Alayna C. Caruso
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View article: Targeting intracellular tau with a gene-encoded single-chain antibody promotes neuronal homeostasis and ameliorates tau pathology
Targeting intracellular tau with a gene-encoded single-chain antibody promotes neuronal homeostasis and ameliorates tau pathology Open
The intraneuronal aggregation of tau is a key driver of pathogenesis in tauopathies such as Alzheimer’s disease. Passive immunotherapy is a promising strategy for targeting tau, with several tau-specific antibodies having demonstrated the …
View article: Delivery of mRNA encoding an anti‐tau monoclonal antibody and engineered scFv intrabody results in functional antibody expression in neurons
Delivery of mRNA encoding an anti‐tau monoclonal antibody and engineered scFv intrabody results in functional antibody expression in neurons Open
Background Monoclonal antibodies have emerged as a leading therapeutic agent for the treatment of disease, including Alzheimer’s disease. Such antibodies, however, are expensive and timely to produce and require frequent dosing regimens to…
View article: Messenger RNA-encoded antibody approach for targeting extracellular and intracellular tau
Messenger RNA-encoded antibody approach for targeting extracellular and intracellular tau Open
Monoclonal antibodies have emerged as a leading therapeutic agent for the treatment of disease, including Alzheimer’s disease. In the last year, two anti-amyloid monoclonal antibodies, lecanemab and aducanumab, have been approved in the US…
View article: Neuronal targeting of tau using a mRNA‐encoded tau‐specific antibody fragment
Neuronal targeting of tau using a mRNA‐encoded tau‐specific antibody fragment Open
Background A promising target for the treatment of Alzheimer’s disease and related tauopathies is intraneuronal tau. We have generated conventional tau‐specific monoclonal antibodies, as well as engineered antibody fragments, and demonstra…
View article: Delivery of mRNA encoding an anti-tau monoclonal antibody and engineered scFv intrabody results in functional antibody expression in SH-SY5Y cells
Delivery of mRNA encoding an anti-tau monoclonal antibody and engineered scFv intrabody results in functional antibody expression in SH-SY5Y cells Open
Monoclonal antibodies have emerged as a leading therapeutic agent for the treatment of disease, including Alzheimer’s disease. In the last year, two anti-amyloid monoclonal antibodies, lecanemab and aducanumab, have been approved in the US…
View article: Current and Emerging Strategies for Enhancing Antibody Delivery to the Brain
Current and Emerging Strategies for Enhancing Antibody Delivery to the Brain Open
For the treatment of neurological diseases, achieving sufficient exposure to the brain parenchyma is a critical determinant of drug efficacy. The blood–brain barrier (BBB) functions to tightly control the passage of substances between the …