Albert Sufianov
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Translational Relevance of SCA1 Models for the Development of Therapies for Spinocerebellar Ataxia Type 1 Open
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative dis-ease caused by the expansion of cytosine–adenine–guanine (CAG) repeats in the ataxin-1 (ATXN1) gene, leading to toxic gain-of-function of the ataxin-1 (ATX…
Intraventricular Endoscopic Surgery for Pediatric Hypothalamic Hamartomas: Surgical Series and Literature Meta-Analysis Open
Endoscopic procedures for HH are a safe option for children, as they demonstrate a high level of success in controlling epilepsy and low rates of complications. Thulium-laser disconnection could represent an attractive tool for disconnecti…
View article: A stereoencephalography study of internal speech
A stereoencephalography study of internal speech Open
With advances in intracranial recording techniques, converting speech-related brain activity into commands for brain-computer interfaces (BCIs) is becoming increasingly feasible. In this study, we explored the utility of stereoencephalogra…
View article: AAV-Based Gene Therapy: Opportunities, Risks, and Scale-Up Strategies
AAV-Based Gene Therapy: Opportunities, Risks, and Scale-Up Strategies Open
Currently, the development of adeno-associated virus (AAV)-based gene therapy is a promising method for treating various diseases and is gaining increasing popularity. However, the use of AAV has certain drawbacks and faces limitations suc…
View article: Neutralizing Antibodies: Role in Immune Response and Viral Vector Based Gene Therapy
Neutralizing Antibodies: Role in Immune Response and Viral Vector Based Gene Therapy Open
Neutralizing antibodies (nAbs) are an important component of the immune system, which plays a dual role in modern medicine. On the one hand, they significantly limit the effectiveness of gene therapy based on viral vectors, reducing the ef…
Microsurgical clipping of aneurysms of the right middle cerebral artery bifurcation, ophthalmic segment of right internal carotid artery using of MIPLATTA approach: a video case report Open
Microsurgical clipping of aneurysms of the bifurcation of the middle cerebral artery (MCA) and the ophthalmic segment of the internal carotid artery (ICA) requires precise access and minimization of the risk of damage to structures. This v…
Efficacy of decompressive hemicraniectomy supplemented by infarctectomy and tentoriotomy in surgical treatment of malignant middle cerebral artery infarction: a case series Open
Objective: The study aimed to assess the efficacy of decompressive hemicraniectomy supplemented by resection of the ischemic anterior temporal lobe and tentoriotomy in the treatment of malignant cerebral infarction (MCI) in the middle cere…
lncRNAs and circRNAs: Emerging Players in Pediatric Medulloblastoma Pathology Open
Medulloblastomas (MBs) are the most common malignant brain tumors in children, marked by aggressive growth, molecular heterogeneity, and a high propensity for cerebrospinal dissemination. Despite advancements in conventional treatments - s…
View article: Looking to the Future of Viral Vectors in Ocular Gene Therapy: Clinical Review
Looking to the Future of Viral Vectors in Ocular Gene Therapy: Clinical Review Open
Eye diseases can significantly affect the quality of life of patients due to decreased visual acuity. Although modern ophthalmological diagnostic methods exist, some diseases of the visual system are asymptomatic in the early stages. Most …
THERAPY, DIAGNOSTICS AND HEMATOLOGY FOR CANINE BABESIOSIS Open
Babesiosis (piroplasmosis, babesiosis) is an acute invasive disease of animals, characterized by intoxication, fever, development of anemia and severe progressive course. Babesiosis refers to transmissible parasitic zoonotic infections and…
Peripheral nerve sheath tumors associated with neurofibromatosis type 1 Open
Neurofibromatosis type 1 is a hereditary disorder characterized by cutaneous and plexiform neurofibromas. Plexiform neurofibroma is a tumor, involving multiple nerve fascicles, which are surrounded by the perineurium. The tumors look like …
Novel Approach for Solving an Assignment Problem using Brute Force Method Open
This paper applies the Brute Force method to the Assignment Problem to minimize total man-Hours. By generating and evaluating all possible task assignments, we effectively find the optimal solution, demonstrating the method’s capability in…
Machine learning algorithm to predict in-hospital mortality after aneurysmal subarachnoid hemorrhage Open
