Albert Stanek
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View article: SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center
SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center Open
B cell tolerance prevents autoimmunity by deleting or deactivating autoreactive B cells that otherwise may cause autoantibody-driven disorders, including systemic lupus erythematosus (lupus). Lupus is characterized by immunoglobulin Gs car…
View article: Role of regenerating islet-derived proteins in inflammatory bowel disease
Role of regenerating islet-derived proteins in inflammatory bowel disease Open
Inflammatory bowel disease (IBD) is an inflammatory disorder of the gastrointestinal tract that affects millions of patients worldwide. It has a complex and multifactorial etiology leading to excessive exposure of intestinal epithelium to …
View article: Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis
Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis Open
Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is…