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View article: Early life adversity shapes social subordination and cell type–specific transcriptomic patterning in the ventral hippocampus
Early life adversity shapes social subordination and cell type–specific transcriptomic patterning in the ventral hippocampus Open
Adverse events in early life can modulate the response to additional stressors later in life and increase the risk of developing psychiatric disorders. The underlying molecular mechanisms responsible for these effects remain unclear. Here,…
View article: The role of TET proteins in stress-induced neuroepigenetic and behavioural adaptations
The role of TET proteins in stress-induced neuroepigenetic and behavioural adaptations Open
Over the past decade, critical, non-redundant roles of the ten-eleven translocation (TET) family of dioxygenase enzymes have been identified in the brain during developmental and postnatal stages. Specifically, TET-mediated active demethyl…
View article: Adolescent chronic intermittent toluene inhalation dynamically regulates the transcriptome and neuronal methylome within the rat medial prefrontal cortex
Adolescent chronic intermittent toluene inhalation dynamically regulates the transcriptome and neuronal methylome within the rat medial prefrontal cortex Open
Inhalants containing the volatile solvent toluene are misused to induce euphoria or intoxication. Inhalant abuse is most common during adolescence and can result in cognitive impairments during an important maturational period. Despite evi…
View article: Adenosine-to-Inosine RNA Editing Within Corticolimbic Brain Regions Is Regulated in Response to Chronic Social Defeat Stress in Mice
Adenosine-to-Inosine RNA Editing Within Corticolimbic Brain Regions Is Regulated in Response to Chronic Social Defeat Stress in Mice Open
Adenosine-to-inosine (A-to-I) RNA editing is a co-/posttranscriptional modification of double-stranded RNA, catalyzed by the adenosine deaminase acting on RNA (ADAR) family of enzymes, which results in recognition of inosine as guanosine b…
View article: Epigenetic mechanisms involved in the effects of stress exposure: focus on 5-hydroxymethylcytosine: Table 1:
Epigenetic mechanisms involved in the effects of stress exposure: focus on 5-hydroxymethylcytosine: Table 1: Open
5-hydroxymethylcytosine (5hmC) is a recently re-discovered transient intermediate in the active demethylation pathway that also appears to play an independent role in modulating gene function. Epigenetic marks, particularly 5-methylcytosin…
View article: ISDN2014_0438: Chronic intermittent toluene inhalation during adolescence in rats results in circuit level dysfunction in the absence of overt neuropathology
ISDN2014_0438: Chronic intermittent toluene inhalation during adolescence in rats results in circuit level dysfunction in the absence of overt neuropathology Open
The abuse of inhaled vapours containing toluene is a growing problem, especially for adolescent populations where brain maturation processes are still occurring. Human studies report cognitive deficits following adolescent inhalant abuse, …
View article: Chronic intermittent toluene inhalation in adolescent rats results in metabolic dysfunction with altered glucose homeostasis
Chronic intermittent toluene inhalation in adolescent rats results in metabolic dysfunction with altered glucose homeostasis Open
Background and Purpose Abuse of toluene‐containing inhalants is an increasing public health problem, especially among adolescents. Abuse during adolescence is associated with emaciation, while industrial exposure leads to altered glycaemic…