Alba Garrido-Trigo
YOU?
Author Swipe
View article: Differential effects of tofacitinib on macrophage activation contribute to lack of response in ulcerative colitis patients
Differential effects of tofacitinib on macrophage activation contribute to lack of response in ulcerative colitis patients Open
Background and Aims Tofacitinib, a Janus kinase inhibitor, is approved for the treatment of moderate-to-severe ulcerative colitis. Nonetheless, 40-60% of patients will not respond adequately. The mechanisms underlying responses to tofaciti…
View article: Single-cell integration reveals metaplasia in inflammatory gut diseases
Single-cell integration reveals metaplasia in inflammatory gut diseases Open
The gastrointestinal tract is a multi-organ system crucial for efficient nutrient uptake and barrier immunity. Advances in genomics and a surge in gastrointestinal diseases 1,2 has fuelled efforts to catalogue cells constituting gastrointe…
View article: Understanding the mechanisms underlying the lack of response to Janus kinase inhibition in ulcerative colitis
Understanding the mechanisms underlying the lack of response to Janus kinase inhibition in ulcerative colitis Open
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. About one-third of UC patients failed to respond to available drugs, including tofacitinib, a broad Janus kinase (JAK) inhibitor. However, the mechanisms underlying pa…
View article: Single Cell Integration Characterises Metaplasia in Inflammatory Intestinal Diseases
Single Cell Integration Characterises Metaplasia in Inflammatory Intestinal Diseases Open
The gastrointestinal (GI) tract consists of connected organs, from the oral cavity to rectum, which function to ensure efficient nutrient uptake and barrier immunity. Diseases of the GI tract affect millions worldwide and as such there are…
View article: Author Correction: Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
Author Correction: Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease Open
View article: DOP45 Blood-derived neutrophils give rise to differentially activated populations in the mucosa of active Inflammatory Bowel Disease patients
DOP45 Blood-derived neutrophils give rise to differentially activated populations in the mucosa of active Inflammatory Bowel Disease patients Open
Background Infiltration of neutrophils is the main histological feature in active inflammatory bowel disease (IBD). Recent data suggests that tissue- and tumour-infiltrating neutrophils can adopt remarkably different phenotypes with potent…
View article: DOP87 Characterization of pathologic fibroblast and macrophage cell populations in colonic Crohn’s Disease with spatial transcriptomics
DOP87 Characterization of pathologic fibroblast and macrophage cell populations in colonic Crohn’s Disease with spatial transcriptomics Open
Background Single-cell transcriptomic data of the human intestine has shed new light on the cellular composition and heterogeneity present in healthy and diseased tissues. Nonetheless, little information is currently available on their spa…
View article: P026 Differential effects of tofacitinib on macrophage activation may contribute to lack of response in ulcerative colitis patients
P026 Differential effects of tofacitinib on macrophage activation may contribute to lack of response in ulcerative colitis patients Open
Background We previously showed that ulcerative colitis (UC) patients refractory to tofacitinib present an increase in the activation and the pro-inflammatory profile of intestinal macrophages1. However, the mechanism by which tofacitinib …
View article: Uncovering intestinal macrophages through the integration of single-cell and spatial transcriptomics
Uncovering intestinal macrophages through the integration of single-cell and spatial transcriptomics Open
View article: Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease Open
View article: DOP05 Single-cell RNAseq temporal analysis of ulcerative colitis patients undergoing tofacitinib treatment reveals a shift in myeloid cells towards pro-inflammatory phenotypes in refractory patients
DOP05 Single-cell RNAseq temporal analysis of ulcerative colitis patients undergoing tofacitinib treatment reveals a shift in myeloid cells towards pro-inflammatory phenotypes in refractory patients Open
Background Tofacitinib is an oral JAK1 and JAK3 inhibitor approved for the treatment of moderate to severe ulcerative colitis (UC). The aim of this study is to identify the relevant cellular subsets and genes involved in response and/or re…
View article: DOP65 T-cell derived TGFβ1 remodels the rectum mesenchyme in Crohn’s Disease patients with perianal fistulizing disease
DOP65 T-cell derived TGFβ1 remodels the rectum mesenchyme in Crohn’s Disease patients with perianal fistulizing disease Open
Background Perianal fistulizing disease (PFD) is a complication occurring in about 20% of Crohn’s Disease (CD) patients. It consists of the formation of new epithelised tracks connecting the intestine with the outer perianal region, which …
View article: Macrophage and neutrophil heterogeneity at single-cell spatial resolution in inflammatory bowel disease
Macrophage and neutrophil heterogeneity at single-cell spatial resolution in inflammatory bowel disease Open
Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic inflammatory intestinal diseases that show a perplexing heterogeneity in manifestations and response to treatment. The molecular basis for this heterogeneity remains uncharacteri…
View article: Randomized Controlled Trial Substudy of Cell-specific Mechanisms of Janus Kinase 1 Inhibition With Upadacitinib in the Crohn’s Disease Intestinal Mucosa: Analysis From the CELEST Study
Randomized Controlled Trial Substudy of Cell-specific Mechanisms of Janus Kinase 1 Inhibition With Upadacitinib in the Crohn’s Disease Intestinal Mucosa: Analysis From the CELEST Study Open
Background Janus kinase (JAK) inhibition shows promise for treatment of patients with moderate to severe Crohn’s disease. We aimed to provide mechanistic insights into the JAK1-selective inhibitor upadacitinib through a transcriptomics sub…
View article: Dissecting Common and Unique Effects of Anti-α4β7 and Anti-Tumor Necrosis Factor Treatment in Ulcerative Colitis
Dissecting Common and Unique Effects of Anti-α4β7 and Anti-Tumor Necrosis Factor Treatment in Ulcerative Colitis Open
Background and Aims Vedolizumab is an anti-α4β7 antibody approved for the treatment of ulcerative colitis [UC]. Although it is assumed that vedolizumab blocks intestinal homing of lymphocytes, its effects on different intestinal cell popul…
View article: Molecular Structure and Function of Janus Kinases: Implications for the Development of Inhibitors
Molecular Structure and Function of Janus Kinases: Implications for the Development of Inhibitors Open
Cytokines can trigger multiple signalling pathways, including Janus tyrosine kinases [JAK] and signal transducers and activators of transcription [STATS] pathways. JAKs are cytoplasmic proteins that, following the binding of cytokines to t…