Albertomaria Moro
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View article: Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages
Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages Open
Tissue resident macrophages are largely of embryonic (fetal liver) origin and long-lived, while bone marrow-derived macrophages (BMDM) are recruited following an acute perturbation, such as hypoxia in the setting of myocardial ischemia. Pr…
View article: A double-negative gene regulatory circuit underlies the virgin behavioral state
A double-negative gene regulatory circuit underlies the virgin behavioral state Open
Virgin females of many species conduct distinctive behaviors, compared with post-mated and/or pregnant individuals. In Drosophila, this post-mating switch is initiated by seminal factors, implying that the default female state is virgin. H…
View article: Distinct Hypoxia-induced Translational Profiles of Embryonic and Adult-derived Macrophages
Distinct Hypoxia-induced Translational Profiles of Embryonic and Adult-derived Macrophages Open
Summary Tissue homeostasis and repair are orchestrated by resident and newly recruited macrophages that alter their gene expression program in response to changes in tissue microenvironment. Embryonic macrophages, such as fetal liver deriv…
View article: A double negative post-transcriptional regulatory circuit underlies the virgin behavioral state
A double negative post-transcriptional regulatory circuit underlies the virgin behavioral state Open
Summary The survival and reproductive success of animals depends on the ability to harmonize their external behaviors with their internal states. For example, females conduct numerous social programs that are distinctive to virgins, compar…
View article: microRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis
microRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis Open
Summary The mechanical properties of tissues, which are determined primarily by their extracellular matrix (ECM), are largely stable over time despite continual turnover of ECM constituents 1,2 . These observations imply active homeostasis…
View article: Identification and dynamic changes of RNAs isolated from RALY-containing ribonucleoprotein complexes
Identification and dynamic changes of RNAs isolated from RALY-containing ribonucleoprotein complexes Open
RALY is a member of the heterogeneous nuclear ribonucleoprotein family (hnRNP), a large family of RNA-binding proteins involved in many aspects of RNA metabolism. Although RALY interactome has been recently characterized, a comprehensive g…