Albert Vallejo-Gracia
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View article: SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein
SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein Open
SARS-CoV-2 non-structural protein Nsp14 is a highly conserved enzyme necessary for viral replication. Nsp14 forms a stable complex with non-structural protein Nsp10 and exhibits exoribonuclease and N7-methyltransferase activities. Protein-…
View article: Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19
Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19 Open
The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We uti…
View article: Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19
Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19 Open
The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We uti…
View article: Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA
Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA Open
A hallmark of coronavirus transcription is the generation of negative-sense RNA intermediates that serve as the templates for the synthesis of positive-sense genomic RNA (gRNA) and an array of subgenomic mRNAs (sgRNAs) encompassing sequenc…
View article: Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2
Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2 Open
The exact mechanism of coronavirus replication and transcription is not fully understood; however, a hallmark of coronavirus transcription is the generation of negative-sense RNA intermediates that serve as the templates for the synthesis …
View article: Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19
Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19 Open
The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We uti…
View article: FOXO1 promotes HIV latency by suppressing ER stress in T cells
FOXO1 promotes HIV latency by suppressing ER stress in T cells Open
View article: FOXO1 promotes HIV Latency by suppressing ER stress in T cells
FOXO1 promotes HIV Latency by suppressing ER stress in T cells Open
Quiescence is a hallmark of CD4 + T cells latently infected with HIV-1. While reversing this quiescence is an effective approach to reactivate latent HIV from T cells in culture, it can cause deleterious cytokine dysregulation in patients.…
View article: PKC Activation Induces Ubiquitination-Dependent KV1.3 Endocytosis Mediated by Nedd4-2 Ubiquitin Ligase
PKC Activation Induces Ubiquitination-Dependent KV1.3 Endocytosis Mediated by Nedd4-2 Ubiquitin Ligase Open
View article: Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation
Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation Open
The voltage-dependent potassium channel Kv1.3 plays essential physiological functions in the immune system. Kv1.3, regulating the membrane potential, facilitates downstream Ca 2+ -dependent pathways and becomes concentrated in specific mem…
View article: The C-Terminal Domain of Kv1.3 Interacts with KCNE4 to form Oligomeric Channels
The C-Terminal Domain of Kv1.3 Interacts with KCNE4 to form Oligomeric Channels Open