Alberto Lázaro
YOU?
Author Swipe
View article: Mesenchymal stem cells-like as a prognostic biomarker in patients diagnosed with acute myeloid leukemia
Mesenchymal stem cells-like as a prognostic biomarker in patients diagnosed with acute myeloid leukemia Open
The bone marrow microenvironment influences acute myeloid leukemia (AML) progression. Mesenchymal stem cell-like (MSC-l) populations may exert tumor-modulating effects, but their prognostic role remains uncertain. We retrospectively analyz…
View article: Influence of the type of volatile anesthetic on the development of acute kidney injury after endovascular repair of aortic aneurysm: a randomized controlled trial (DESEVAR study)
Influence of the type of volatile anesthetic on the development of acute kidney injury after endovascular repair of aortic aneurysm: a randomized controlled trial (DESEVAR study) Open
Acute kidney injury (AKI) frequently occurs after endovascular aortic aneurysm repair (EVAR), leading to significant morbidity and mortality. It is associated with contrast administration, hypovolemia, arterial microembolization due to ren…
View article: Intraocular pressure values in the Iberian Peninsula: epidemiological study and influencing factors
Intraocular pressure values in the Iberian Peninsula: epidemiological study and influencing factors Open
Intraocular pressure increases with age, and among the variables studied, high blood pressure and family history of glaucoma were the most important risk factors.
View article: Cilastatin Modulates DPEP1- and IQGAP1-Associated Neuro-Glio-Vascular Inflammation in Oxaliplatin-Induced Peripheral Neurotoxicity
Cilastatin Modulates DPEP1- and IQGAP1-Associated Neuro-Glio-Vascular Inflammation in Oxaliplatin-Induced Peripheral Neurotoxicity Open
Oxaliplatin-induced peripheral neurotoxicity (OIPN) represents a major challenge in cancer therapy, characterized by dorsal root ganglia (DRG) inflammation and disruption of neuro-glio-vascular unit function. In this study, we investigated…
View article: Cilastatin Attenuates Acute Kidney Injury and Reduces Mortality in a Rat Model of Sepsis
Cilastatin Attenuates Acute Kidney Injury and Reduces Mortality in a Rat Model of Sepsis Open
Sepsis is a life-threatening condition caused by an abnormal host response to infection, leading to organ dysfunction and potentially death. Acute kidney injury (AKI) is a critical complication of sepsis. Various pathways, especially signa…
View article: Mesenchymal stem cells-like as a prognostic biomarker in patients diagnosed with acute myeloid leukemia
Mesenchymal stem cells-like as a prognostic biomarker in patients diagnosed with acute myeloid leukemia Open
The bone marrow (BM) microenvironment plays a pivotal role in acute myeloid leukemia (AML) progression. Among its components, mesenchymal stem cells (MSCs) can exhibit tumor-modulating properties, yet their precise prognostic significance …
View article: Changes in AmotL2 Expression in Cells of the Human Enteral Nervous System in Oxaliplatin-Induced Enteric Neuropathy
Changes in AmotL2 Expression in Cells of the Human Enteral Nervous System in Oxaliplatin-Induced Enteric Neuropathy Open
Gastrointestinal (GI) toxicity is a common side effect in patients undergoing oxaliplatin (OxPt)-based chemotherapy for colorectal cancer (CRC). Frequently, this complication persists in the long term and could affect the efficacy of the t…
View article: Untargeted metabolomics analysis of serum and urine unveils the protective effect of cilastatin on altered metabolic pathways during cisplatin-induced acute kidney injury
Untargeted metabolomics analysis of serum and urine unveils the protective effect of cilastatin on altered metabolic pathways during cisplatin-induced acute kidney injury Open
Acute kidney injury (AKI) is one of the most serious complications of cisplatin anticancer therapies. Cilastatin is a highly promising nephroprotective agent to eventually enter clinical use, but its biochemical mechanism is still not full…
View article: Tubular biomarkers and histology in lupus nephritis
Tubular biomarkers and histology in lupus nephritis Open
Introduction The relevance of tubulo‐interstitial involvement for kidney prognosis has recently been emphasized, but validated biomarkers for predicting histology are still lacking. The aim of our study was to evaluate different serum and …