Machine learning (ML) methodology surpasses the traditional tools of statistical analysis in processing big data clinical datasets . Aim. To develop an ML algorithm of application of recurrent neural network to analyze clinical datasets of…
View article: Adeno-Associated Viral Vectors in the Treatment of Epilepsy
Adeno-Associated Viral Vectors in the Treatment of Epilepsy Open
Epilepsy is a brain disorder characterized by a persistent predisposition to epileptic seizures. With various etiologies of epilepsy, a significant proportion of patients develop pharmacoresistance to antiepileptic drugs, which necessitate…
The Severity of Myelopathy as a Diagnostic and Prognostic Indicator in the Treatment of Patients with Cervical Spinal Stenosis Open
Cervical spinal stenosis is accompanied by dysfunction of the spinal cord, leading to numerous complications and disability of patients. These issues are well known to radiologists, vertebrologists, and neurosurgeons, however, not all of m…
View article: Adeno-Associated Viral Vectors in the Treatment of Epilepsy
Adeno-Associated Viral Vectors in the Treatment of Epilepsy Open
Epilepsy is a brain disease characterized by a persistent predisposition to epileptic seizures. The current issue is the development of new methods of epilepsy therapy, In particular, using gene therapy methods. Promising areas of research…
View article: Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases
Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases Open
Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer’s, Parkinson’s, Huntington’s disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities of patie…
View article: Challenging assumptions: “unveiling meritocracy’s reality in neurosurgery”
Challenging assumptions: “unveiling meritocracy’s reality in neurosurgery” Open
Introduction Meritocracy, a concept revered as the cornerstone of fairness and equal opportunity, is critically examined in the context of neurosurgery. This article challenges the notion that success in this demanding field is solely dete…
MSCT-semiotics of vertebrae in patients with cervical spine stenosis Open
Introduction The number of surgical interventions on the cervical spine for stenosis has been constantly increasing. This fact proves that there is a need for careful preoperative preparation that would consider the complexity of the inter…
Percutaneous thermal radiofrequency rhizotomy of L2–S1 spinal nerve roots in children with cerebral palsy Open
OBJECTIVE This study presents the results of an evaluation of the effectiveness of percutaneous thermal radiofrequency (RF) ablation of spinal nerve roots to reduce spasticity and improve motor function in children with cerebral palsy (CP)…
Low-Cost 3D Models for Cervical Spine Tumor Removal Training for Neurosurgery Residents Open
Background and Objectives: Spinal surgery, particularly for cervical pathologies such as myelopathy and radiculopathy, requires a blend of theoretical knowledge and practical skill. The complexity of these conditions, often necessitating s…
Endoscopic Treatment of Deep Gluteal Syndrome: 3-Portal Technique Open
We describe all-endoscopic deep gluteal syndrome treatment and sciatic nerve decompression at the infrapiriformis space. Surgery is performed with the patient in the prone position with the usual arthroscopic instruments and pump. The firs…
View article: Towards a multimodal brain-computer interface: intracranial recordings in humans performing speech and handwriting tasks.
Towards a multimodal brain-computer interface: intracranial recordings in humans performing speech and handwriting tasks. Open
While it is known that the same brain area could be involved in multiple functions, such multimodality has yet to be utilized in applications like brain-computer interfaces (BCI). For instance, could the same BCI decode both hand movements…
Comparative analysis of the methods of an all-endoscopic brachial plexus decompression and a mini-invasive endoscopically-assisted technique for management of patients with traumatic brachioplexopathy Open
Introduction As reported, brachioplexopathy is a relevant polyetiological disease with an annual incidence from 0.17 to 1.6 per 100,000. There are two basic endoscopic methods of brachial plexus decompression: an endoscopically-assisted mi…
Endoscopically Assisted Exoscopic Surgery for Microvascular Decompression of the Trigeminal Nerve with Intraoperative Use of Indocyanine Green Open
Trigeminal neuralgia (TN) is a chronic condition that is typically caused by a blood vessel exerting pressure on the V cranial nerve at the root entry zone. The gold standard for TN treatment is microvascular decompression (MVD). This illu…