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View article: 1054 Myeloid and T cell subsets defined in bladder cancer using single-cell RNA sequencing and paired protein profiling
1054 Myeloid and T cell subsets defined in bladder cancer using single-cell RNA sequencing and paired protein profiling Open
Background Muscle-invasive bladder cancer (MIBC) has a 5-year survival of only 50% despite preoperative chemotherapy and radical cystectomy. For non-muscle-invasive bladder cancer (NMIBC), the 5-year survival rate is > 80%, but the local r…
View article: Transcriptional profiling demonstrates altered characteristics of <scp>CD8</scp><sup>+</sup> cytotoxic T‐cells and regulatory T‐cells in <i><scp>TP53</scp>‐</i>mutated acute myeloid leukemia
Transcriptional profiling demonstrates altered characteristics of <span>CD8</span><sup>+</sup> cytotoxic T‐cells and regulatory T‐cells in <i><span>TP53</span>‐</i>mutated acute myeloid leukemia Open
Background Acute myeloid leukemia (AML) patients have limited effect from T‐cell‐based therapies, such as PD‐1 and CTLA‐4 blockade. However, recent data indicate that AML patients with TP53 mutation have higher immune infiltration and othe…
View article: Dual role of the miR‐146 family in rhinovirus‐induced airway inflammation and allergic asthma exacerbation
Dual role of the miR‐146 family in rhinovirus‐induced airway inflammation and allergic asthma exacerbation Open
Rhinovirus (RV) infections are associated with asthma exacerbations. MicroRNA‐146a and microRNA‐146b (miR‐146a/b) are anti‐inflammatory miRNAs that suppress signaling through the nuclear factor kappa B (NF‐κB) pathway and inhibit pro‐infla…
View article: 839 Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer
839 Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer Open
Background: Bladder cancer is categorized as non-muscle invasive (NMIBC) or muscle invasive (MIBC). NIMBC makes up around 70% of the cases and although it is less aggressive, the recurrence rate is 50-70%, thus requiring extensive monitori…
View article: Reduced expression of miR-146a in human bronchial epithelial cells alters neutrophil migration
Reduced expression of miR-146a in human bronchial epithelial cells alters neutrophil migration Open
Background The role of miRNAs in the pathogenesis and determining the phenotypes of asthma is not fully elucidated. miR-146a has been previously shown to suppress inflammatory responses in different cells. In this study, we investigated th…
View article: miR‐10a‐5p is increased in atopic dermatitis and has capacity to inhibit keratinocyte proliferation
miR‐10a‐5p is increased in atopic dermatitis and has capacity to inhibit keratinocyte proliferation Open
Background miR‐10a‐5p has been shown to regulate cancer cell proliferation and invasiveness and endothelial cell inflammatory responses. The function of miR‐10a‐5p in the skin has not been previously studied. The aim of the current study w…
View article: Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis
Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis Open
Intratonsillar T cell and interferon gene expressions appeared to be relatively stable for both tonsillar hypertrophy and recurrent tonsillitis. Of the studied cytokines, only newly discovered anti-inflammatory cytokine IL-37, was independ…
View article: Human rhinoviruses enter and induce proliferation of B lymphocytes
Human rhinoviruses enter and induce proliferation of B lymphocytes Open
Our results demonstrate for the first time that HRVs enter and form viral replication centers in B lymphocytes and induce the proliferation of B cells. Newly formed virions have the capacity to infect other cells (HeLa). These findings ind…