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View article: Single versus combination treatment in tinnitus: an international, multicentre, parallel-arm, superiority, randomised controlled trial
Single versus combination treatment in tinnitus: an international, multicentre, parallel-arm, superiority, randomised controlled trial Open
Tinnitus is defined as the conscious awareness of a tonal or composite noise in the absence of a corresponding external acoustic source. This international multicentre, parallel-arm, superiority, randomised controlled trial investigated wh…
View article: Different Contribution of Missense and Loss‐of‐Function Variants to the Genetic Structure of Familial and Sporadic Meniere Disease
Different Contribution of Missense and Loss‐of‐Function Variants to the Genetic Structure of Familial and Sporadic Meniere Disease Open
Meniere disease (MD) is a chronic inner ear disorder with significant heritability. This study compares the burden of rare high‐ and moderate‐impact coding variants in an MD cohort to determine whether genetic burden in sporadic MD (SMD) o…
View article: Different contribution of missense and loss-of-function variants to the genetic structure of familial and sporadic Meniere disease
Different contribution of missense and loss-of-function variants to the genetic structure of familial and sporadic Meniere disease Open
Meniere disease (MD) is a chronic inner ear disorder with significant heritability. This study aims to compare the burden of rare high- and moderate-impact protein-coding variants in a MD cohort to determine whether the genetic burden in s…
View article: Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease: A longitudinal study
Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease: A longitudinal study Open
Identified immunophenotypes, allergy-driven IgE responses, and IL-1β-mediated autoinflammation indicate that targeting inflammation with biomarkers could optimize MD treatment and outcomes.
View article: Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease
Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease Open
Meniere disease (MD) is an inner ear disorder associated with genetic and environmental factors. Several triggers may induce an inflammatory response that may persist over time, leading to a chronic inflammatory process. This study aims to…
View article: A rare haplotype of the<i>GJD3</i>gene segregating in familial Meniere Disease interferes with connexin assembly
A rare haplotype of the<i>GJD3</i>gene segregating in familial Meniere Disease interferes with connexin assembly Open
Familial Meniere Disease (FMD) is a rare polygenic disorder of the inner ear. Mutations in the connexin gene family, which encodes gap junction proteins, can also cause hearing loss, but their role in FMD is largely unknown. Here, we found…
View article: Single versus Combination Treatment in Tinnitus: An International, Multicentre, Parallel-arm, Superiority, Randomised Controlled Trial
Single versus Combination Treatment in Tinnitus: An International, Multicentre, Parallel-arm, Superiority, Randomised Controlled Trial Open
Tinnitus is associated with a variety of aetiologies, phenotypes, and underlying pathophysiological mechanisms, and available treatments have limited efficacy. A combination of treatments, addressing various aspects of tinnitus, might prov…
View article: Rare Deletions or Large Duplications Contribute to Genetic Variation in Patients with Severe Tinnitus and Meniere Disease
Rare Deletions or Large Duplications Contribute to Genetic Variation in Patients with Severe Tinnitus and Meniere Disease Open
Meniere disease (MD) is a debilitating disorder of the inner ear defined by sensorineural hearing loss (SNHL) associated with episodes of vertigo and tinnitus. Severe tinnitus, which occurs in around 1% of patients, is a multiallelic disor…
View article: The Statistical Analysis Plan for the Unification of Treatments and Interventions for Tinnitus Patients Randomized Clinical Trial (UNITI-RCT)
The Statistical Analysis Plan for the Unification of Treatments and Interventions for Tinnitus Patients Randomized Clinical Trial (UNITI-RCT) Open
Background Tinnitus is a leading cause of disease burden globally. Several therapeutic strategies are recommended in guidelines for the reduction of tinnitus distress; however, little is known about the potential increased effectiveness of…
View article: Aggregated variant data from whole-genome sequenced tinnitus patients (TIGER)
Aggregated variant data from whole-genome sequenced tinnitus patients (TIGER) Open
