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View article: Risk factors for autoimmune liver disease recurrence after liver transplantation
Risk factors for autoimmune liver disease recurrence after liver transplantation Open
BACKGROUND Autoimmune liver disease (AILD) recurrence is common after liver transplantation (LT). While several risk factors for recurrence have been identified, their combined predictive value has yet to be thoroughly investigated. AIM To…
View article: HCV patients with residual fibrosis after DAA treatment re-establish their epigenetic signature after prolonged-release pirfenidone: MINERVA study
HCV patients with residual fibrosis after DAA treatment re-establish their epigenetic signature after prolonged-release pirfenidone: MINERVA study Open
View article: Noninvasive Evaluation of Prolonged‐Release Pirfenidone in Compensated Liver Cirrhosis. <scp>ODISEA</scp> Study, a Randomised Trial
Noninvasive Evaluation of Prolonged‐Release Pirfenidone in Compensated Liver Cirrhosis. <span>ODISEA</span> Study, a Randomised Trial Open
Background Advanced liver fibrosis (ALF) predicts an adverse prognosis in chronic liver disease. In addition to etiological treatment, a new approach to stop or reverse residual fibrosis is desirable. Objective To assess the efficacy and s…
View article: 1146 Obesity/OSA Phenotypes Relative to Hypertension and Diabetes: A Cross-Sectional Study in a Mexican Population
1146 Obesity/OSA Phenotypes Relative to Hypertension and Diabetes: A Cross-Sectional Study in a Mexican Population Open
Introduction A strong association between obstructive sleep apnea (OSA) and obesity has been well documented, however, not all obese OSA patients show similar comorbidities. Two of the most common comorbidities shown by such patients are h…
View article: Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis
Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis Open
Background and aims Quantifying systemic inflammation (SI) in acutely decompensated cirrhosis (ADC) is of major importance because SI is a driver of the most severe forms of ADC, including acute-on-chronic liver failure (ACLF). Blood bioma…
View article: P-78 DECOMPENSATED CIRRHOSIS IN A LARGE MULTINATIONAL COHORT IN LATIN AMERICA: MORTALITY IS TOO HIGH IN THE REGION REGARDLESS OF ETIOLOGY AND COUNTRY
P-78 DECOMPENSATED CIRRHOSIS IN A LARGE MULTINATIONAL COHORT IN LATIN AMERICA: MORTALITY IS TOO HIGH IN THE REGION REGARDLESS OF ETIOLOGY AND COUNTRY Open
Conflict of interest: No Introduction and Objectives: Decompensated cirrhosis (DC) is an important cause of death worldwide, including in Latin America. This study aimed to evaluate in-hospital and 30-day post-discharge mortality in a mult…
View article: Brain reserve in hepatic encephalopathy: Pathways of damage and preventive strategies through lifestyle and therapeutic interventions
Brain reserve in hepatic encephalopathy: Pathways of damage and preventive strategies through lifestyle and therapeutic interventions Open
Brain reserve is an important concept to understand the variability of damage associated with brain-related diseases and includes the adaptation of cognitive processes to preserve brain function. A good cognitive reserve might delay the on…
View article: Pirfenidone use in fibrotic diseases: What do we know so far?
Pirfenidone use in fibrotic diseases: What do we know so far? Open
Background Pirfenidone has demonstrated significant anti‐inflammatory and antifibrotic effects in both animal models and some clinical trials. Its potential for antifibrotic activity positions it as a promising candidate for the treatment …
View article: P-6 PREVALENCE AND CLINICAL CHARACTERISTICS OF LEAN NON-ALCOHOLIC FATTY LIVER DISEASE IN MÉXICO
P-6 PREVALENCE AND CLINICAL CHARACTERISTICS OF LEAN NON-ALCOHOLIC FATTY LIVER DISEASE IN MÉXICO Open
Non-alcoholic fatty liver disease (NAFLD) is one of the main etiologies of chronic liver disease and is mainly observed in people with obesity and type 2 diabetes mellitus; however it is estimated that 7%-20% of individuals with NAFLD have…
View article: Doppler umbilical artery and middle cerebral artery flowmetry in foetuses affected by foetal growth restriction (FGR) treated with transdermal nitroglycerin
Doppler umbilical artery and middle cerebral artery flowmetry in foetuses affected by foetal growth restriction (FGR) treated with transdermal nitroglycerin Open
Objective.The objective was the evaluation of Doppler velocimetry of the umbilical artery and middle cerebral artery in foetuses affected by late foetal growth restriction (FGR) treated with transdermal nitroglycerin (Nitroderm ® ).
