Alec A Jones
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View article: Automation of protein crystallization scaleup via Opentrons-2 liquid handling
Automation of protein crystallization scaleup via Opentrons-2 liquid handling Open
In this study we present an approach for optimizing protein crystallization trials at the multi-microliter scale utilizing the Opentrons-2 liquid handling robot. Our research demonstrates the robot's capability to automate 24-well sitting …
View article: Deposition of metal–organic frameworks within a porous protein crystal superstructure
Deposition of metal–organic frameworks within a porous protein crystal superstructure Open
A cartoon, theoretical representation of a highly porous protein crystal that has been subjected to MOF growth conditions, highlighting the union of both the proteinaceous components and MOF components of the hybrid material.
View article: Porous protein crystals: synthesis and applications
Porous protein crystals: synthesis and applications Open
Emerging applications of large pore protein crystals (LPCs), with a focus on catalysis, in vivo delivery of therapeutic biomolecules, and scaffold-assisted structure determination (SASD), are reviewed in detail.
View article: Exposure to valproic acid (VPA) reproduces hdac1 loss of function phenotypes in zebrafish
Exposure to valproic acid (VPA) reproduces hdac1 loss of function phenotypes in zebrafish Open
Histone deacetylases are enzymes that remove acetyl groups from histone tails and are understood to act as repressors of transcriptional activity. Hdac1 has been previously shown to function in eye, pectoral fin, heart, liver, and pharynge…
View article: Mosquito tagging using DNA-barcoded nanoporous protein microcrystals
Mosquito tagging using DNA-barcoded nanoporous protein microcrystals Open
Conventional mosquito marking technology for mark–release–recapture (MRR) is quite limited in terms of information capacity and efficacy. To overcome both challenges, we have engineered, lab-tested, and field-evaluated a new class of marke…