address these gaps and evaluate vaccine candidates, we established a human challenge model of S. pyogenes pharyngitis. Here, we analysed…
View article: Increased Breadth of Group A <i>Streptococcus</i> Antibody Responses in Children With Acute Rheumatic Fever Compared to Precursor Pharyngitis and Skin Infections
Increased Breadth of Group A <i>Streptococcus</i> Antibody Responses in Children With Acute Rheumatic Fever Compared to Precursor Pharyngitis and Skin Infections Open
Background Group A Streptococcus (GAS) causes superficial pharyngitis and skin infections as well as serious autoimmune sequelae such as acute rheumatic fever (ARF) and subsequent rheumatic heart disease. ARF pathogenesis remains poorly un…
View article: Combining antibody markers for serosurveillance of SARS-CoV-2 to estimate seroprevalence and time-since-infection – CORRIGENDUM
Combining antibody markers for serosurveillance of SARS-CoV-2 to estimate seroprevalence and time-since-infection – CORRIGENDUM Open
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View article: Combining antibody markers for serosurveillance of SARS-CoV-2 to estimate seroprevalence and time-since-infection
Combining antibody markers for serosurveillance of SARS-CoV-2 to estimate seroprevalence and time-since-infection Open
Serosurveillance is an important epidemiologic tool for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), used to estimate infection rates and the degree of population immunity. There is no general agreement on which antibody b…
View article: Combining antibody markers for serosurveillance of SARS-CoV-2 to estimate seroprevalence and time-since-infection
Combining antibody markers for serosurveillance of SARS-CoV-2 to estimate seroprevalence and time-since-infection Open
Summary Serosurveillance is an important epidemiologic tool for SARS-CoV-2, used to estimate burden of disease and degree of population immunity. Which antibody biomarker, and the optimal number of biomarkers, has not been well-established…
View article: Charting Elimination in the Pandemic: A SARS-CoV-2 Serosurvey of Blood Donors in New Zealand
Charting Elimination in the Pandemic: A SARS-CoV-2 Serosurvey of Blood Donors in New Zealand Open
A large-scale SARS-CoV-2 serosurvey of New Zealand blood donors (n=9806) was conducted at the end of 2020. Seroprevalence, after adjusting for test sensitivity and specificity, was very low (0.1%). This finding is consistent with limited c…
View article: Charting elimination in the pandemic: a SARS-CoV-2 serosurvey of blood donors in New Zealand
Charting elimination in the pandemic: a SARS-CoV-2 serosurvey of blood donors in New Zealand Open
New Zealand has a strategy of eliminating SARS-CoV-2 that has resulted in a low incidence of reported coronavirus-19 disease (COVID-19). The aim of this study was to describe the spread of SARS-CoV-2 in New Zealand via a nationwide serosur…
View article: Comprehensive analysis of SARS‐CoV‐2 antibody dynamics in New Zealand
Comprehensive analysis of SARS‐CoV‐2 antibody dynamics in New Zealand Open
Objectives Circulating antibodies are important markers of previous infection and immunity. Questions remain with respect to the durability and functionality of SARS‐CoV‐2 antibodies. This study explored antibody responses in recovered COV…
View article: Comprehensive analysis of SARS-CoV-2 antibody dynamics in New Zealand
Comprehensive analysis of SARS-CoV-2 antibody dynamics in New Zealand Open
Objectives Circulating antibodies are important markers of previous infection and immunity. Questions remain with respect to the durability and functionality of SARS-CoV-2 antibodies. This study explored antibody responses in recovered COV…
View article: SARS-CoV-2 antibodies in the Southern Region of New Zealand, 2020
SARS-CoV-2 antibodies in the Southern Region of New Zealand, 2020 Open
Background During New Zealand’s first outbreak in early 2020 the Southern Region had the highest per capita SARS-CoV-2 infection rate. PCR testing was initially limited by a narrow case definition and limited laboratory capacity, so cases …
View article: Peer Review #2 of "Collaborative networks enable the rapid establishment of serological assays for SARS-CoV-2 during nationwide lockdown in New Zealand (v0.1)"
Peer Review #2 of "Collaborative networks enable the rapid establishment of serological assays for SARS-CoV-2 during nationwide lockdown in New Zealand (v0.1)" Open
Conclusions: These serological assays were established and assessed at a time when human activity was severely restricted in New Zealand.This was achieved by generous sharing of reagents and technical expertise by the international scienti…
View article: Collaborative networks enable the rapid establishment of serological assays for SARS-CoV-2 during nationwide lockdown in New Zealand
Collaborative networks enable the rapid establishment of serological assays for SARS-CoV-2 during nationwide lockdown in New Zealand Open
Background Serological assays that detect antibodies to SARS-CoV-2 are critical for determining past infection and investigating immune responses in the COVID-19 pandemic. We established ELISA-based immunoassays using locally produced anti…
View article: Peer Review #1 of "Collaborative networks enable the rapid establishment of serological assays for SARS-CoV-2 during nationwide lockdown in New Zealand (v0.1)"
Peer Review #1 of "Collaborative networks enable the rapid establishment of serological assays for SARS-CoV-2 during nationwide lockdown in New Zealand (v0.1)" Open
Conclusions: These serological assays were established and assessed at a time when human activity was severely restricted in New Zealand.This was achieved by generous sharing of reagents and technical expertise by the international scienti…
View article: Development and Evaluation of a New Triplex Immunoassay That Detects Group A <i>Streptococcus</i> Antibodies for the Diagnosis of Rheumatic Fever
Development and Evaluation of a New Triplex Immunoassay That Detects Group A <i>Streptococcus</i> Antibodies for the Diagnosis of Rheumatic Fever Open
Streptococcal serology is a cornerstone in the diagnosis of acute rheumatic fever (ARF), a postinfectious sequela associated with group A Streptococcus infection. Current tests that measure anti-streptolysin O (ASO) and anti-DNaseB (ADB) t…
View article: Analysis of the <i>Escherichia coli</i> extracellular vesicle proteome identifies markers of purity and culture conditions
Analysis of the <i>Escherichia coli</i> extracellular vesicle proteome identifies markers of purity and culture conditions Open
Bacteria release nano‐sized extracellular vesicles (EVs) into the extracellular milieu. Bacterial EVs contain molecular cargo originating from the parent bacterium and have important roles in bacterial survival and pathogenesis. Using 8‐pl…