Alberto Cassetta
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View article: Structural flexibility of the human vault protein revealed by high-resolution cryo-EM and molecular dynamics simulations
Structural flexibility of the human vault protein revealed by high-resolution cryo-EM and molecular dynamics simulations Open
Vaults are massive ribonucleoprotein complexes, highly conserved and abundant in eukaryotic cells, yet with unclear function. Their thin-walled barrel-shape architecture is composed of two symmetrical, antiparallel half-shells, each contai…
View article: Unveiling the Solvent Effect: DMSO Interaction with Human Nerve Growth Factor and Its Implications for Drug Discovery
Unveiling the Solvent Effect: DMSO Interaction with Human Nerve Growth Factor and Its Implications for Drug Discovery Open
Background: The Nerve Growth Factor (NGF) is essential for neuronal survival and function and represents a key therapeutic target for pain and inflammation-related disorders, as well as for neurodegenerative diseases. Small-molecule antago…
View article: Live cell optical super-resolution microscopy of dystroglycan mutants as a model for dystroglycanopathies in multiple cell lines
Live cell optical super-resolution microscopy of dystroglycan mutants as a model for dystroglycanopathies in multiple cell lines Open
Introduction Dystroglycan (DG) is an adhesion complex comprising two subunits, α-DG and β-DG, which interact non-covalently at the plasma membrane. As a component of the dystrophin-glycoprotein complex DGC, DG plays a crucial role in linki…
View article: On the Cholesterol Raising Effect of Coffee Diterpenes Cafestol and 16-O-Methylcafestol: Interaction with Farnesoid X Receptor
On the Cholesterol Raising Effect of Coffee Diterpenes Cafestol and 16-O-Methylcafestol: Interaction with Farnesoid X Receptor Open
The diterpene cafestol represents the most potent cholesterol-elevating compound known in the human diet, being responsible for more than 80% of the effect of coffee on serum lipids, with a mechanism still not fully clarified. In the prese…
View article: Structural basis for specific inhibition of salicylate synthase from Mycobacterium abscessus
Structural basis for specific inhibition of salicylate synthase from Mycobacterium abscessus Open
Blocking iron uptake and metabolism has been emerging as a promising therapeutic strategy for the development of novel antimicrobial compounds. Like all mycobacteria, M. abscessus (Mab) has evolved several countermeasures to scavenge iron …
View article: Targeting Siderophore-Mediated Iron Uptake in M. abscessus: A New Strategy to Limit the Virulence of Non-Tuberculous Mycobacteria
Targeting Siderophore-Mediated Iron Uptake in M. abscessus: A New Strategy to Limit the Virulence of Non-Tuberculous Mycobacteria Open
Targeting pathogenic mechanisms, rather than essential processes, represents a very attractive approach for the development of new antimycobacterial drugs. In this context, iron acquisition routes have recently emerged as potentially drugg…
View article: Distinct conformational changes occur within the intrinsically unstructured pro‐domain of <scp>pro‐Nerve</scp> Growth Factor in the presence of <scp>ATP</scp> and Mg<sup>2+</sup>
Distinct conformational changes occur within the intrinsically unstructured pro‐domain of <span>pro‐Nerve</span> Growth Factor in the presence of <span>ATP</span> and Mg<sup>2+</sup> Open
Nerve growth factor (NGF), the prototypical neurotrophic factor, is involved in the maintenance and growth of specific neuronal populations, whereas its precursor, proNGF, is involved in neuronal apoptosis. Binding of NGF or proNGF to TrkA…
View article: CCDC 2181402: Experimental Crystal Structure Determination
CCDC 2181402: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis, Structure, and Characterization of 4,4′-(Anthracene-9,10-diylbis(ethyne-2,1-diyl))bis(1-methyl-1-pyridinium) Bismuth Iodide (C<sub>30</sub>H<sub>22</sub>N<sub>2</sub>)<sub>3</sub>Bi<sub>4</sub>I<sub>18</sub>, an Air, Water, and Thermally Stable 0D Hybrid Perovskite with High Photoluminescence Efficiency
Synthesis, Structure, and Characterization of 4,4′-(Anthracene-9,10-diylbis(ethyne-2,1-diyl))bis(1-methyl-1-pyridinium) Bismuth Iodide (C<sub>30</sub>H<sub>22</sub>N<sub>2</sub>)<sub>3</sub>Bi<sub>4</sub>I<sub>18</sub>, an Air, Water, and Thermally Stable 0D Hybrid Perovskite with High Photoluminescence Efficiency Open
4,4'-(Anthracene-9,10-diylbis(ethyne-2,1-diyl))bis(1-methyl-1-pyridinium) bismuth iodide (C30H22N2)3Bi4I18 (AEPyBiI) was obtained as a black powder by a very simple route by mixing an acetone solution of BiI3 and an aqueous solution of C30…
View article: Unveiling the binding mode of perfluorooctanoic acid to human serum albumin
Unveiling the binding mode of perfluorooctanoic acid to human serum albumin Open
Perfluorooctanoic acid (PFOA) is a toxic compound that is absorbed and distributed throughout the body by noncovalent binding to serum proteins such as human serum albumin (hSA). Though the interaction between PFOA and hSA has been already…
View article: CCDC 1894399: Experimental Crystal Structure Determination
CCDC 1894399: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Calibration of rotation axes for multi-axis goniometers in macromolecular crystallography
Calibration of rotation axes for multi-axis goniometers in macromolecular crystallography Open
The installation of multi-axis goniometers such as the ESRF/EMBL miniKappa goniometer system has allowed the increased use of sample reorientation in macromolecular crystallography. Old and newly appearing data collection methods require p…
View article: Influence of substrate on molecular order for self‐assembled adlayers of CoPc and FePc
Influence of substrate on molecular order for self‐assembled adlayers of CoPc and FePc Open
Self‐assembled metal phthalocyanine thin films are receiving considerable interest due to their potential technological applications. In this study, we present a comprehensive study of CoPc and FePc thin films of about 50 nm thickness on t…
View article: Cover Image, Volume 39, Issue 2
Cover Image, Volume 39, Issue 2 Open
On the cover: This cover image, by Giulia Signorino et al., is based on the Research Article A dystroglycan mutation (p.Cys667Phe) associated to muscle-eye-brain disease with multicystic leucodystrophy results in ER-retention of the mutant…
View article: A dystroglycan mutation (p.Cys667Phe) associated to muscle-eye-brain disease with multicystic leucodystrophy results in ER-retention of the mutant protein
A dystroglycan mutation (p.Cys667Phe) associated to muscle-eye-brain disease with multicystic leucodystrophy results in ER-retention of the mutant protein Open
Dystroglycan (DG) is a cell adhesion complex composed by two subunits, the highly glycosylated α-DG and the transmembrane β-DG. In skeletal muscle, DG is involved in dystroglycanopathies, a group of heterogeneous muscular dystrophies chara…
View article: The effect of the pathological V72I, D109N and T190M missense mutations on the molecular structure of α-dystroglycan
The effect of the pathological V72I, D109N and T190M missense mutations on the molecular structure of α-dystroglycan Open
Dystroglycan (DG) is a highly glycosylated protein complex that links the cytoskeleton with the extracellular matrix, mediating fundamental physiological functions such as mechanical stability of tissues, matrix organization and cell polar…
View article: Structural flexibility of human α‐dystroglycan
Structural flexibility of human α‐dystroglycan Open
Dystroglycan ( DG ), composed of α and β subunits, belongs to the dystrophin‐associated glycoprotein complex. α‐ DG is an extracellular matrix protein that undergoes a complex post‐translational glycosylation process. The bifunctional glyc…