Alberto Boveris
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View article: Free radical chemistry in biological systems
Free radical chemistry in biological systems Open
Mitochondria are an active source of the free radical superoxide (O2-) and nitric oxide (NO), whose production accounts for about 2% and 0.5% respectively, of mitochondrial O2 uptake under physiological conditions. Superoxide is produced b…
View article: Complex I syndrome in striatum and frontal cortex in a rat model of Parkinson disease
Complex I syndrome in striatum and frontal cortex in a rat model of Parkinson disease Open
Mitochondrial dysfunction named complex I syndrome was observed in striatum mitochondria of rotenone treated rats (2 mg rotenone/kg, i. p., for 30 or 60 days) in an animal model of Parkinson disease. After 60 days of rotenone treatment, th…
View article: (+)-Catechin inhibits heart mitochondrial complex I and nitric oxide synthase: functional consequences on membrane potential and hydrogen peroxide production
(+)-Catechin inhibits heart mitochondrial complex I and nitric oxide synthase: functional consequences on membrane potential and hydrogen peroxide production Open
The aim was to study thein vitroeffect of nM to low μM concentration of (+)-catechin on the enzymatic activities of mitochondrial complex I and mtNOS, as well as the consequences on the membrane potential and H2O2prod…
View article: Mitochondrial peroxynitrite generation is mainly driven by superoxide steady-state concentration rather than by nitric oxide steady-state concentration
Mitochondrial peroxynitrite generation is mainly driven by superoxide steady-state concentration rather than by nitric oxide steady-state concentration Open
\n\tIn biological systems, ONOO- production depends on production rates of NO and O2-, and on the reactions of these two free radicals with other biological components, which limit the local concentrations of NO and O2-. In mitochondria, …
View article: Rat liver mitochondrial dysfunction by addition of copper(II) or iron(III) ions
Rat liver mitochondrial dysfunction by addition of copper(II) or iron(III) ions Open
View article: Superoxide and hydrogen peroxide productions by NO-inhibited complex III
Superoxide and hydrogen peroxide productions by NO-inhibited complex III Open
Complex III plays a central role in the mitochondrial respiratory chain transferring electrons from ubiquinol to cytochrome c and pumping protons to the intermembrane space, contributing to the protonmotive force. Furtherm... | Find, read …
View article: Heart mitochondrial dysfunction in diabetic rats
Heart mitochondrial dysfunction in diabetic rats Open
Diabetic cardiomyopathy, i.e. the ventricular dysfunction in the absence of hypertension or coronary arterial disease, is a common complication of diabetes mellitus that leads to a heightened risk of heart failure and death among diabetic …
View article: Nitric oxide metabolism in heart mitochondria
Nitric oxide metabolism in heart mitochondria Open
Normal cardiac function is accomplished through a continuous energy supply provided by mitochondria. Heart mitochondria are the major source of reactive oxygen and nitrogen species: superoxide anion (O2-) and nitric oxide (NO). NO producti…