Albert Comelli
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View article: Brain Fluidity as a Functional Marker of Tau-Related Neurodegeneration in Alzheimer’s Disease
Brain Fluidity as a Functional Marker of Tau-Related Neurodegeneration in Alzheimer’s Disease Open
Alzheimer’s Disease (AD) is the most common form of dementia and one of the leading neurodegenerative disorders worldwide. Neurophysiopathologically, AD is characterized by neuronal death, accompanied by the alteration of tau protein in th…
View article: Engineered collagen-coated scaffolds for tendon regeneration: a multifunctional drug delivery approach
Engineered collagen-coated scaffolds for tendon regeneration: a multifunctional drug delivery approach Open
Tendon injuries rank among the most common musculoskeletal disorders, with their incidence rising steadily due to increased sports participation and an aging population. Current surgical treatments often fall short of clinical expectations…
View article: Engineered collagen-coated scaffolds for tendon regeneration: a multifunctional drug delivery approach
Engineered collagen-coated scaffolds for tendon regeneration: a multifunctional drug delivery approach Open
Tendon injuries rank among the most common musculoskeletal disorders, with their incidence rising steadily due to increased sports participation and an aging population. Current surgical treatments often fall short of clinical expectations…
View article: Alpha-synuclein pathological deposition alters functional homeostasis and connectivity of striatal dopaminergic synapses and results in microglia activation, pathology spreading, muscle stiffness, whole brain atrophy and metabolic changes before producing frank nigral neuron deafferentation
Alpha-synuclein pathological deposition alters functional homeostasis and connectivity of striatal dopaminergic synapses and results in microglia activation, pathology spreading, muscle stiffness, whole brain atrophy and metabolic changes before producing frank nigral neuron deafferentation Open
The progressive accumulation of α-synuclein (α-Syn) aggregates is believed to contribute to Parkinson’s disease (PD) pathogenesis. Nevertheless, the earliest pre-degenerative molecular, functional, neuroinflammatory and metabolic changes a…
View article: An Update on DOTA-Peptides PET Imaging and Potential Advancements of Radioligand Therapy in Intracranial Meningiomas
An Update on DOTA-Peptides PET Imaging and Potential Advancements of Radioligand Therapy in Intracranial Meningiomas Open
Meningiomas arise from the meningeal layers covering the central nervous system structures. Although most are benign, meningiomas can still cause neurological morbidity due to the mass effect and compression of the surrounding parenchyma. …
View article: Revolutionizing Periodontal Care: The Role of Artificial Intelligence in Diagnosis, Treatment, and Prognosis
Revolutionizing Periodontal Care: The Role of Artificial Intelligence in Diagnosis, Treatment, and Prognosis Open
This review evaluates the application of artificial intelligence (AI), particularly neural networks, in diagnosing and staging periodontal diseases through radiographic analysis. Using a systematic review of 22 studies published between 20…
View article: Applications of Artificial Intelligence, Deep Learning, and Machine Learning to Support the Analysis of Microscopic Images of Cells and Tissues
Applications of Artificial Intelligence, Deep Learning, and Machine Learning to Support the Analysis of Microscopic Images of Cells and Tissues Open
Artificial intelligence (AI) transforms image data analysis across many biomedical fields, such as cell biology, radiology, pathology, cancer biology, and immunology, with object detection, image feature extraction, classification, and seg…
View article: Prevention and management of degenerative lumbar spine disorders through artificial intelligence-based decision support systems: a systematic review
Prevention and management of degenerative lumbar spine disorders through artificial intelligence-based decision support systems: a systematic review Open
AI-based DSS applications showed a high degree of accuracy in performing a wide set of different tasks. These findings lay the foundation for further research to improve the current understanding and encourage wider adoption of AI in clini…
View article: Artificial Intelligence and Statistical Models for the Prediction of Radiotherapy Toxicity in Prostate Cancer: A Systematic Review
Artificial Intelligence and Statistical Models for the Prediction of Radiotherapy Toxicity in Prostate Cancer: A Systematic Review Open
