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View article: BASELINE THROMBIN GENERATION TEST DOES NOT PREDICT THROMBOTIC EVENTS IN ACUTE LEUKEMIA: A MONOCENTRIC PROSPECTIVE STUDY
BASELINE THROMBIN GENERATION TEST DOES NOT PREDICT THROMBOTIC EVENTS IN ACUTE LEUKEMIA: A MONOCENTRIC PROSPECTIVE STUDY Open
Thromboembolic and hemorrhagic complications are significant causes of morbidity and mortality in patients with acute leukemias (AL). While AL is characterized by a complex hemostatic imbalance, conventional coagulation tests and platelet …
View article: Kendrick Mass Defect Filtering Enables High-Throughput Untargeted Annotation of Minor Phytocannabinoids: Toward Streamlined Phytocannabinomics
Kendrick Mass Defect Filtering Enables High-Throughput Untargeted Annotation of Minor Phytocannabinoids: Toward Streamlined Phytocannabinomics Open
View article: Comprehensive profiling of sulfated phenolic compounds in edible and infesting seaweeds by a dedicated software-assisted platform
Comprehensive profiling of sulfated phenolic compounds in edible and infesting seaweeds by a dedicated software-assisted platform Open
Seaweeds, comprising green (Chlorophyta), brown (Phaeophyta), and red (Rhodophyta) algae, are recognized as valuable marine resources rich in bioactive phenolic compounds with nutraceutical potential. Despite growing interest in edible spe…
View article: Seaweed (<i>G. gracilis</i>) Protein Hydrolyzates: A Valuable Source of Short- and Medium-Chain Peptides with Multifunctional Properties
Seaweed (<i>G. gracilis</i>) Protein Hydrolyzates: A Valuable Source of Short- and Medium-Chain Peptides with Multifunctional Properties Open
The sustainable valorization of infesting marine biomass offers opportunities to address environmental challenges and emerging nutritional needs. This study investigated the invasive red alga Gracilaria gracilis as a potential sourc…
View article: Recent applications of supercritical fluid chromatography in the analysis of polyphenols
Recent applications of supercritical fluid chromatography in the analysis of polyphenols Open
Polyphenols are a large group of plant secondary metabolites, synthesized mostly through the phenylpropanoid pathway, and they comprise flavonoids, stilbenes, lignans, and simple phenolic acids. The characterization of these natural compou…
View article: The Protein Corona on Nanoparticles for Tumor Targeting in Prostate Cancer—A Review of the Literature and Experimental Trial Protocol
The Protein Corona on Nanoparticles for Tumor Targeting in Prostate Cancer—A Review of the Literature and Experimental Trial Protocol Open
The National Cancer Institute (NCI) recognizes the potential of technologies based on the use of nanoparticles (NPs) in revolutionizing clinical approaches to the diagnosis and prognosis of cancer. Recent research suggests that once NPs co…
View article: Protein Corona on Nanoparticles for Tumor Targeting in Prostate Cancer. Review of the Literature and Experimental Trial Protocol
Protein Corona on Nanoparticles for Tumor Targeting in Prostate Cancer. Review of the Literature and Experimental Trial Protocol Open
The National Cancer Institute (NCI) recognizes the potential of technologies based on the use of nanoparticles (NPs) in revolutionizing clinical approaches in the diagnosis and prognosis of cancer. Recent research suggests that once NPs co…
View article: Structuring lipid nanoparticles, DNA, and protein corona into stealth bionanoarchitectures for in vivo gene delivery
Structuring lipid nanoparticles, DNA, and protein corona into stealth bionanoarchitectures for in vivo gene delivery Open
Lipid nanoparticles (LNPs) play a crucial role in addressing genetic disorders, and cancer, and combating pandemics such as COVID-19 and its variants. Yet, the ability of LNPs to effectively encapsulate large-size DNA molecules remains elu…
View article: Detailed lipid investigation of edible seaweeds by photochemical derivatization and untargeted lipidomics
Detailed lipid investigation of edible seaweeds by photochemical derivatization and untargeted lipidomics Open
Seaweeds are macrophytic algae that have been gaining interest as alternative healthy foods, renewable drug sources, and climate change mitigation agents. In terms of their nutritional value, seaweeds are renowned for their high content of…
View article: Sulfated Bile Acids in Serum as Potential Biomarkers of Disease Severity and Mortality in COVID-19
Sulfated Bile Acids in Serum as Potential Biomarkers of Disease Severity and Mortality in COVID-19 Open
The fight against coronavirus disease 2019 (COVID-19) continues. Since the pandemic’s onset, several biomarkers have been proposed to assess the diagnosis and prognosis of this disease. This research aimed to identify potential disease sev…
View article: Validation of a global method for the simultaneous analysis of polar and non-polar pesticides by online extraction and LC-MS/MS
Validation of a global method for the simultaneous analysis of polar and non-polar pesticides by online extraction and LC-MS/MS Open
The method was validated for 15 pesticides, over the log Kow range from -4.4 to 4.5, using a methodology with single and fast chromatographic separation under conditions compatible with multi-residue analysis by RP-LC-MS/MS. In …
View article: An untargeted analytical workflow based on Kendrick mass defect filtering reveals dysregulations in acylcarnitines in prostate cancer tissue
An untargeted analytical workflow based on Kendrick mass defect filtering reveals dysregulations in acylcarnitines in prostate cancer tissue Open
Hydroxylation of short- and medium-chain minor acylcarnitines appeared to be a significant variable in describing tissue differences, suggesting the hypothesis that the neoplastic growth is linked to oxidation phenomena on selected metabol…
View article: Olive (Olea europaea L.) Seed as New Source of Cholesterol-Lowering Bioactive Peptides: Elucidation of Their Mechanism of Action in HepG2 Cells and Their Trans-Epithelial Transport in Differentiated Caco-2 Cells
Olive (Olea europaea L.) Seed as New Source of Cholesterol-Lowering Bioactive Peptides: Elucidation of Their Mechanism of Action in HepG2 Cells and Their Trans-Epithelial Transport in Differentiated Caco-2 Cells Open
The production of olive oil has important economic repercussions in Mediterranean countries but also a considerable impact on the environment. This production generates enormous quantities of waste and by-products, which can be exploited a…
View article: One-phase extraction coupled with photochemical reaction allows the in-depth lipid characterization of hempseeds by untargeted lipidomics
One-phase extraction coupled with photochemical reaction allows the in-depth lipid characterization of hempseeds by untargeted lipidomics Open
View article: Single Trichome Phytocannabinomics of Two Different Cannabis Varieties
Single Trichome Phytocannabinomics of Two Different Cannabis Varieties Open
View article: Protein corona alleviates adverse biological effects of nanoplastics in breast cancer cells
Protein corona alleviates adverse biological effects of nanoplastics in breast cancer cells Open
Formation and characterization of the protein corona on polystyrene nanoplastics and its impact on cytotoxicity, cellular uptake, and signaling pathways in breast cancer cells.
