Jon A. Tsai
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View article: Eradicating Drug-tolerant Persister Cells in <i>EGFR-</i> Mutated Non–Small Cell Lung Cancer by Targeting TROP2 with CAR-T Cellular Therapy
Eradicating Drug-tolerant Persister Cells in <i>EGFR-</i> Mutated Non–Small Cell Lung Cancer by Targeting TROP2 with CAR-T Cellular Therapy Open
EGFR tyrosine kinase inhibitors have dramatically improved outcomes for patients with EGFR-mutated non–small cell lung cancer (NSCLC), but relapse frequently occurs because of drug-tolerant persister (DTP) cells that can evolve and develop…
View article: 474. SELF EXPANDABLE METAL STENT AS A BRIDGE TO RESECTION IN ESOPHAGEAL CANCER – A NATIONAL REGISTER ANALYSIS ON MORTALITY
474. SELF EXPANDABLE METAL STENT AS A BRIDGE TO RESECTION IN ESOPHAGEAL CANCER – A NATIONAL REGISTER ANALYSIS ON MORTALITY Open
Background Patients with esophageal cancer commonly present with malnutrition and weight loss due to dysphagia. Self Expandable Metal Stent (SEMS) have been used to relieve dysphagia and optimize nutrition prior to surgery and during neoad…
View article: A comparative study of teriflunomide and dimethyl fumarate within the Swedish MS Registry
A comparative study of teriflunomide and dimethyl fumarate within the Swedish MS Registry Open
Background: Teriflunomide and dimethyl fumarate (DMF) are first-line disease-modifying treatments for multiple sclerosis with similar labels that are used in comparable populations. Objectives: The objective of this study was to compare th…
View article: Preoperative detection of sentinel lymph nodes with hybrid SPECT/computed tomography imaging may improve the accuracy of sentinel lymph node biopsies in patients with early stages of cancer of the oesophagus or gastro-oesophageal junction
Preoperative detection of sentinel lymph nodes with hybrid SPECT/computed tomography imaging may improve the accuracy of sentinel lymph node biopsies in patients with early stages of cancer of the oesophagus or gastro-oesophageal junction Open
Objectives The aim of this study was to investigate the sentinel lymph node biopsy (SLNB) method in patients with cancer of the oesophagus or gastro-oesophageal junction (GOJ) guided by preoperative hybrid single-photon emission tomography…
View article: Nationwide study of the impact of D2 lymphadenectomy on survival after gastric cancer surgery
Nationwide study of the impact of D2 lymphadenectomy on survival after gastric cancer surgery Open
Background Gastrectomy including D2 lymphadenectomy is regarded as the standard curative treatment for advanced gastric cancer in Asia. This procedure has also been adopted gradually in the West, despite lack of support from RCTs. This stu…
View article: Blood neurofilament light levels segregate treatment effects in multiple sclerosis
Blood neurofilament light levels segregate treatment effects in multiple sclerosis Open
Choice of DMT in RRMS is significantly associated with degree of reduction in pNfL, which supports a role for pNfL as a drug response marker.
View article: Extent of lymphadenectomy has no impact on postoperative complications after gastric cancer surgery in Sweden
Extent of lymphadenectomy has no impact on postoperative complications after gastric cancer surgery in Sweden Open
The majority of gastric cancer resections in Sweden have included only a limited lymphadenectomy (D0 and D1). More extensive lymphadenectomy (D1+/D2) seemed to have no impact on postoperative morbidity or mortality.
View article: Treatment of esophageal anastomotic leakage with self-expanding metal stents: analysis of risk factors for treatment failure
Treatment of esophageal anastomotic leakage with self-expanding metal stents: analysis of risk factors for treatment failure Open
Stent treatment for esophageal anastomotic leakage is successful in the majority of cases. Continuous leakage after initial stent insertion, decreased physical performance preoperatively, and the development of an esophagotracheal fistula …