Explanipedia

Phrenic Long-Term Facilitation Following Acute Intermittent Hypercapnic-Hypoxia in Rats Open

Alec L. E. Butenas, Gordon S. Mitchell · 2025

Phrenic long-term facilitation (pLTF) is a form of respiratory motor plasticity, expressed as a lasting increase in phrenic nerve activity following acute intermittent hypoxia (AIH). Whereas AIH also elicits ventilatory LTF (vLTF) in unane…

The impact of topical capsaicin application on the muscle metaboreflex and microvascular responsiveness Open

Nancy J. Carpenter, Aaron E. Wahl, Alec L. E. Butenas, Sherwin G. Toribio, Jacob T. Caldwell · 2025

Topical capsaicin reduces metaboreflex responses during post‐exercise circulatory arrest (PECA) in males, but its effects in females and on microvascular responsiveness in either sex remain unclear. This study hypothesized that capsaicin w…

Sex differences in the purinergic 2 receptor-mediated blood pressure response to treadmill exercise in rats with simulated peripheral artery disease Open

Alec L. E. Butenas, Joseph Flax, Raimi Carroll, Chairat Chuwonganant, Ashley Baranczuk , et al. · 2024

Here, we demonstrate that purinergic 2 (P2) receptors contribute significantly to the blood pressure response to treadmill exercise in male rats both with and without simulated PAD induced by femoral artery ligation. We found no role for P…

Impaired microvascular reactivity in patients treated with 5-fluorouracil chemotherapy regimens: Potential role of endothelial dysfunction Open

Stephen T. Hammond, Dryden R. Baumfalk, Shannon K. Parr, Alec L. E. Butenas, Britton Scheuermann , et al. · 2023

Sex-dependent attenuating effects of capsaicin administration on the mechanoreflex in healthy rats Open

Alec L. E. Butenas, Rie Ishizawa, Korynne S. Rollins, Masaki Mizuno, Steven W. Copp · 2023

Recent evidence in isolated sensory neurons indicates that capsaicin-induced stimulation of TRPV1 attenuates mechanosensitivity. Here we demonstrate for the first time that capsaicin exposure/administration reduces the reflex pressor and r…

Effects of comorbid type II diabetes mellitus and heart failure on rat hindlimb and respiratory muscle blood flow during treadmill exercise Open

Alec L. E. Butenas, Steven W. Copp, K. Sue Hageman, David C. Poole, Timothy I. Musch · 2023

Herein, we demonstrate that rats comorbid with heart failure with reduced ejection fraction (HF-rEF) and type II diabetes mellitus (T2DM) have a higher hindlimb and respiratory muscle blood flow during submaximal treadmill running (20 m·mi…

Bradykinin 2 receptors contribute to the exaggerated exercise pressor reflex in a rat model of simulated peripheral artery disease Open

Alec L. E. Butenas, Korynne S. Rollins, Auni C. Williams, Steven W. Copp · 2022

We investigated the role played by bradykinin 2 (B2) receptors in the exaggerated exercise pressor reflex in rats with a femoral artery ligated for 72 h to induce simulated peripheral artery disease (PAD). We hypothesized that in decerebra…

Sensory neuron inositol 1,4,5-trisphosphate receptors contribute to chronic mechanoreflex sensitization in rats with simulated peripheral artery disease Open

Korynne S. Rollins, Alec L. E. Butenas, Auni C. Williams, Steven W. Copp · 2021

The mechanoreflex is exaggerated in patients with peripheral artery disease (PAD) and in a rat model of simulated PAD in which a femoral artery is chronically (∼72 h) ligated. We found recently that, in rats with a ligated femoral artery, …

Thromboxane A 2 receptors contribute to the exaggerated exercise pressor reflex in male rats with heart failure Open

Alec L. E. Butenas, Korynne S. Rollins, Auni C. Williams, Shannon K. Parr, Stephen T. Hammond , et al. · 2021

Mechanical and metabolic signals associated with skeletal muscle contraction stimulate the sensory endings of thin fiber muscle afferents and produce reflex increases in sympathetic nerve activity and blood pressure during exercise (i.e., …