View article: Ultrasonication coupled to enzymatic hydrolysis of soybean okara proteins for producing bioactive and bioavailable peptides
Ultrasonication coupled to enzymatic hydrolysis of soybean okara proteins for producing bioactive and bioavailable peptides Open
This work was aimed to explore the antioxidative properties, bioavailability and the safety of bioactive peptides obtained by the enzymatic hydrolysis of ultrasound-treated (UO) and untreated (nUO) soybean okara proteins. Particularly, the…
View article: Dispersive solid phase extraction using a hydrophilic molecularly imprinted polymer for the selective extraction of patulin in apple juice samples
Dispersive solid phase extraction using a hydrophilic molecularly imprinted polymer for the selective extraction of patulin in apple juice samples Open
View article: Transformation products of antibacterial drugs in environmental water: Identification approaches based on liquid chromatography-high resolution mass spectrometry
Transformation products of antibacterial drugs in environmental water: Identification approaches based on liquid chromatography-high resolution mass spectrometry Open
In recent years, the presence of antibiotics in the aquatic environment has caused increasing concern for the possible consequences on human health and ecosystems, including the development of antibiotic-resistant bacteria. However, once a…
View article: Bidimensional heart-cut achiral-chiral liquid chromatography coupled to high-resolution mass spectrometry for the separation of the main chiral phytocannabinoids and enantiomerization studies of cannabichromene and cannabichromenic acid
Bidimensional heart-cut achiral-chiral liquid chromatography coupled to high-resolution mass spectrometry for the separation of the main chiral phytocannabinoids and enantiomerization studies of cannabichromene and cannabichromenic acid Open
View article: Untargeted cannabinomics reveals the chemical differentiation of industrial hemp based on the cultivar and the geographical field location
Untargeted cannabinomics reveals the chemical differentiation of industrial hemp based on the cultivar and the geographical field location Open
View article: Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC)
Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC) Open
View article: Occurrence of per- and polyfluorinated alkyl substances in wastewater treatment plants in Northern Italy
Occurrence of per- and polyfluorinated alkyl substances in wastewater treatment plants in Northern Italy Open
Wastewater treatment plants are known to be relevant input sources of per- and polyfluoroalkyl substances (PFAS) in the aquatic environment. This study aimed to investigate the occurrence, fate, and seasonal variability of twenty-five PFAS…
View article: Chemical and biological characterization of the DPP-IV inhibitory activity exerted by lupin (Lupinus angustifolius) peptides: From the bench to the bedside investigation
Chemical and biological characterization of the DPP-IV inhibitory activity exerted by lupin (Lupinus angustifolius) peptides: From the bench to the bedside investigation Open
View article: Kratom: The analytical challenge of an emerging herbal drug
Kratom: The analytical challenge of an emerging herbal drug Open
View article: A green extraction method based on carbon nitride sorbent for the simultaneous determination of free and conjugated estrogens in milk
A green extraction method based on carbon nitride sorbent for the simultaneous determination of free and conjugated estrogens in milk Open
This study proposes a quick and green method based on carbon nitride sorbent to extract six free and five conjugated estrogens from milk samples simultaneously. The adsorption process was studied in detail via adsorption isotherms, while t…
View article: The semisynthetic cannabinoid Hexahydrocannabinol (HHC)
The semisynthetic cannabinoid Hexahydrocannabinol (HHC) Open
Cannabis is a double-faced plant with uncountable therapeutic properties, on one side, and controversial psychotropic activities, on the other side, modulated by CB1 endocannabinoid receptors. Δ 9 -Tetrahydrocannabinol (Δ 9 -THC) has been …
View article: Enantioseparation of chiral phytocannabinoids in medicinal cannabis
Enantioseparation of chiral phytocannabinoids in medicinal cannabis Open
View article: Recent trends in glycoproteomics by characterization of intact glycopeptides
Recent trends in glycoproteomics by characterization of intact glycopeptides Open
This trends article provides an overview of the state of the art in the analysis of intact glycopeptides by proteomics technologies based on LC–MS analysis. A brief description of the main techniques used at the different steps of the anal…
View article: Biotic transformation products of sulfonamides in environmental water samples: High-resolution mass spectrometry-based tentative identification by a suspect screening approach
Biotic transformation products of sulfonamides in environmental water samples: High-resolution mass spectrometry-based tentative identification by a suspect screening approach Open
The presence of pharmaceuticals in the aquatic environment is mainly due to their release from the effluents of the wastewater treatment plants (WWTPs), which are unable to completely remove them and their transformation products (TPs). Su…