Albert Alhatem
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View article: Carcinogenesis: An Alternative Hypothesis Comparing Mutagenic Versus Metabolic Models
Carcinogenesis: An Alternative Hypothesis Comparing Mutagenic Versus Metabolic Models Open
Carcinogenesis, while traditionally attributed to the accumulation of driver mutations in genes regulating cell proliferation and apoptosis, may also be explored as a consequence of fundamental metabolic reprogramming, an idea catalyzed by…
View article: Carcinogenesis: – Mutagenic Versus Metabolic Models: An Alternative Hypothesis
Carcinogenesis: – Mutagenic Versus Metabolic Models: An Alternative Hypothesis Open
Carcinogenesis, while traditionally attributed to the accumulation of driver mutations in genes regulating cell proliferation and apoptosis, may also be explored as a consequence of fundamental metabolic reprogramming, an idea catalyzed by…
View article: Dupilumab-Associated Sezary Syndrome
Dupilumab-Associated Sezary Syndrome Open
Dupilumab is a monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13), approved for the treatment of adults with moderate-to-severe atopic dermatitis (AD). While recent reports have described cases of new-onset m…
View article: Dupilumab-Associated Mycosis Fungoides; A Cross-Sectional Study
Dupilumab-Associated Mycosis Fungoides; A Cross-Sectional Study Open
Importance: Treating AD with dupilumab, a monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13), may be associated with progression of MF. Objective: To examine the associations between length of dupilumab treat…
View article: MANAGEMENT OF ARTIFICIAL NEURAL NETWORKS FOR RECOGNITION MAPPING OF HIGH-DEFINITION IMAGES
MANAGEMENT OF ARTIFICIAL NEURAL NETWORKS FOR RECOGNITION MAPPING OF HIGH-DEFINITION IMAGES Open
Background. Scientific article reveals the problem of analyzing, recognizing and managing highdefinition images with a minimum error due to the previous frame-by-frame recognition of a complex of lowdefinition images. The fundamental probl…
View article: Granuloma Annulare – A Manifestation of Primary Cutaneous Mucinous Carcinoma?
Granuloma Annulare – A Manifestation of Primary Cutaneous Mucinous Carcinoma? Open
The objective of this report is to present a rare case of primary cutaneous mucinous carcinoma (PCMC) manifesting with granuloma annulare (GA), and to discuss the association as a paraneoplastic phenomenon. A 65-year-old female presented w…
View article: Cytogenetic and molecular landscape and its potential clinical significance in Hispanic CMML patients from Puerto Rico
Cytogenetic and molecular landscape and its potential clinical significance in Hispanic CMML patients from Puerto Rico Open
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic neoplasm that exhibits myelodysplastic and myeloproliferative characteristics with heterogeneous clinical and pathological features. There are limited publications on the eth…
View article: Epidemiologic Features of NSCLC Gene Alterations in Hispanic Patients from Puerto Rico
Epidemiologic Features of NSCLC Gene Alterations in Hispanic Patients from Puerto Rico Open
Targeted therapy has changed the paradigm of advanced NSCLC management by improving the survival rate of patients carrying actionable gene alterations using specific inhibitors. The epidemiologic features of these alterations vary among ra…
View article: Correction to: Treatment of Rare and Aggressive Pancreatic Carcinosarcoma
Correction to: Treatment of Rare and Aggressive Pancreatic Carcinosarcoma Open
[This corrects the article on p. e00379 in vol. 7, PMID: 32607379.].
View article: Nivolumab-Induced Concomitant Severe Upper and Lower Gastrointestinal Immune-Related Adverse Effects
Nivolumab-Induced Concomitant Severe Upper and Lower Gastrointestinal Immune-Related Adverse Effects Open
Immunotherapy agents such as cytotoxic T-lymphocyte antigen-4 and programed cell death protein-1 inhibitors show efficacy in cancer therapy but are associated with immune-related adverse events. It commonly presents as diarrhea but can cau…
View article: Out-of-the-box soft tissue tumor: pediatric synovial sarcoma of larynx
Out-of-the-box soft tissue tumor: pediatric synovial sarcoma of larynx Open
Synovial sarcoma (SS) is a very rare, aggressive, mesenchymal neoplasm that displays both spindle cell and epithelial histologic characteristics. To our knowledge, there are only 20 documented cases of primary laryngeal SS in the English l…
View article: Behind the Skin: A Rare Case of Scurvy-Associated Megaloblastic Anemia
Behind the Skin: A Rare Case of Scurvy-Associated Megaloblastic Anemia Open
Scurvy, caused by vitamin C deficiency, is very rare nowadays in the developed world. Scattered cases are found in people with unusual eating habits, alcoholism, intestinal malabsorption, mental disorders, or elderly living alone. Because …
View article: Maxillary ameloblastoma in an 8-year-old child: A case report with a review of the literature
Maxillary ameloblastoma in an 8-year-old child: A case report with a review of the literature Open
Ameloblastoma is a benign locally invasive tumor with a high tendency to recur. It is considered rare in the pediatric population, with most cases diagnosed in the third to fifth decades of life. Approximately 80% of ameloblastomas occur i…
View article: Blocking the Necroptosis Pathway Decreases RPE and Photoreceptor Damage Induced by NaIO<sub>3</sub>
Blocking the Necroptosis Pathway Decreases RPE and Photoreceptor Damage Induced by NaIO<sub>3</sub> Open
Purpose Sodium iodate (NaIO3) has been extensively used as a retinotoxin to induce RPE cell damage and degeneration of photoreceptors in vitro and in vivo . RIP-Kinase dependent programmed necrosis is an important redundant cell death path…
View article: Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis
Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis Open
Consistent with other evidence supporting the role of inflammation and the immune system in AMD pathogenesis, AAbs were identified in AMD sera, including early-stage disease. Identified targets may be mechanistically linked to AMD pathogen…