Albert Hofman
YOU?
Author Swipe
View article: The rapid growth in Mendelian randomization studies
The rapid growth in Mendelian randomization studies Open
View article: Compression of cognitive decline and cognitive resilience in extreme longevity
Compression of cognitive decline and cognitive resilience in extreme longevity Open
BACKGROUND Compressing the duration of cognitive impairment is critical to preserve quality of life until the end. To what extent cognitive decline is compressed and cognitive resilience increases with extreme longevity is not well underst…
View article: Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study
Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study Open
View article: Sounding “All in One Voice”
Sounding “All in One Voice” Open
What performative strategies do choir members encapsulate in the phrase “all in one voice”? In its sonic materiality, “all in one voice” is a dynamic social and vocal interaction between musically trained or “talented” and “untalented” sin…
View article: Closing the gap in dementia research by community-based cohort studies in the Chinese population
Closing the gap in dementia research by community-based cohort studies in the Chinese population Open
View article: Impaired baroreflex sensitivity and long‐term risk of dementia in community‐based older adults
Impaired baroreflex sensitivity and long‐term risk of dementia in community‐based older adults Open
Background Hypertension is an important modifiable risk factor for dementia, but the role of blood pressure (BP) in the development of dementia is not fully understood. Emerging data links increased BP variability and abnormal BP dynamics …
View article: Long term effects of preventive activities of youth health care in The Netherlands: results of a four-part study
Long term effects of preventive activities of youth health care in The Netherlands: results of a four-part study Open
Background. In this article the results are presented of a four part study on the effect of screening for scoliosis and (repeated) well-care visits and freely accessible consultation hours at secondary schools, on the incidence and prevale…
View article: ASSOCIATION BETWEEN BLOOD PRESSURE VARIABILITY WITH DEMENTIA AND COGNITIVE IMPAIRMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS
ASSOCIATION BETWEEN BLOOD PRESSURE VARIABILITY WITH DEMENTIA AND COGNITIVE IMPAIRMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS Open
View article: Chance, ignorance, and the paradoxes of cancer: Richard Peto on developing preventative strategies under uncertainty
Chance, ignorance, and the paradoxes of cancer: Richard Peto on developing preventative strategies under uncertainty Open
View article: A note of thanks
A note of thanks Open
View article: The Swiss Brain Health Plan 2023–2033
The Swiss Brain Health Plan 2023–2033 Open
The brain and its health are essential for our (physical mental, social, and spiritual) wellbeing, for being able to realize our potential as individuals, and also for a fair, well-functioning, and productive society. However, today the wo…
View article: Orthostatic Blood Pressure Change, Dizziness, and Risk of Dementia in the ARIC Study
Orthostatic Blood Pressure Change, Dizziness, and Risk of Dementia in the ARIC Study Open
BACKGROUND: Abnormal orthostatic blood pressure (BP) regulation may result in cerebral hypoperfusion and brain ischemia and contribute to dementia. It may also manifest as early symptoms of the neurodegenerative process associated with dem…
View article: GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification Open
Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show t…
View article: Issue Information
Issue Information Open
Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries.
View article: Supplementary Table 2 and Supplemental Figures from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
Supplementary Table 2 and Supplemental Figures from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations Open
Table S2: Odds ratio and 95% confidence limits for cancers associated with variants with pleiotropic associations. Figure S1: Flowchart showing analysis steps. Figure S2. Manhattan plots by chromosome for individual cancer sites. Figure S3…
View article: Data from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
Data from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations Open
Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal …
View article: Data from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
Data from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations Open
Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal …
View article: Supplementary Table 2 and Supplemental Figures from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
Supplementary Table 2 and Supplemental Figures from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations Open
Table S2: Odds ratio and 95% confidence limits for cancers associated with variants with pleiotropic associations. Figure S1: Flowchart showing analysis steps. Figure S2. Manhattan plots by chromosome for individual cancer sites. Figure S3…
View article: Supplementary Table 1 from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
Supplementary Table 1 from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations Open
Variants selected for replication
View article: Supplementary Table 1 from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
Supplementary Table 1 from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations Open
Variants selected for replication
View article: Structural Brain Differences in the Alzheimer's Disease Continuum: Insights into the Heterogeneity from a Large Multi-Site Neuroimaging Consortium
Structural Brain Differences in the Alzheimer's Disease Continuum: Insights into the Heterogeneity from a Large Multi-Site Neuroimaging Consortium Open
View article: A note of thanks
A note of thanks Open
View article: Miettinen revisited: Causal and preventive interdependence. Elementary principles. Scan J Work Environ Health 1982;8:168
Miettinen revisited: Causal and preventive interdependence. Elementary principles. Scan J Work Environ Health 1982;8:168 Open
View article: In Memoriam: Olli S. Miettinen (1936-2021)
In Memoriam: Olli S. Miettinen (1936-2021) Open
View article: Plasma amyloid-β40 in relation to subclinical atherosclerosis and cardiovascular disease: A population-based study
Plasma amyloid-β40 in relation to subclinical atherosclerosis and cardiovascular disease: A population-based study Open
View article: A note of thanks
A note of thanks Open
View article: Biological Aging for Risk Prediction of First-Ever Intracerebral Hemorrhage and Cerebral Infarction in Advanced Age
Biological Aging for Risk Prediction of First-Ever Intracerebral Hemorrhage and Cerebral Infarction in Advanced Age Open
Successful interventions to prevent cerebrovascular disease and stroke require early identification of persons at risk before clinical manifestation of disease. We assessed the predictive value of biological age (BA) as an early indicator …
View article: Dementia Risk Following Ischemic Stroke: A Systematic Review and Meta-Analysis of Factors Collected at Time of Stroke Diagnosis
Dementia Risk Following Ischemic Stroke: A Systematic Review and Meta-Analysis of Factors Collected at Time of Stroke Diagnosis Open
Objective To assess incidence rates and predictors of dementia after ischemic stroke. Methods A search was conducted on Embase and Medline for reports published up to November 2019. Studies were included if they: 1) assessed dementia incid…
View article: Longitudinal Body Weight Change, Visit-To-Visit Body Weight Fluctuation, and Cognitive Decline Among Older Adults
Longitudinal Body Weight Change, Visit-To-Visit Body Weight Fluctuation, and Cognitive Decline Among Older Adults Open
Background: The evidence regarding dementia and late-life weight change is inconsistent, and data on body weight fluctuation and dementia are limited. Objective: To test the hypothesis that weight loss and substantial weight fluctuation pr…
View article: Association Between Blood Pressure Variability With Dementia and Cognitive Impairment: A Systematic Review and Meta-Analysis
Association Between Blood Pressure Variability With Dementia and Cognitive Impairment: A Systematic Review and Meta-Analysis Open
Research links high blood pressure variability (BPV) with stroke and cerebrovascular disease, however, its association with cognition remains unclear. Moreover, it remains uncertain which BP-derived parameter (ie, variability or mean) hold…