Exaggerated sympathetic and cardiovascular responses to dynamic mechanoreflex activation in rats with heart failure: Role of endoperoxide 4 and thromboxane A2 receptors Open

Alec L. E. Butenas, Korynne S. Rollins, Auni C. Williams, Shannon K. Parr, Stephen T. Hammond , et al. · 2021

Angiotensin converting enzyme inhibition improves cerebrovascular control during exercise in male rats with heart failure Open

Alec L. E. Butenas, Trenton D. Colburn, Dryden R. Baumfalk, Carl J. Ade, K. Sue Hageman , et al. · 2021

Effects of high-intensity training on prostate cancer-induced cardiac atrophy. Open

Dryden R. Baumfalk, Alexander B Opoku-Acheampong, Jacob T. Caldwell, Alec L. E. Butenas, Andrew G. Horn , et al. · 2021

This study suggests that high-intensity exercise can improve LV function and increase LV mass concurrent with prostate cancer development, versus sedentary counterparts. Given cardiac dysfunction often manifests with conventional anti-canc…

No effect of endoperoxide 4 or thromboxane A2 receptor blockade on static mechanoreflex activation in rats with heart failure Open

Alec L. E. Butenas, Korynne S. Rollins, Jacob E. Matney, Auni C. Williams, Talyn E. Kleweno , et al. · 2020

New Findings What is the central question of this study? Do endoperoxide 4 and thromboxane A 2 receptors, which are receptors for cyclooxygenase products of arachidonic metabolism, on thin fibre muscle afferents play a role in the chronic …

Type II diabetes accentuates diaphragm blood flow increases during submaximal exercise in the rat Open

Alec L. E. Butenas, Joshua R. Smith, Steven W. Copp, K. Sue Hageman, David C. Poole , et al. · 2020

Thromboxane A2 receptors mediate chronic mechanoreflex sensitization in a rat model of simulated peripheral artery disease Open

Korynne S. Rollins, Alec L. E. Butenas, Kennedy P. Felice, Jacob E. Matney, Auni C. Williams , et al. · 2020

We demonstrate that thromboxane A 2 receptors, but not endoperoxide 4 receptors, on the sensory endings of thin fiber muscle afferents contribute to the chronic sensitization of the muscle mechanoreflex in rats with a ligated femoral arter…

Investigation of the mechanisms of cyclooxygenase-mediated mechanoreflex sensitization in a rat model of simulated peripheral artery disease Open

Alec L. E. Butenas, Tyler D. Hopkins, Korynne S. Rollins, Kennedy P. Felice, Steven W. Copp · 2019

Mechanical and metabolic stimuli within contracting skeletal muscles reflexly increase sympathetic nervous system activity and blood pressure. That reflex, termed the exercise pressor reflex, is exaggerated in patients with peripheral arte…

Cyclooxygenase inhibition does not impact the pressor response during static or dynamic mechanoreflex activation in healthy decerebrate rats Open

Korynne S. Rollins, Tyler D. Hopkins, Alec L. E. Butenas, Kennedy P. Felice, Carl J. Ade , et al. · 2019

Passive limb movement and limb muscle stretch in humans and animals are common experimental strategies used to investigate activation of the muscle mechanoreflex independent of contraction-induced metabolite production. Cyclooxygenase (COX…

GsMTx4 reduces the reflex pressor response during dynamic hindlimb skeletal muscle stretch in decerebrate rats Open

Bailey C. Sanderson, Korynne S. Rollins, Tyler D. Hopkins, Alec L. E. Butenas, Kennedy P. Felice , et al. · 2019

Mechanical signals within contracting skeletal muscles contribute to the generation of the exercise pressor reflex; an important autonomic and cardiovascular control mechanism. In decerebrate rats, the mechanically activated channel inhibi…

Chronic femoral artery ligation exaggerates the pressor and sympathetic nerve responses during dynamic skeletal muscle stretch in decerebrate rats Open

E Kempf, Korynne S. Rollins, Tyler D. Hopkins, Alec L. E. Butenas, Joseph M. Santin , et al. · 2017

Mechanical and metabolic signals arising during skeletal muscle contraction reflexly increase sympathetic nerve activity and blood pressure (i.e., the exercise pressor reflex). In a rat model of simulated peripheral artery disease in which…

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