Background: Prostate cancer (PCa) is the second most common cancer in men, and radiotherapy (RT) is one of the main treatment options. Although effective, RT can cause toxic side effects. The accurate prediction of dosimetric parameters, e…
View article: 111Ag phantom images with Cerenkov Luminescence Imaging and digital autoradiography within the ISOLPHARM project
111Ag phantom images with Cerenkov Luminescence Imaging and digital autoradiography within the ISOLPHARM project Open
View article: A Robust [18F]-PSMA-1007 Radiomics Ensemble Model for Prostate Cancer Risk Stratification
A Robust [18F]-PSMA-1007 Radiomics Ensemble Model for Prostate Cancer Risk Stratification Open
The aim of this study is to investigate the role of [ 18 F]-PSMA-1007 PET in differentiating high- and low-risk prostate cancer (PCa) through a robust radiomics ensemble model. This retrospective study included 143 PCa patients who underwe…
View article: Theranostic Approaches for Gastric Cancer: An Overview of In Vitro and In Vivo Investigations
Theranostic Approaches for Gastric Cancer: An Overview of In Vitro and In Vivo Investigations Open
Gastric cancer (GC) is the second most common cause of cancer-related death worldwide and a serious public health concern. This high death rate is mostly caused by late-stage diagnoses, which lead to poor treatment outcomes. Radiation immu…
View article: Correction: PSMA‑positive prostatic volume prediction with deep learning based on T2‑weighted MRI
Correction: PSMA‑positive prostatic volume prediction with deep learning based on T2‑weighted MRI Open
View article: New Parametric 2D Curves for Modeling Prostate Shape in Magnetic Resonance Images
New Parametric 2D Curves for Modeling Prostate Shape in Magnetic Resonance Images Open
Geometric shape models often help to extract specific contours in digital images (the segmentation process) with major precision. Motivated by this idea, we introduce two models for the representation of prostate shape in the axial plane o…
View article: A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m
A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m Open
Rheumatoid arthritis (RA) is a systemic autoimmune disorder caused by inflammation of cartilaginous diarthrodial joints that destroys joints and cartilage, resulting in synovitis and pannus formation. Timely detection and effective managem…
View article: Radiomics Analysis of Preprocedural CT Imaging for Outcome Prediction after Transjugular Intrahepatic Portosystemic Shunt Creation
Radiomics Analysis of Preprocedural CT Imaging for Outcome Prediction after Transjugular Intrahepatic Portosystemic Shunt Creation Open
Purpose: To evaluate the role of radiomics in preoperative outcome prediction in cirrhotic patients who underwent transjugular intrahepatic portosystemic shunt (TIPS) using “controlled expansion covered stents”. Materials and Methods: This…
View article: High-Risk HPV CISH Detection in Cervical Biopsies with Weak and/or Focal p16 Immunohistochemical Positivity
High-Risk HPV CISH Detection in Cervical Biopsies with Weak and/or Focal p16 Immunohistochemical Positivity Open
In cervical biopsies, for diagnosis of Human Papilloma Virus (HPV) related conditions, the immunohistochemical staining for p16 has a diagnostic value only if diffusely and strongly positive, pattern named “block-like”. “Weak and/or focal …
View article: PSMA-positive prostatic volume prediction with deep learning based on T2-weighted MRI
PSMA-positive prostatic volume prediction with deep learning based on T2-weighted MRI Open
View article: Shearlet Transform Applied to a Prostate Cancer Radiomics Analysis on MR Images
Shearlet Transform Applied to a Prostate Cancer Radiomics Analysis on MR Images Open
For decades, wavelet theory has attracted interest in several fields in dealing with signals. Nowadays, it is acknowledged that it is not very suitable to face aspects of multidimensional data like singularities and this has led to the dev…
View article: Biodistribution Assessment of a Novel 68Ga-Labeled Radiopharmaceutical in a Cancer Overexpressing CCK2R Mouse Model: Conventional and Radiomics Methods for Analysis
Biodistribution Assessment of a Novel 68Ga-Labeled Radiopharmaceutical in a Cancer Overexpressing CCK2R Mouse Model: Conventional and Radiomics Methods for Analysis Open
The aim of the present study consists of the evaluation of the biodistribution of a novel 68Ga-labeled radiopharmaceutical, [68Ga]Ga-NODAGA-Z360, injected into Balb/c nude mice through histopathological analysis on bioptic samples and radi…
View article: Quantitative Evaluation by Digital Pathology of Immunohistochemical Expression of CK7, CK19, and EpCAM in Advanced Stages of NASH