View article: Rifaximin Alfa and Liver Diseases: More Than a Treatment for Encephalopathy, a Disease Modifier
Rifaximin Alfa and Liver Diseases: More Than a Treatment for Encephalopathy, a Disease Modifier Open
RFX, a rifamycin-based antibacterial agent obtained by the culture of the actinomycete Streptomyces mediterranei, has a broad antibacterial spectrum covering gram- positive, gram-negative, aerobic, and anaerobic bacteria. RFX is an antibio…
View article: Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America
Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America Open
Three hundred ninety-five patients (31.0%) had ACLF of any grade at enrollment. Patients with ACLF had a higher median percentage of Native American genetic ancestry and lower median percentage of European ancestry than patients without AC…
View article: Global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium
Global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium Open
View article: Silymarin in the management of liver enzyme activity in steatohepatitis: a case report
Silymarin in the management of liver enzyme activity in steatohepatitis: a case report Open
Metabolic-associated fatty liver disease (MAFLD) is the main condition of altered liver enzymes worldwide. With a constant increase in liver hospitalizations, MAFLD is the second cause of cirrhosis and soon will be the first cause of liver…
View article: Visión actual sobre el diagnóstico y los cuidados integrales en la encefalopatía hepática
Visión actual sobre el diagnóstico y los cuidados integrales en la encefalopatía hepática Open
Resumen: La primera guía clínica sobre la encefalopatía hepática se publicó en el año 2009, a casi 14 años de esta primera publicación, numerosos avances en el campo del diagnóstico, tratamiento y cuidados en condiciones especiales, han oc…
View article: Current vision on diagnosis and comprehensive care in hepatic encephalopathy
Current vision on diagnosis and comprehensive care in hepatic encephalopathy Open
The first clinical guidelines on hepatic encephalopathy were published in 2009. Almost 14 years since that first publication, numerous advances in the field of diagnosis, treatment, and special condition care have been made. Therefore, as …
View article: OP-4 IMPLEMENTATION OF A RE-LINKAGE TO CARE STRATEGY IN PATIENTS WITH CHRONIC HEPATITIS C WHO WERE LOST TO FOLLOW-UP IN LATIN AMERICA
OP-4 IMPLEMENTATION OF A RE-LINKAGE TO CARE STRATEGY IN PATIENTS WITH CHRONIC HEPATITIS C WHO WERE LOST TO FOLLOW-UP IN LATIN AMERICA Open
Aproximadamente 1 de cada 4 pacientes con VHC crónico que eran LTFU eran candidatos para recibir tratamiento. Esta estrategia tiene el potencial de ser efectiva y accesible y tiene un impacto significativo en la cascada de atención del VHC.
View article: Liver transplantation is beneficial regardless of cirrhosis stage or acute-on-chronic liver failure grade: A single-center experience
Liver transplantation is beneficial regardless of cirrhosis stage or acute-on-chronic liver failure grade: A single-center experience Open
Patients may benefit from liver transplantation regardless of the cirrhosis stage. ACLF patients have a longer hospital stay and frequency of infectious complications; however, excellent, and comparable 1 and 6-year survival rates support …
View article: Position statement on the use of albumin in liver cirrhosis
Position statement on the use of albumin in liver cirrhosis Open
Cirrhosis is characterised by a prolonged asymptomatic period in which the inflammation persists, increasing as the disease progresses. Characteristic of this is the increase in pro-inflammatory cytokines and pro-oxidant molecules which ar…
View article: Editorial: Liver Fibrosis and MAFLD: From Molecular Aspects to Novel Pharmacological Strategies
Editorial: Liver Fibrosis and MAFLD: From Molecular Aspects to Novel Pharmacological Strategies Open
EDITORIAL article Front. Med., 28 April 2022Sec. Gastroenterology https://doi.org/10.3389/fmed.2022.892495
View article: Epidemiological and Genetic Aspects of NAFLD and NASH in Mexico
Epidemiological and Genetic Aspects of NAFLD and NASH in Mexico Open
Content available: Author Interview and Audio Recording.
