Albert Gjedde
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View article: Interrelations between dopaminergic-, gabaergic- and glutamatergic neurotransmitters in antipsychotic-naïve psychosis patients and the association to initial treatment response
Interrelations between dopaminergic-, gabaergic- and glutamatergic neurotransmitters in antipsychotic-naïve psychosis patients and the association to initial treatment response Open
Preclinical evidence points to disturbances in neural networks in psychosis involving interrelations between dopaminergic-, GABAergic- and glutamatergic neurotransmitter systems. In support, we have previously shown that aberrant interrela…
View article: Embracing Scientific Debate in Brain Metabolism
Embracing Scientific Debate in Brain Metabolism Open
Brain metabolism is a fascinating and exciting research topic. Many new metabolic features of the brain continue to be unveiled and much remains to be discovered. To truly enable scientific progress, it is imperative that discoveries and t…
View article: Kinetics of the amino acid uptake tracer O-(2-[18F]fluoroethyl)-L-tyrosine (FET) in human brain
Kinetics of the amino acid uptake tracer O-(2-[18F]fluoroethyl)-L-tyrosine (FET) in human brain Open
Compartmental analysis results for [18F]FET uptake in extra-tumoral human brain regions are in accord with the few prior reports, mainly obtained in experimental animals, and support the use of single frame quantitation. Present findings i…
View article: Interrelations Between Dopaminergic-, GABAergic- and Glutamatergic Neurotransmitters in Antipsychotic-Naïve Psychosis Patients and the Association to Initial Treatment Response
Interrelations Between Dopaminergic-, GABAergic- and Glutamatergic Neurotransmitters in Antipsychotic-Naïve Psychosis Patients and the Association to Initial Treatment Response Open
Preclinical evidence points to disturbances in neural networks in psychosis involving interrelations between dopaminergic-, GABAergic- and glutamatergic neurotransmitter systems. In support, we have previously shown that aberrant interrela…
View article: Acute transcutaneous auricular vagus nerve stimulation modulates presynaptic <scp>SV2A</scp> density in healthy rat brain: An in vivo <scp>microPET</scp> study
Acute transcutaneous auricular vagus nerve stimulation modulates presynaptic <span>SV2A</span> density in healthy rat brain: An in vivo <span>microPET</span> study Open
Vagus nerve stimulation (VNS) is the subject of exploration as an adjunct treatment for neurological disorders such as epilepsy, chronic migraine, pain, and depression. A non‐invasive form of VNS is transcutaneous auricular VNS (taVNS). Co…
View article: Relation of Insulin Resistance to Brain Glucose Metabolism in Fasting and Hyperinsulinemic States: A Systematic Review and Meta-analysis
Relation of Insulin Resistance to Brain Glucose Metabolism in Fasting and Hyperinsulinemic States: A Systematic Review and Meta-analysis Open
Context Abnormal brain glucose metabolism may cause cognitive disease in type 2 diabetes, yet the relation between insulin resistance and brain glucose metabolism has not been systematically described. Objective We evaluated the impact of …
View article: Regulation of mitochondrial dysfunction by estrogens and estrogen receptors in Alzheimer’s disease: A focused review
Regulation of mitochondrial dysfunction by estrogens and estrogen receptors in Alzheimer’s disease: A focused review Open
Alzheimer’s disease (AD) is a neurodegenerative disorder that primarily manifests itself by progressive memory loss and cognitive decline, thus significantly affecting memory functions and quality of life. The canonical amyloid-β hypothesi…
View article: Regulation of mitochondrial dysfunction by estrogens and estrogen receptors in Alzheimer's disease: A focused review
Regulation of mitochondrial dysfunction by estrogens and estrogen receptors in Alzheimer's disease: A focused review Open
Alzheimer's disease (AD) is a neurodegenerative disorder that primarily manifests itself by progressive memory loss and cognitive decline, thus significantly affecting memory functions and quality of life. In this review, we proceed from t…
View article: Dr. Sean Marrett (1960 - 2023): A Life of Joyful Engagement
Dr. Sean Marrett (1960 - 2023): A Life of Joyful Engagement Open
Dr. Sean Marrett, a treasured neuroscientist and highly engaged member of the international brain mapping community for more than three decades, passed away on December 12, 2023 after a 16 month battle with Mesothelioma. His impact went be…
View article: EEG Frequency Correlates with α2-Receptor Density in Parkinson’s Disease
EEG Frequency Correlates with α2-Receptor Density in Parkinson’s Disease Open
Introduction: Increased theta and delta power and decreased alpha and beta power, measured with quantitative electroencephalography (EEG), have been demonstrated to have utility for predicting the development of dementia in patients with P…
View article: In Ischemic Heart Disease, Reduced Sensitivity to Pressure at the Sternum Accompanies Lower Mortality after Five Years: Evidence from a Randomized Controlled Trial
In Ischemic Heart Disease, Reduced Sensitivity to Pressure at the Sternum Accompanies Lower Mortality after Five Years: Evidence from a Randomized Controlled Trial Open
Background: Autonomic nervous system dysfunction (ANSD) is associated with negative prognosis of ischemic heart disease (IHD). Elevated periosteal pressure sensitivity (PPS) at the sternum relates to ANSD and sympathetic hyperactivity. Two…
View article: Novel approach to depression in ischemic heart disease: attenuation of autonomic dysfunction lowers depression scores
Novel approach to depression in ischemic heart disease: attenuation of autonomic dysfunction lowers depression scores Open
