Albert H.C. Wong
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View article: 609 | REAL‐WORLD TREATMENT PATTERNS, CLINICAL OUTCOMES AND BURDEN OF ILLNESS OF AUTOLOGOUS STEM‐CELL TRANSPLANT INELIGIBLE PATIENTS WITH MANTLE CELL LYMPHOMA IN ONTARIO, CANADA
609 | REAL‐WORLD TREATMENT PATTERNS, CLINICAL OUTCOMES AND BURDEN OF ILLNESS OF AUTOLOGOUS STEM‐CELL TRANSPLANT INELIGIBLE PATIENTS WITH MANTLE CELL LYMPHOMA IN ONTARIO, CANADA Open
View article: Characterizing suicidal thoughts and behaviours in individuals presenting to a psychiatric emergency department: a protocol for a multimethod approach for suicide prevention research
Characterizing suicidal thoughts and behaviours in individuals presenting to a psychiatric emergency department: a protocol for a multimethod approach for suicide prevention research Open
Introduction Identifying individuals at risk of suicide remains an ongoing challenge. Previous research investigating risk factors for suicidal thoughts and behaviours (STB) has been informative for assessing suicide risk. However, the com…
View article: Sex and Age Differences in Glucocorticoid Signaling After an Aversive Experience in Mice
Sex and Age Differences in Glucocorticoid Signaling After an Aversive Experience in Mice Open
Background: glucocorticoids may play an important role in the formation of fear memory, which is relevant to the neurobiology of post-traumatic stress disorder (PTSD). In our previous study, we showed the glucocorticoid receptor (GR) forms…
View article: Patterns of overeating in middle-aged Chinese from Hong Kong
Patterns of overeating in middle-aged Chinese from Hong Kong Open
Background Obesity is one of the most important risk factors for non-communicable diseases worldwide. Overweightness may be attributable to a wide spectrum of overeating behaviours. However, the various types of overeating behaviors are un…
View article: Small-molecule targeting AMPA-mediated excitotoxicity has therapeutic effects in mouse models for multiple sclerosis
Small-molecule targeting AMPA-mediated excitotoxicity has therapeutic effects in mouse models for multiple sclerosis Open
While most research and treatments for multiple sclerosis (MS) focus on autoimmune reactions causing demyelination, it is possible that neurodegeneration precedes the autoimmune response. Hence, glutamate receptor antagonists preventing ex…
View article: Care Pathways and Initial Engagement in Early Psychosis Intervention Services Among Youths and Young Adults
Care Pathways and Initial Engagement in Early Psychosis Intervention Services Among Youths and Young Adults Open
Importance Broad efforts to improve access to early psychosis intervention (EPI) services may not address health disparities in pathways to care and initial engagement in treatment. Objective To understand factors associated with referral …
View article: Fasting Prior to Coronary Procedures, a Thing of the Past: A Retrospective Audit
Fasting Prior to Coronary Procedures, a Thing of the Past: A Retrospective Audit Open
View article: Evaluating the effect of electroconvulsive therapy (ECT) on post-traumatic stress disorder (PTSD): A systematic review and meta-analysis of five studies
Evaluating the effect of electroconvulsive therapy (ECT) on post-traumatic stress disorder (PTSD): A systematic review and meta-analysis of five studies Open
ECT has been proposed as a potential treatment for PTSD. There is a small number of clinical studies to date, but no quantitative review of the efficacy has been conducted. We performed a systematic review and meta-analysis to evaluate the…
View article: Serum amyloid P component (SAP) modulates antidepressant effects through promoting membrane insertion of the serotonin transporter
Serum amyloid P component (SAP) modulates antidepressant effects through promoting membrane insertion of the serotonin transporter Open
View article: Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice
Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice Open
View article: The Eph receptor A4 plays a role in demyelination and depression-related behavior
The Eph receptor A4 plays a role in demyelination and depression-related behavior Open
became aware that an incorrect panel was used for Figure 3N.In addition, the molecular weight markers in Figure 9C
View article: The D2R-DISC1 protein complex and associated proteins are altered in schizophrenia and normalized with antipsychotic treatment
The D2R-DISC1 protein complex and associated proteins are altered in schizophrenia and normalized with antipsychotic treatment Open
Background For decades, the dopamine D2 receptor (D2R) has been known as the main target of antipsychotic medications, but the mechanism for antipsychotic effects beyond this pharmacological target remains unclear. Disrupted-in-schizophren…
View article: Serum amyloid P component level is associated with clinical response to escitalopram treatment in patients with major depressive disorder
Serum amyloid P component level is associated with clinical response to escitalopram treatment in patients with major depressive disorder Open
Serum amyloid P component (SAP) is a universal constituent of human amyloid deposits, which has been implicated in Alzheimer's disease and major depressive disorder (MDD). However, the relationship between SAP level and depression severity…
View article: Sex Differences in Dopamine Receptor Signaling in Fmr1 Knockout Mice: A Pilot Study
Sex Differences in Dopamine Receptor Signaling in Fmr1 Knockout Mice: A Pilot Study Open