Quantitative Evaluation by Digital Pathology of Immunohistochemical Expression of CK7, CK19, and EpCAM in Advanced Stages of NASH Open
(1) Background: Nonalcoholic Steatohepatitis/Nonalcoholic Fatty Liver Disease (NASH/NAFLD) is the most recurrent chronic liver disease. NASH could present with a cholestatic (C) or hepatic (H) pattern of damage. Recently, we observed that …
View article: Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent
Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent Open
Resveratrol is a polyphenolic compound that has gained considerable attention in the past decade due to its multifaceted therapeutic potential, including anti-inflammatory and anticancer properties. However, its anticancer efficacy is impe…
View article: Digital Pathology: A Comprehensive Review of Open-Source Histological Segmentation Software
Digital Pathology: A Comprehensive Review of Open-Source Histological Segmentation Software Open
In the era of digitalization, the biomedical sector has been affected by the spread of artificial intelligence. In recent years, the possibility of using deep and machine learning methods for clinical diagnostic and therapeutic interventio…
View article: Editorial: Radiomics and radiogenomics in genitourinary oncology: artificial intelligence and deep learning applications
Editorial: Radiomics and radiogenomics in genitourinary oncology: artificial intelligence and deep learning applications Open
EDITORIAL article Front. Radiol., 18 December 2023Sec. Artificial Intelligence in Radiology Volume 3 - 2023 | https://doi.org/10.3389/fradi.2023.1325594
View article: A Critical Analysis of the Robustness of Radiomics to Variations in Segmentation Methods in 18F-PSMA-1007 PET Images of Patients Affected by Prostate Cancer
A Critical Analysis of the Robustness of Radiomics to Variations in Segmentation Methods in 18F-PSMA-1007 PET Images of Patients Affected by Prostate Cancer Open
Background: Radiomics shows promising results in supporting the clinical decision process, and much effort has been put into its standardization, thus leading to the Imaging Biomarker Standardization Initiative (IBSI), that established how…
View article: Radiomics Analyses to Predict Histopathology in Patients with Metastatic Testicular Germ Cell Tumors before Post-Chemotherapy Retroperitoneal Lymph Node Dissection
Radiomics Analyses to Predict Histopathology in Patients with Metastatic Testicular Germ Cell Tumors before Post-Chemotherapy Retroperitoneal Lymph Node Dissection Open
Background: The identification of histopathology in metastatic non-seminomatous testicular germ cell tumors (TGCT) before post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) holds significant potential to reduce treatment-re…
View article: Artificial Intelligence for Classifying the Relationship between Impacted Third Molar and Mandibular Canal on Panoramic Radiographs
Artificial Intelligence for Classifying the Relationship between Impacted Third Molar and Mandibular Canal on Panoramic Radiographs Open
The purpose of this investigation was to evaluate the diagnostic performance of two convolutional neural networks (CNNs), namely ResNet-152 and VGG-19, in analyzing, on panoramic images, the rapport that exists between the lower third mola…
View article: An Overview of In Vitro Assays of 64Cu-, 68Ga-, 125I-, and 99mTc-Labelled Radiopharmaceuticals Using Radiometric Counters in the Era of Radiotheranostics
An Overview of In Vitro Assays of 64Cu-, 68Ga-, 125I-, and 99mTc-Labelled Radiopharmaceuticals Using Radiometric Counters in the Era of Radiotheranostics Open
Radionuclides are unstable isotopes that mainly emit alpha (α), beta (β) or gamma (γ) radiation through radiation decay. Therefore, they are used in the biomedical field to label biomolecules or drugs for diagnostic imaging applications, s…
View article: Phenotyping the Histopathological Subtypes of Non-Small-Cell Lung Carcinoma: How Beneficial Is Radiomics?
Phenotyping the Histopathological Subtypes of Non-Small-Cell Lung Carcinoma: How Beneficial Is Radiomics? Open
The aim of this study was to investigate the usefulness of radiomics in the absence of well-defined standard guidelines. Specifically, we extracted radiomics features from multicenter computed tomography (CT) images to differentiate betwee…
View article: Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays
Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays Open
Polyphenols have gained widespread attention as they are effective in the prevention and management of various diseases, including cancer diseases (CD) and rheumatoid arthritis (RA). They are natural organic substances present in fruits, v…