Alberto Ravarino
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View article: Lessons from autopsy: Topographical variability of atherosclerosis plaques
Lessons from autopsy: Topographical variability of atherosclerosis plaques Open
Atherosclerosis is a complex disease characterized by the accumulation of plaques in arterial walls. Understanding its pathogenesis remains incomplete, with factors like inflammation, oxidative stress, and hypertension playing critical rol…
View article: Ultrastructural findings of lung injury due to Vaccine-induced Immune Thrombotic Thrombo- cytopenia (VITT) following COVID-19 vaccination: a scanning electron microscopic study.
Ultrastructural findings of lung injury due to Vaccine-induced Immune Thrombotic Thrombo- cytopenia (VITT) following COVID-19 vaccination: a scanning electron microscopic study. Open
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare new syndrome occurring after the ChAdOx1 nCoV-19 vaccine immunization. Patients with VITT are characterized by a variable clinical presentation, likewise also the outcome …
View article: Inter‐observer agreement for the histological diagnosis of invasive lobular breast carcinoma
Inter‐observer agreement for the histological diagnosis of invasive lobular breast carcinoma Open
Invasive lobular breast carcinoma (ILC) is the second most common breast carcinoma (BC) subtype and is mainly driven by loss of E‐cadherin expression. Correct classification of BC as ILC is important for patient treatment. This study asses…
View article: SOFT TISSUE EPITHELIOID VASCULAR TUMORS: A PRACTICAL CLINICO PATHOLOGICAL DIAGNOSTIC APPROACH
SOFT TISSUE EPITHELIOID VASCULAR TUMORS: A PRACTICAL CLINICO PATHOLOGICAL DIAGNOSTIC APPROACH Open
Key histologic and immnohistochemical features for a correct diagnosis of vascular epithelioid tumors.
View article: Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury
Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury Open
Zinc is the second most abundant trace element in the human body, and it plays a fundamental role in human physiology, being an integral component of hundreds of enzymes and transcription factors. The discovery that zinc atoms may compete …
View article: Vaccine-induced severe thrombotic thrombocytopenia following COVID-19 vaccination: a report of an autoptic case and review of the literature.
Vaccine-induced severe thrombotic thrombocytopenia following COVID-19 vaccination: a report of an autoptic case and review of the literature. Open
In our patient, the majority of data necessary for a VITT final diagnosis were present: thrombocytopenia and thrombosis in pulmonary, portal, hepatic, renal and mesenteric veins, associated with a marked increase of D-dimer serum levels. T…
View article: Immunohistochemical findings in the lungs of COVID-19 subjects: evidence of surfactant dysregulation.
Immunohistochemical findings in the lungs of COVID-19 subjects: evidence of surfactant dysregulation. Open
Our immunohistochemical data show the dysregulation of surfactant production in COVID-19 patients, particularly regarding SP-A expression. The increased presence of SP-A in condensed masses inside alveolar spaces could invalidate the thera…
View article: Metabolomic Analysis of Plasma from Breast Tumour Patients. A Pilot Study
Metabolomic Analysis of Plasma from Breast Tumour Patients. A Pilot Study Open
Background Patients at risk of breast cancer are submitted to mammography, resulting in a classification of the lesions following the Breast Imaging Reporting and Data System (BI-RADS®). Due to BI-RADS 3 classification problems and the gre…
View article: Trace elements and the carotid plaque: the GOOD (Mg, Zn, Se), the UGLY (Fe, Cu), and the BAD (P, Ca)?
Trace elements and the carotid plaque: the GOOD (Mg, Zn, Se), the UGLY (Fe, Cu), and the BAD (P, Ca)? Open
Multiple epidemiological studies have suggested that industrialization and progressive urbanization should be considered one of the main factors responsible for the rising of atherosclerosis in the developing world. In this scenario, the r…
View article: Placental Calcification Score: a new semiquantitative method to assess pattern and grading of placental calcifications
Placental Calcification Score: a new semiquantitative method to assess pattern and grading of placental calcifications Open
The relationship between placental calcifications and pregnancy outcome is still controversial. In this study, we examined the occurrence of placental calcifications, and we proposed a histopathological score system, Placental Calcificatio…
View article: Stem/progenitor cells in the developing human cerebellum: an immunohistochemical study
Stem/progenitor cells in the developing human cerebellum: an immunohistochemical study Open
The aim of this study was to analyze, by immunohistochemistry, the occurrence of stem/progenitor cells localized in the different niches of the developing human cerebellum. To this end, cerebellar samples were obtained from 3 fetuses and 3…
View article: The small intestinal mucosa and its stem cells
The small intestinal mucosa and its stem cells Open
In the first part of this review a brief summary of the embryology and histology of the gastrointestinal tract is provided. In the second part intestinal stem cells (ISCs) are discussed. Several signaling pathways play a crucial role in th…
View article: Introduction to embryonic and adult neural stem cells: from the metabolic circuits of the niches to the metabolome
Introduction to embryonic and adult neural stem cells: from the metabolic circuits of the niches to the metabolome Open
Metabolomics has provided new insight into the biology that drives the phenotype of stem cells. During the recent years, metabolic circuits of embryonic and neural stem cells (NSCs) have been better elucidated. Many factors contribute to s…
View article: Stem/progenitor cells in the cerebral cortex of the human preterm: a resource for an endogenous regenerative neuronal medicine?
Stem/progenitor cells in the cerebral cortex of the human preterm: a resource for an endogenous regenerative neuronal medicine? Open
The development of the central nervous system represents a very delicate period of embryogenesis. Premature interruption of neurogenesis in human preterm newborns can lead to motor deficits, including cerebral palsy, and significant cognit…
View article: Immunohistochemical markers of neural progenitor cells in the early embryonic human cerebral cortex
Immunohistochemical markers of neural progenitor cells in the early embryonic human cerebral cortex Open
The development of the human central nervous system represents a delicate moment of embryogenesis. The purpose of this study was to analyze the expression of multiple immunohistochemical markers in the stem/progenitor cells in the human ce…