View article: #57 Tubular biomarkers in proteinuric kidney diseases
#57 Tubular biomarkers in proteinuric kidney diseases Open
Background and Aims Proteinuria is not only a biomarker of chronic kidney disease (CKD) and a risk predictor of adverse outcomes but also a driver of kidney disease progression. The excessive filtration of plasma proteins through the glome…
View article: Tubular biomarkers in proteinuric kidney disease: histology correlation and kidney prognosis of tubular biomarkers
Tubular biomarkers in proteinuric kidney disease: histology correlation and kidney prognosis of tubular biomarkers Open
Background Proteinuria is not only a biomarker of chronic kidney disease (CKD) but also a driver of CKD progression. The aim of this study was to evaluate serum and urinary tubular biomarkers in patients with biopsied proteinuric kidney di…
View article: Biomarkers in Contrast-Induced Acute Kidney Injury: Towards A New Perspective
Biomarkers in Contrast-Induced Acute Kidney Injury: Towards A New Perspective Open
Contrast-Induced Acute Kidney Injury (CI-AKI) remains a frequent iatrogenic condition since radiological procedures using intra-vascular iodinated contrast media (CM) are being widely administered for diagnostic and therapeutic purposes. D…
View article: Cilastatin as a Potential Anti-Inflammatory and Neuroprotective Treatment in the Management of Glaucoma
Cilastatin as a Potential Anti-Inflammatory and Neuroprotective Treatment in the Management of Glaucoma Open
Glaucoma is a neurodegenerative disease that causes blindness. In this study, we aimed to evaluate the protective role of cilastatin (CIL), generally used in the treatment of nephropathologies associated with inflammation, in an experiment…
View article: Biomarkers in Contrast-Induced Acute Kidney Injury: Towards a new perspective.
Biomarkers in Contrast-Induced Acute Kidney Injury: Towards a new perspective. Open
Contrast-Induced Acute Kidney Injury (CI-AKI) remains a frequent iatrogenic condition since radiological procedures using intra-vascular iodinated contrast media (CM) are being widely administered for diagnostic and therapeutic purposes. D…
View article: #3587 INTERMITENT RECURRENT HYPONATREMIA: A NEW EXPERIMENTAL MODEL – A STUDY ON ITS EFFECTS ON WATER BALANCE AND CENTRAL NERVOUS SYSTEM
#3587 INTERMITENT RECURRENT HYPONATREMIA: A NEW EXPERIMENTAL MODEL – A STUDY ON ITS EFFECTS ON WATER BALANCE AND CENTRAL NERVOUS SYSTEM Open
Background and Aims Hyponatremia is the most common electrolyte disturbance in clinical care. Even mild presentations are associated with poor prognosis and increased mortality, in spite of which there is a trend to minimize the importance…
View article: #5852 EFFECT OF DIET ON THE COLLECTOR DUCT BEHAVIOUR: RELEVANCE IN PRECLINICAL DRUG DEVELOPMENT
#5852 EFFECT OF DIET ON THE COLLECTOR DUCT BEHAVIOUR: RELEVANCE IN PRECLINICAL DRUG DEVELOPMENT Open
Background and Aims Drug induced syndrome of inadequate antidiuretic hormone secretion (SIADH) is a common problem in clinical practice. Early detection of this side effect at a preclinical level would improve safety and efficiency. We inv…
View article: Novel Experimental Mouse Model to Study Malaria-Associated Acute Kidney Injury
Novel Experimental Mouse Model to Study Malaria-Associated Acute Kidney Injury Open
The impact of malaria-associated acute kidney injury (MAKI), one of the strongest predictors of death in children with severe malaria (SM), has been largely underestimated and research in this area has been neglected. Consequently, a stand…
View article: Immune response and reactogenicity after immunization with two-doses of an experimental COVID-19 vaccine (CVnCOV) followed by a third-fourth shot with a standard mRNA vaccine (BNT162b2): RescueVacs multicenter cohort study
Immune response and reactogenicity after immunization with two-doses of an experimental COVID-19 vaccine (CVnCOV) followed by a third-fourth shot with a standard mRNA vaccine (BNT162b2): RescueVacs multicenter cohort study Open
Partly funded by the Institute of Health Carlos-III and COVID-19 Fund, co-financed by the European Regional Development Fund (FEDER) "A way to make Europe".