View article: Economic evaluation of long-term albumin use in cirrhosis patients from the Mexican healthcare system perspective
Economic evaluation of long-term albumin use in cirrhosis patients from the Mexican healthcare system perspective Open
Based on the ANSWER trial results, our study suggests that LTA may result in improved clinical outcomes and reduced costs for the IMSS when administered to cirrhosis patients with uncomplicated ascites.
View article: Prevalence of Metabolic-associated Fatty Liver Disease in Mexico and Development of a Screening Tool: The MAFLD-S Score
Prevalence of Metabolic-associated Fatty Liver Disease in Mexico and Development of a Screening Tool: The MAFLD-S Score Open
View article: The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study
The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study Open
INTRODUCTION: Several scoring systems predict mortality in alcohol-associated hepatitis (AH), including the Maddrey discriminant function (mDF) and model for end-stage liver disease (MELD) score developed in the United States, Glasgow alco…
View article: P-13 COMPARISON OFF DIFFERENT PROGNOSTIC SCORES FOR PATIENTS WITH CIRRHOSIS HOSPITALIZED WITH SARS – COV 2 INFECTION
P-13 COMPARISON OFF DIFFERENT PROGNOSTIC SCORES FOR PATIENTS WITH CIRRHOSIS HOSPITALIZED WITH SARS – COV 2 INFECTION Open
Introduction and Objectives: Viral infections have been described to increase the risk of decompensation in patients with cirrhosis. We aimed to determine the impact of SARS-CoV-2 infection on clinical outcome of hospitalized patients with…
View article: Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: A worldwide study
Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: A worldwide study Open
View article: Comparison of different prognostic scores for patients with cirrhosis hospitalized with SARS-CoV-2 infection
Comparison of different prognostic scores for patients with cirrhosis hospitalized with SARS-CoV-2 infection Open
SARS-CoV-2 infection is associated with elevated mortality in patients with cirrhosis. CLIF-C had better performance in predicting mortality than NACSELD, CTP and MELD-Na in patients with cirrhosis and SARS-CoV-2 infection. Clinicaltrials.…
View article: Effect of non-alcoholic beer, diet and exercise on endothelial function, nutrition and quality of life in patients with cirrhosis
Effect of non-alcoholic beer, diet and exercise on endothelial function, nutrition and quality of life in patients with cirrhosis Open
The intervention consisting of non-alcoholic beer, diet and exercise seems to be safe and well tolerated in patients with cirrhosis, and shows improvement in nutritional status, endothelial function, and quality of life. These results need…
View article: Renal and brain failure predict mortality of patients with acute-on-chronic liver failure admitted to the intensive care unit
Renal and brain failure predict mortality of patients with acute-on-chronic liver failure admitted to the intensive care unit Open
ACLF is a frequent syndrome among chronic liver disease patients. Brain and renal failure are significantly associated with higher mortality and are independent predictors of 28 and 90-day mortality.
View article: Benefits of prolonged-release pirfenidone plus standard of care treatment in patients with advanced liver fibrosis: PROMETEO study
Benefits of prolonged-release pirfenidone plus standard of care treatment in patients with advanced liver fibrosis: PROMETEO study Open
Background and aims Pirfenidone (PFD), an oral antifibrotic drug, has been authorized by the EMA and FDA for treatment of idiopathic pulmonary fibrosis. Few studies have addressed its use in advanced liver fibrosis (ALF). We evaluated a pr…