Alec Kittredge
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View article: Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment
Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment Open
View article: GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel
GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel Open
Bestrophin-1 (Best1) is an anion channel genetically linked to vision-threatening retinal degenerative channelopathies. Here, we identify interactions between Best1 and both isoforms of glutamic acid decarboxylases (GAD65 and GAD67), eluci…
View article: Bestrophin-2 and glutamine synthetase form a complex for glutamate release
Bestrophin-2 and glutamine synthetase form a complex for glutamate release Open
View article: Cryo-EM analysis of gating dynamics in mammalian bestrophins
Cryo-EM analysis of gating dynamics in mammalian bestrophins Open
View article: Structures and gating mechanisms of human bestrophin anion channels
Structures and gating mechanisms of human bestrophin anion channels Open
View article: Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations
Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations Open
Genetic mutation of the human BEST1 gene, which encodes a Ca 2+ -activated Cl - channel (BEST1) predominantly expressed in retinal pigment epithelium (RPE), causes a spectrum of retinal degenerative disorders commonly known as bestrophinop…
View article: Author response: Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations
Author response: Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Genetic mutation of the human BEST1 gene, …
View article: Structure and Function of the Bestrophin family of calcium-activated chloride channels
Structure and Function of the Bestrophin family of calcium-activated chloride channels Open
Bestrophins are a family of calcium-activated chloride channels (CaCCs) with relevance to human physiology and a myriad of eye diseases termed "bestrophinopathies". Since the identification of bestrophins as CaCCs nearly two decades ago, e…
View article: Evaluating BEST1 mutations in pluripotent stem cell-derived retinal pigment epithelial cells
Evaluating BEST1 mutations in pluripotent stem cell-derived retinal pigment epithelial cells Open
View article: Structural and functional characterization of the bestrophin-2 anion channel
Structural and functional characterization of the bestrophin-2 anion channel Open
View article: Dual Ca2+-Dependent Gates in Human Bestrophin1 Underlie Disease-Causing Mechanisms of Gain-Of-Function Mutations
Dual Ca2+-Dependent Gates in Human Bestrophin1 Underlie Disease-Causing Mechanisms of Gain-Of-Function Mutations Open
View article: Investigation and Restoration of BEST1 Activity in Patient-derived RPEs with Dominant Mutations
Investigation and Restoration of BEST1 Activity in Patient-derived RPEs with Dominant Mutations Open
View article: Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations
Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations Open
View article: Dissecting the Structure and Function of Bestrophin Channels
Dissecting the Structure and Function of Bestrophin Channels Open
View article: Expression and Purification of Mammalian Bestrophin Ion Channels
Expression and Purification of Mammalian Bestrophin Ion Channels Open
The human genome encodes four bestrophin paralogs, namely BEST1, BEST2, BEST3, and BEST4. BEST1, encoded by the BEST1 gene, is a Ca2+-activated Cl- channel (CaCC) predominantly expressed in retinal pigment epithelium …
View article: ATP activates bestrophin ion channels through direct interaction
ATP activates bestrophin ion channels through direct interaction Open
View article: Dissecting the structure and function of bestrophin channels
Dissecting the structure and function of bestrophin channels Open
View article: Patient-Specific Mutations Impair Bestrophin1's Essential Role in Mediating Ca2+-Dependent CL- Currents in Human RPE
Patient-Specific Mutations Impair Bestrophin1's Essential Role in Mediating Ca2+-Dependent CL- Currents in Human RPE Open
View article: Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE
Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE Open
Mutations in the human BEST1 gene lead to retinal degenerative diseases displaying progressive vision loss and even blindness. BESTROPHIN1, encoded by BEST1, is predominantly expressed in retinal pigment epithelium (RPE), but its physiolog…
View article: Author response: Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE
Author response: Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mutations in the human BEST1 …