View article: FKBP51, AmotL2 and IQGAP1 Involvement in Cilastatin Prevention of Cisplatin-Induced Tubular Nephrotoxicity in Rats
FKBP51, AmotL2 and IQGAP1 Involvement in Cilastatin Prevention of Cisplatin-Induced Tubular Nephrotoxicity in Rats Open
The immunophilin FKBP51, the angiomotin AmotL2, and the scaffoldin IQGAP1 are overexpressed in many types of cancer, with the highest increase in leucocytes from patients undergoing oxaliplatin chemotherapy. Inflammation is involved in the…
View article: Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats
Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats Open
Sepsis increases glucocorticoid and decreases IGF-1, leading to skeletal muscle wasting and cachexia. Muscle atrophy mainly takes place in locomotor muscles rather than in respiratory ones. Our study aimed to elucidate the mechanism respon…
View article: Lipidomics Reveals Cisplatin-Induced Renal Lipid Alterations during Acute Kidney Injury and Their Attenuation by Cilastatin
Lipidomics Reveals Cisplatin-Induced Renal Lipid Alterations during Acute Kidney Injury and Their Attenuation by Cilastatin Open
Nephrotoxicity is a major complication of cisplatin-based chemotherapy, leading to acute kidney injury in ca. 30% of patients, with no preventive intervention or treatment available for clinical use. Cilastatin has proved to exert a nephro…
View article: Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy
Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy Open
Cisplatin is one of the most widely used chemotherapeutic agents in oncology, although its nephrotoxicity limits application and dosage. We present the results of a clinical study on prophylaxis of cisplatin-induced nephrotoxicity in patie…
View article: Nephroprotective Effect of Cilastatin against Gentamicin-Induced Renal Injury In Vitro and In Vivo without Altering Its Bactericidal Efficiency
Nephroprotective Effect of Cilastatin against Gentamicin-Induced Renal Injury In Vitro and In Vivo without Altering Its Bactericidal Efficiency Open
Gentamicin is a used antibiotic that causes nephrotoxicity in 10–20% of treatment periods, which limits its use considerably. Our results have shown that cilastatin may be a promising therapeutic alternative in toxin-induced acute kidney i…
View article: Cilastatin: a potential treatment strategy against COVID-19 that may decrease viral replication and protect from the cytokine storm
Cilastatin: a potential treatment strategy against COVID-19 that may decrease viral replication and protect from the cytokine storm Open
Acute kidney injury (AKI) is a frequent secondary feature in coronavirus disease 2019 patients [1].AKI may require renal replacement therapy, complicates management and is associated with impaired outcomes.The absence of current drug treat…
View article: Urinary excretion of parathyroid hormone-related protein correlates with renal function in control rats and rats with cisplatin nephrotoxicity
Urinary excretion of parathyroid hormone-related protein correlates with renal function in control rats and rats with cisplatin nephrotoxicity Open
Parathyroid hormone-related protein (PTHrP) and its receptor are abundantly expressed throughout the renal parenchyma, where PTHrP exerts a modulatory action on renal function. PTHrP upregulation is a common event associated with the mecha…
View article: Correction: Cisplatin-Induced Non-Oliguric Acute Kidney Injury in a Pediatric Experimental Animal Model in Piglets
Correction: Cisplatin-Induced Non-Oliguric Acute Kidney Injury in a Pediatric Experimental Animal Model in Piglets Open
[This corrects the article DOI: 10.1371/journal.pone.0149013.].
View article: Lipid imaging for visualizing cilastatin amelioration of cisplatin-induced nephrotoxicity
Lipid imaging for visualizing cilastatin amelioration of cisplatin-induced nephrotoxicity Open
Nephrotoxicity is a major limitation to cisplatin antitumor therapies. Cilastatin, an inhibitor of renal dehydropeptidase-I, was recently proposed as a promising nephroprotector against cisplatin toxicity, preventing apoptotic cell death. …
View article: Impact of Altered Intestinal Microbiota on Chronic Kidney Disease Progression
Impact of Altered Intestinal Microbiota on Chronic Kidney Disease Progression Open
In chronic kidney disease (CKD), accumulation of uremic toxins is associated with an increased risk of CKD progression. Some uremic toxins result from nutrient processing by gut microbiota, yielding precursors of uremic toxins or uremic to…