Albert Dahdah
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View article: β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction
β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction Open
Neutrophils play a crucial role in instigating inflammation as well as its resolution post-myocardial infarction (MI). Although granulopoiesis in the bone marrow (BM) is the major source of cardiac neutrophils post-MI, infiltration of neut…
View article: Cigarette smoke aggravates atherosclerosis by promoting the infiltration of inflammasome-primed neutrophils and disrupting macrophage function in lesions
Cigarette smoke aggravates atherosclerosis by promoting the infiltration of inflammasome-primed neutrophils and disrupting macrophage function in lesions Open
Background Cigarette smoking (CS) is a major risk factor for cardiovascular disease (CVD) through chronic inflammation. While its pulmonary effects are well established, the mechanisms linking lung inflammation to vascular injury remain un…
View article: Impact of age and sex on myelopoiesis and inflammation during myocardial infarction
Impact of age and sex on myelopoiesis and inflammation during myocardial infarction Open
View article: Immunological Insights into Cigarette Smoking-Induced Cardiovascular Disease Risk
Immunological Insights into Cigarette Smoking-Induced Cardiovascular Disease Risk Open
Smoking is one of the most prominent addictions of the modern world, and one of the leading preventable causes of death worldwide. Although the number of tobacco smokers is believed to be at a historic low, electronic cigarette use has bee…
View article: Neutrophil Migratory Patterns: Implications for Cardiovascular Disease
Neutrophil Migratory Patterns: Implications for Cardiovascular Disease Open
The body’s inflammatory response involves a series of processes that are necessary for the immune system to mitigate threats from invading pathogens. Leukocyte migration is a crucial process in both homeostatic and inflammatory states. The…
View article: Neutrophils in cardiovascular disease: warmongers, peacemakers, or both?
Neutrophils in cardiovascular disease: warmongers, peacemakers, or both? Open
Neutrophils, the most abundant of all leucocytes and the first cells to arrive at the sites of sterile inflammation/injury act as a double-edged sword. On one hand, they inflict a significant collateral damage to the tissues and on the oth…
View article: Oxidative Stress in Neutrophils: Implications for Diabetic Cardiovascular Complications
Oxidative Stress in Neutrophils: Implications for Diabetic Cardiovascular Complications Open
Significance: Neutrophil behavior and function are altered by hyperglycemia associated with diabetes. Aberrant activation by hyperglycemia causes neutrophils to respond with increased production of reactive oxidative species …
View article: A Novel Syngeneic Immunocompetent Mouse Model of Head and Neck Cancer Pain Independent of Interleukin-1 Signaling
A Novel Syngeneic Immunocompetent Mouse Model of Head and Neck Cancer Pain Independent of Interleukin-1 Signaling Open
BACKGROUND: Pain is one of the first presenting symptoms in patients with head and neck cancer, who often develop chronic and debilitating pain as the disease progresses. Pain is also an important prognostic marker for survival. Unfortunat…
View article: Table of Contents
Table of Contents Open
View article: Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis
Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis Open
Objective— Dyslipidemia is a component of the metabolic syndrome, an established risk factor for atherosclerotic cardiovascular disease, and is also observed in various autoimmune and chronic inflammatory conditions. However, there are lim…