Aggregated variant data obtained from tinnitus patients from Sweden. Uploaded datasets are storage in annotated csv files. Annotation was performed using VEP (v106), including population frequencies for each variant from gnomAD, non-finnis…
View article: Aggregated variant data from whole-genome sequenced tinnitus patients (TIGER)
Aggregated variant data from whole-genome sequenced tinnitus patients (TIGER) Open
Aggregated variant data obtained from tinnitus patients from Sweden. Uploaded datasets are storage in annotated csv files. Annotation was performed using VEP (v106), including population frequencies for each variant from gnomAD, non-finnis…
View article: Single cell profiling reveals a reduction of CD56dim NK-cells and other immune cells in patients with Meniere disease and high levels of cytokines
Single cell profiling reveals a reduction of CD56dim NK-cells and other immune cells in patients with Meniere disease and high levels of cytokines Open
Background Meniere Disease (MD) is an inner ear syndrome, characterized by sensorineural hearing loss associated with episodes of vertigo, tinnitus, and aural fullness. The pathological mechanism leading to sporadic MD is still poorly unde…
View article: Defective α‐tectorin may involve tectorial membrane in familial Meniere disease
Defective α‐tectorin may involve tectorial membrane in familial Meniere disease Open
Dear Editor Although there have been considerable advances in recent years, the contribution of genetic factors to Meniere's disease (MD) is not yet fully understood. MD (OMIM 156000) is an inner ear disorder defined by episodes of vertigo…
View article: Ultrarare missense and frameshift variants in the <i>TECTA</i> gene may involve tectorial membrane in familial Meniere disease
Ultrarare missense and frameshift variants in the <i>TECTA</i> gene may involve tectorial membrane in familial Meniere disease Open
Background Meniere’s disease (MD) is an inner ear disease defined by episodes of vertigo associated with sensorineural hearing loss initially affecting low- to medium frequencies, tinnitus, and aural fullness. Familial aggregation has been…
View article: DNA Methylation Signature in Mononuclear Cells and Proinflammatory Cytokines May Define Molecular Subtypes in Sporadic Meniere Disease
DNA Methylation Signature in Mononuclear Cells and Proinflammatory Cytokines May Define Molecular Subtypes in Sporadic Meniere Disease Open
Meniere Disease (MD) is a multifactorial disorder of the inner ear characterized by vertigo attacks associated with sensorineural hearing loss and tinnitus with a significant heritability. Although MD has been associated with several genes…
View article: DNA Methylation Signature in Mononuclear Cells and Proinflammatory Cytokines May Define Molecular Subtypes in Sporadic Meniere Disease
DNA Methylation Signature in Mononuclear Cells and Proinflammatory Cytokines May Define Molecular Subtypes in Sporadic Meniere Disease Open
Meniere Disease (MD) is a multifactorial disorder of the inner ear characterized by vertigo attacks associated with sensorineural hearing loss and tinnitus with a significant heritability. Although MD has been associated with several genes…
View article: Unification of treatments and interventions for tinnitus patients (UNITI): a study protocol for a multi-center randomized clinical trial
Unification of treatments and interventions for tinnitus patients (UNITI): a study protocol for a multi-center randomized clinical trial Open
Background Tinnitus represents a relatively common condition in the global population accompanied by various comorbidities and severe burden in many cases. Nevertheless, there is currently no general treatment or cure, presumable due to th…
View article: Additional file 1 of Unification of Treatments and Interventions for Tinnitus Patients (UNITI): a study protocol for a multi-center randomized clinical trial
Additional file 1 of Unification of Treatments and Interventions for Tinnitus Patients (UNITI): a study protocol for a multi-center randomized clinical trial Open
Additional file 1. Ethical approvals from Germany, Spain, Greece and Belgium. Informed consent form – RCT. Information sheet – RCT. Informed consent form – blood sampling. Information sheet – blood sampling. UNITI data management plan. WHO…
View article: Systematic Review of Sequencing Studies and Gene Expression Profiling in Familial Meniere Disease
Systematic Review of Sequencing Studies and Gene Expression Profiling in Familial Meniere Disease Open
Familial Meniere Disease (FMD) is a rare inner ear disorder characterized by episodic vertigo associated with sensorineural hearing loss, tinnitus and/or aural fullness. We conducted a systematic review to find sequencing studies segregati…