Introduction Depression in ischemic heart disease (IHD) is associated with increased mortality, and autonomic nervous system dysfunction (ANSD) may link the two conditions. Regulatory functions of the autonomic nervous system with respect …
View article: Editorial: Nicotine and its derivatives in disorders of cognition: a challenging new topic of study
Editorial: Nicotine and its derivatives in disorders of cognition: a challenging new topic of study Open
EDITORIAL article Front. Neurosci., 18 July 2023Sec. Neurodegeneration Volume 17 - 2023 | https://doi.org/10.3389/fnins.2023.1252705
View article: In Type 2 Diabetes Mellitus, normalization of hemoglobin A1c accompanies reduced sensitivity to pressure at the sternum
In Type 2 Diabetes Mellitus, normalization of hemoglobin A1c accompanies reduced sensitivity to pressure at the sternum Open
Background The autonomic nervous system (ANS) maintains glucose homeostasis. While higher than normal glucose levels stimulate the ANS toward reduction, previous findings suggest an association between sensitivity to, or pain from, pressur…
View article: A single dose of cocaine raises SV2A density in hippocampus of adolescent rats
A single dose of cocaine raises SV2A density in hippocampus of adolescent rats Open
Objective Cocaine is a highly addictive psychostimulant that affects synaptic activity with structural and functional adaptations of neurons. The transmembrane synaptic vesicle glycoprotein 2A (SV2A) of pre-synaptic vesicles is commonly us…
View article: Transient equilibrium determination of dopamine D2/D3 receptor densities and affinities in brain
Transient equilibrium determination of dopamine D2/D3 receptor densities and affinities in brain Open
Long-term alteration of dopaminergic neurotransmission is known to modulate the D 2 /D 3 receptor expression in the brain. The modulation can occur as a response to pathological processes or pharmacological intervention. The receptor densi…
View article: Four decades of mapping and quantifying neuroreceptors at work in vivo by positron emission tomography
Four decades of mapping and quantifying neuroreceptors at work in vivo by positron emission tomography Open
Decryption of brain images is the basis for the necessary translation of the findings from imaging to information required to meet the demands of clinical intervention. Tools of brain imaging, therefore, must satisfy the conditions dictate…
View article: Dopamine D 2/3 receptor availabilities in striatal and extrastriatal regions of the adult human brain: Comparison of four methods of analysis
Dopamine D 2/3 receptor availabilities in striatal and extrastriatal regions of the adult human brain: Comparison of four methods of analysis Open
Background: Values of binding potentials ( BP ND ) of dopamine D 2/3 receptors differ in different regions of the brain, but we do not know with certainty how much of this difference is due either to different receptor numbers, or to diffe…
View article: Relationship between manual dexterity and left-right asymmetry of anatomical and functional properties of corticofugal tracts revealed by T2-weighted brain images
Relationship between manual dexterity and left-right asymmetry of anatomical and functional properties of corticofugal tracts revealed by T2-weighted brain images Open
The corticofugal tracts (CFT) are key agents of upper limb motor function. Although the tracts form high-intensity regions relative to surrounding tissue in T2-weighted magnetic resonance images (T2WI), the precise relations of signal inte…
View article: In Alzheimer's disease, amyloid beta accumulation is a protective mechanism that ultimately fails
In Alzheimer's disease, amyloid beta accumulation is a protective mechanism that ultimately fails Open
Hypothesis and predictions Here, we claim that amyloid beta (Aβ) accumulation is a protective mechanism that ultimately fails. We predict that more Aβ accumulates in regions with higher rates of glucose metabolism, reaching a maximum follo…
View article: Asymmetry of signal intensities of corticofugal tracts in T2-weighted brain images reflects manual dexterity
Asymmetry of signal intensities of corticofugal tracts in T2-weighted brain images reflects manual dexterity Open
The corticofugal tracts (CFT) are key agents of upper limb motor function. Although the tracts form high-intensity regions relative to surrounding tissue in T2-weighted magnetic resonance images (T2WI), the precise relations of signal inte…
View article: Synaptic Vesicle Glycoprotein 2A: Features and Functions
Synaptic Vesicle Glycoprotein 2A: Features and Functions Open
In recent years, the field of neuroimaging dramatically moved forward by means of the expeditious development of specific radioligands of novel targets. Among these targets, the synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane pr…
View article: On the learning of addictive behavior: Sensation-seeking propensity predicts dopamine turnover in dorsal striatum
On the learning of addictive behavior: Sensation-seeking propensity predicts dopamine turnover in dorsal striatum Open
We asked if sensation-seeking is linked to premorbid personality characteristics in patients with addictive disorders, or the characteristics follow the sensation-seeking activity. We interpreted the former as a state associated with norma…
View article: Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure
Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure Open
Exposure to moderate hypoxia in humans leads to cerebral lactate production, which occurs even when the cerebral metabolic rate of oxygen (CMRO2) is unaffected. We searched for the mechanism of this lactate production by testing the hypoth…