Explanipedia

Methacrylic acid-based biomaterials promote peripheral innervation in the subcutaneous space of mice Open

Alaura Androschuk, Theresa H. Tam, Redouan Mahou, Cheun Lo, Michael W. Salter , et al. · 2022

Peripheral nerve innervation is essential for regulating tissue repair and regeneration. MAA-based biomaterials have been previously shown to promote angiogenesis. Here we show a new role for MAA-based biomaterials in promoting terminal ax…

Acquisition of a Unique Mesenchymal Precursor-like Blastema State Underlies Successful Adult Mammalian Digit Tip Regeneration Open

Mekayla A. Storer, Neemat Mahmud, Konstantina Karamboulas, Michael J. Borrett, Scott A. Yuzwa , et al. · 2020

Stress Odorant Sensory Response Dysfunction in Drosophila Fragile X Syndrome Mutants Open

Alaura Androschuk, Richard X. He, Savannah Weber, Cory Rosenfelt, François V. Bolduc · 2018

Sensory processing dysfunction (SPD) is present in most patients with intellectual disability (ID) and autism spectrum disorder (ASD). Silencing expression of the Fragile X mental retardation 1 (FMR1) gene leads to Fragile X syndrom…

Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia Open

Ziv Gan‐Or, Naïma Bouslam, Nazha Birouk, Alexandra Lissouba, Daniel B. Chambers , et al. · 2016

Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia Open

Ziv Gan‐Or, Naïma Bouslam, Nazha Birouk, Alexandra Lissouba, Daniel B. Chambers , et al. · 2016

Conserved pharmacological rescue of hereditary spastic paraplegia-related phenotypes across model organisms Open

Carl Julien, Alexandra Lissouba, Surya T. Madabattula, Yasmin Fardghassemi, Cory Rosenfelt , et al. · 2016

Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative diseases causing progressive gait dysfunction. Over 50 genes have now been associated with HSP. Despite the recent explosion in genetic knowledge, HSP remains without p…

Cyclic Adenosine Monophosphate (cAMP) and Fragile X Mental Retardation Protein (FMRP) Mediate Avoidance Behaviour in Drosophila Open

Alaura Androschuk · 2016

Fragile X Syndrome (FXS) is neurodevelopmental disorder caused by a trinucleotide CGG repeat expansion that leads to the methylation and transcriptional silencing of the Fragile X mental retardation 1 (fmr1) gene. This results in the loss …

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders Open

Surya T. Madabattula, Joel C. Strautman, Andrew Bysice, Julia O’Sullivan, Alaura Androschuk , et al. · 2015

Locomotive defects resulting from neurodegenerative disorders can be a late onset symptom of disease, following years of subclinical degeneration, and thus current therapeutic treatment strategies are not curative. Through the use of whole…

From Learning to Memory: What Flies Can Tell Us about Intellectual Disability Treatment Open

Alaura Androschuk, Basma Al-Jabri, François V. Bolduc · 2015

Intellectual disability (ID), previously known as mental retardation, affects 3% of the population and remains without pharmacological treatment. ID is characterized by impaired general mental abilities associated with defects in adaptive …

Insulin signaling is acutely required for long-term memory in Drosophila Open

Daniel B. Chambers, Alaura Androschuk, Cory Rosenfelt, Steven Langer, Mark Geoffrey Harding , et al. · 2015

Memory formation has been shown recently to be dependent on energy status in Drosophila. A well-established energy sensor is the insulin signaling (InS) pathway. Previous studies in various animal models including human have revealed the r…

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