Fragile X syndrome (FXS) is an X-chromosome-linked dominant genetic disorder that causes a variable degree of cognitive dysfunction and developmental disability. Current treatment is symptomatic and no existing medications target the speci…
View article: Disrupting the α7nAChR–NR2A protein complex exerts antidepressant-like effects
Disrupting the α7nAChR–NR2A protein complex exerts antidepressant-like effects Open
View article: The Impact of COVID-19 on Psychiatric Emergency and Inpatient Services in the First Month of the Pandemic in a Large Urban Mental Health Hospital in Ontario, Canada
The Impact of COVID-19 on Psychiatric Emergency and Inpatient Services in the First Month of the Pandemic in a Large Urban Mental Health Hospital in Ontario, Canada Open
The World Health Organization characterized COVID-19 (coronavirus disease 2019) as a pandemic on March 11, 2020 (WHO). Within a couple of days, all Canadian provinces announced the implementation of social distancing measures. We evaluated…
View article: Electroconvulsive therapy with a memory reactivation intervention for post-traumatic stress disorder: A randomized controlled trial
Electroconvulsive therapy with a memory reactivation intervention for post-traumatic stress disorder: A randomized controlled trial Open
NCT04027452.
View article: ED to EPI: protocol for a pragmatic randomised controlled trial of an SMS (text) messaging intervention to improve the transition from the emergency department to early psychosis intervention for young people with psychosis
ED to EPI: protocol for a pragmatic randomised controlled trial of an SMS (text) messaging intervention to improve the transition from the emergency department to early psychosis intervention for young people with psychosis Open
Introduction While nearly half of all new psychotic disorders are diagnosed in the emergency department (ED), most young people who present to the ED with psychosis do not receive timely follow-up with a psychiatrist, and even fewer with e…
View article: Electroconvulsive Therapy with a Memory Reactivation Intervention for Post-Traumatic Stress Disorder: A Randomized Controlled Trial
Electroconvulsive Therapy with a Memory Reactivation Intervention for Post-Traumatic Stress Disorder: A Randomized Controlled Trial Open
Introduction Post-traumatic Stress Disorder (PTSD) often does not respond to available treatments. Memories are vulnerable to disruption during reconsolidation, and electroconvulsive therapy (ECT) has amnestic effects. We sought to exploit…
View article: Bioactive Chemical Composition of Cannabis Extracts and Cannabinoid Receptors
Bioactive Chemical Composition of Cannabis Extracts and Cannabinoid Receptors Open
Cannabis is widely used as a therapeutic drug, especially by patients suffering from psychiatric and neurodegenerative diseases. However, the complex interplay between phytocannabinoids and their targets in the human receptome remains larg…
View article: The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity
The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity Open
View article: Correction to: CpG‑creating mutations are costly in many human viruses
Correction to: CpG‑creating mutations are costly in many human viruses Open
View article: CpG-creating mutations are costly in many human viruses
CpG-creating mutations are costly in many human viruses Open
View article: The glucocorticoid receptor–FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder
The glucocorticoid receptor–FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder Open
Posttraumatic stress disorder (PTSD) can develop after exposure to severe psychological trauma, leaving patients with disabling anxiety, nightmares, and flashbacks. Current treatments are only partially effective, and development of better…
View article: Magnetic seizure therapy (MST) for major depressive disorder
Magnetic seizure therapy (MST) for major depressive disorder Open
View article: CpG-creating Mutations are Costly in Many Human Viruses
CpG-creating Mutations are Costly in Many Human Viruses Open
Mutations can occur throughout the virus genome and may be beneficial or deleterious. We are interested in mutations that yield a C next to a G, producing CpG sites. CpG sites are rare in eukaryotic and viral genomes. For the eukaryotes, i…
View article: Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease
Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease Open
View article: Additional file 2: of Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease
Additional file 2: of Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease Open
Oscillation parameters for all interrogated CpG positions. EVC p value, cosinor p value, mesor, acrophase, amplitude, and genomic information for all interrogated cytosine positions. (CSV 40045 kb)
View article: Additional file 4: of Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease
Additional file 4: of Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease Open
MEME output for oscillating cytosines in neutrophil. Motif enrichment logos and characteristics for the sequences within 100 bp of osc-modCs. Generated using the MEME software tool. (HTML 2357 kb)
View article: Additional file 1: of Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease
Additional file 1: of Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease Open
Oscillation parameters of white blood cell fractions. Counts, fractions, and oscillation p values of 5 WBC cell types averaged across 4 individuals. (XLSX 9 kb)